diff --git a/src/main/webapp/app/components/SimpleTable.tsx b/src/main/webapp/app/components/SimpleTable.tsx
index a419cbe56..dd5afd49f 100644
--- a/src/main/webapp/app/components/SimpleTable.tsx
+++ b/src/main/webapp/app/components/SimpleTable.tsx
@@ -2,7 +2,10 @@ import * as React from 'react';
 import { Table } from 'react-bootstrap';
 
 export type ElementType = JSX.Element | string;
-export type SimpleTableCell = { key: string; content: ElementType };
+export type SimpleTableCell = {
+  key: string;
+  content: ElementType | ElementType[];
+};
 export type SimpleTableRow = { key: string; content: SimpleTableCell[] };
 export type SimpleTableRows = SimpleTableRow[];
 export type SimpleTableColumn = {
@@ -21,8 +24,8 @@ export type SimpleTableProps = {
 export const SimpleTable = (props: SimpleTableProps) => {
   const getRow = (row: SimpleTableRow) => {
     return row.content
-      ? row.content.map(cell => {
-          return <td key={cell.key}>{cell.content}</td>;
+      ? row.content.map(({ key, content }) => {
+          return <td key={key}>{content}</td>;
         })
       : null;
   };
@@ -44,9 +47,41 @@ export const SimpleTable = (props: SimpleTableProps) => {
           </thead>
         )}
         <tbody className={props.tbodyClassName}>
-          {props.rows.map(row => (
-            <tr key={row.key}>{getRow(row)}</tr>
-          ))}
+          {props.rows.flatMap(({ key, content }) => {
+            let maxContentSize = 1;
+            for (const cur of content) {
+              maxContentSize = Array.isArray(cur.content)
+                ? Math.max(cur.content.length, maxContentSize)
+                : maxContentSize;
+            }
+            const elements: JSX.Element[] = [];
+            for (let i = 0; i < maxContentSize; i++) {
+              const element = (
+                <tr key={`${key}_${i}`}>
+                  {content.map(({ content: innerContent, key: innerKey }) => {
+                    if (Array.isArray(innerContent)) {
+                      return <td key={innerKey}>{innerContent[i]}</td>;
+                    } else if (i === 0) {
+                      return (
+                        <td
+                          key={innerKey}
+                          rowSpan={
+                            maxContentSize > 1 ? maxContentSize : undefined
+                          }
+                        >
+                          {innerContent}
+                        </td>
+                      );
+                    } else {
+                      return <></>;
+                    }
+                  })}
+                </tr>
+              );
+              elements.push(element);
+            }
+            return elements;
+          })}
         </tbody>
       </Table>
     </div>
diff --git a/src/main/webapp/app/config/constants.tsx b/src/main/webapp/app/config/constants.tsx
index 9bf39edae..24e64d27e 100644
--- a/src/main/webapp/app/config/constants.tsx
+++ b/src/main/webapp/app/config/constants.tsx
@@ -821,6 +821,7 @@ export type DataRelease = {
 };
 
 export const DATA_RELEASES: DataRelease[] = [
+  { date: '10242024', version: 'v4.22' },
   { date: '09252024', version: 'v4.21' },
   { date: '08152024', version: 'v4.20' },
   { date: '07042024', version: 'v4.19' },
@@ -948,6 +949,7 @@ export const DEFAULT_FEEDBACK_ANNOTATION: Feedback = {
   type: FeedbackType.ANNOTATION,
 };
 
+export type FdaSubmissionType = 'PMA' | 'PMN' | 'HDE' | 'DEN';
 export const FDA_SUBMISSION_URL_SUFFIX = {
   PMA: 'cfpma/pma.cfm',
   PMN: 'cfpmn/pmn.cfm',
diff --git a/src/main/webapp/app/pages/companionDiagnosticDevicesPage/companionDiagnosticDevicePage.tsx b/src/main/webapp/app/pages/companionDiagnosticDevicesPage/companionDiagnosticDevicePage.tsx
index aad91d26a..d595bc2ad 100644
--- a/src/main/webapp/app/pages/companionDiagnosticDevicesPage/companionDiagnosticDevicePage.tsx
+++ b/src/main/webapp/app/pages/companionDiagnosticDevicesPage/companionDiagnosticDevicePage.tsx
@@ -87,6 +87,52 @@ interface ICancerType {
   tumorForm: 'SOLID' | 'LIQUID' | 'MIXED';
 }
 
+interface IRule {
+  id: number;
+  entity: string;
+  rule: string;
+  name: string | null;
+  association: IAssociation | null;
+}
+
+interface IAssociation {
+  id: number;
+  name: string | null;
+  rules: IRule[] | null;
+  alterations: IAlteration[] | null;
+  cancerTypes: ICancerType[] | null;
+  drugs: IDrug[] | null;
+  fdaSubmissions: IFdaSubmission[] | null;
+}
+
+interface IDrug {
+  id: number;
+  uuid: string;
+  name: string;
+  associations: IAssociation[] | null;
+}
+
+interface IAlteration {
+  id: number;
+  name: string;
+  alteration: string;
+  proteinChange: string;
+  start: number | null;
+  end: number | null;
+  refResidues: string | null;
+  variantResidues: string | null;
+  genes: IGene[] | null;
+  associations: IAssociation[] | null;
+}
+
+interface IGene {
+  id: number;
+  entrezGeneId: number;
+  hugoSymbol: string;
+  hgncId: string | null;
+  alterations: IAlteration[] | null;
+}
+
 type SelectOption = {
   value: string;
   label: string;
@@ -99,6 +145,27 @@ const referenceColumnInfo = (
   </div>
 );
 
+const getDrugName = (drugs: IDrug[], rules: IRule[]) => {
+  // Create a map of drug ids to drug names for quick lookup
+  const drugMap = new Map();
+  drugs.forEach((drug: any) => {
+    drugMap.set(drug.id, drug.name);
+  });
+
+  const drugRule = rules.filter((rule: IRule) => rule.entity === 'DRUG')[0];
+
+  if (!drugRule) {
+    return drugs[0].name;
+  }
+  return drugRule.rule
+    .split(/([+,])/)
+    .map((part: any) => {
+      const id = parseInt(part, 10);
+      return isNaN(id) ? part : drugMap.get(id) || part;
+    })
+    .join('');
+};
+
 const parseCDx = () => {
   const parsedCompanionDiagnosticDevices: ICompanionDiagnosticDevice[] = [];
   for (const cdx of companionDiagnosticDevices) {
@@ -131,18 +198,8 @@ const parseCDx = () => {
         ).map((gene: any) => ({
           gene,
           alterations: uniq(assoc.alterations.map((a: any) => a.name)).sort(),
-          drugs: assoc.treatments
-            .map((treatment: any) =>
-              treatment.drugs.map((drug: any) => drug.name).join(' + ')
-            )
-            .join(', '),
-          cancerTypes: assoc.associationCancerTypes.reduce(
-            (ctAcc: any[], act: any) => {
-              ctAcc.push(act.cancerType);
-              return ctAcc;
-            },
-            []
-          ),
+          drugs: getDrugName(assoc.drugs, assoc.rules),
+          cancerTypes: assoc.cancerTypes,
           fdaSubmissions: assoc.fdaSubmissions,
         }));
       })
diff --git a/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx b/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
index 31a76afd1..ad17819b2 100644
--- a/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
+++ b/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
@@ -117,7 +117,7 @@ export const ChangedAnnotationListItem = (props: {
     case AnnotationColumnHeaderType.UPDATED_SAME_LEVEL_DRUG:
       annotationColumnHeader = CHANGED_ANNOTATION_UPDATED_DRUG_SAME_HIGHEST_LEVEL_COLUMNS;
       defaultTitle =
-        "Addition of drug(s) associated with a tumor type-specific leveled alteration(s) currently in OncoKB™ (without changing the alteration's highest level of evidence)";
+        "Updated therapeutic implications - Addition of drug(s) associated with a tumor type-specific leveled alteration(s) currently in OncoKB™ (without changing the alteration's highest level of evidence)";
       useOneLineRowClass = true;
       break;
     case AnnotationColumnHeaderType.LEVEL:
diff --git a/src/main/webapp/app/pages/newsPage/NewsPage.tsx b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
index c172f5ba5..3ec5c1f8b 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPage.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
@@ -87,6 +87,7 @@ export default class NewsPage extends React.Component<{
           <CitationText />
         </div>
         <div className="mt-2">
+          <NewsList date={'10242024'} />
           <NewsList date={'09252024'} />
           <NewsList date={'08152024'} />
           <NewsList date={'07042024'} />
diff --git a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
index 4465b1546..085dd166f 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
@@ -46,7 +46,7 @@ import { AnnotationColumnHeaderType } from './ChangedAnnotationListItem';
 import { linkableMutationName, convertGeneInputToLinks } from './Util';
 
 export type ChangedAnnotation = {
-  content: ElementType[][];
+  content: (ElementType | ElementType[])[][];
   title?: string;
   columnHeaderType?: AnnotationColumnHeaderType;
   headers?: { name: string }[];
@@ -300,6 +300,270 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
 // https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
 
 export const NEWS_BY_DATE: { [date: string]: NewsData } = {
+  '10242024': {
+    priorityNews: [
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.CDX}>
+          FDA Cleared or Approved Companion Diagnostic Devices
+        </Link>{' '}
+        (CDx) page
+      </span>,
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.ONCOLOGY_TX}>FDA-Approved Oncology Therapies</Link>{' '}
+        page
+      </span>,
+    ],
+    changedAnnotations: [
+      {
+        columnHeaderType: AnnotationColumnHeaderType.NEW_ALTERATION_WITH_LEVEL,
+        content: [
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'G2032R')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+
+            ['Taletrectinib', 'Crizotinib, Lorlatinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="38822758, 31399568" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink
+                  wrapText
+                  pmids="33685866, 29333528, 23724914, 36135089, 36135089, 32918045"
+                />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'L2086F')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+            ['Cabozantinib', 'Lorlatinib, Repotrectinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="33685866, 37291202, 39117775, 39091594" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="37291202, 33685866, 39091594" />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            '3A',
+            'SMARCA4',
+            'Oncogenic Mutations',
+            'Non-Small Cell Lung Cancer, Esophageal Adenocarcinoma',
+            'PRT3789',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Guo, R. et al., Abstract# 603O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02189-6/fulltext"
+              />
+              <AbstractLink
+                abstract="Hulse, M. et al., Abstract# 3263, AACR 2022"
+                link="https://aacrjournals.org/cancerres/article/82/12_Supplement/3263/703325/Abstract-3263-Preclinical-characterization-of"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        useOneLineRowClass: false,
+        title:
+          'Updated therapeutic implications - Promotion of tumor type-specific level of evidence for an alteration(s)',
+        headers: CHANGED_ANNOTATION_LEVEL_WITH_EVIDENCE_COLUMNS,
+        content: [
+          [
+            'PIK3CA',
+            <>
+              <AlterationPageLink
+                hugoSymbol="PIK3CA"
+                alteration="Oncogenic Mutations"
+              />{' '}
+              <span>
+                (excluding R88Q, N345K, C420R, E542K, E545A/D/G/K/Q,
+                Q546E/K/R/P, M1043V/I, H1047Y/R/L, G1049R which are already
+                Level 1)
+              </span>
+            </>,
+            'Breast Cancer',
+            <div>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_CURRENTLY_IN_ONCOKB}:
+              </div>
+              <div>
+                Alpelisib + Fulvestrant, Capivasertib + Fulvestrant (Level 2)
+              </div>
+              <br></br>
+              <div>Inavolisib + Palbociclib + Fulvestrant (Level 3A)</div>
+              <br></br>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_PROMOTED_IN_ONCOKB}:
+              </div>
+              <div>Inavolisib + Palbociclib + Fulvestrant (Level 1)</div>
+            </div>,
+            '2',
+            '1',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib + Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        columnHeaderType: AnnotationColumnHeaderType.UPDATED_SAME_LEVEL_DRUG,
+        content: [
+          [
+            '1',
+            'EGFR',
+            <>
+              <AlterationPageLink
+                hugoSymbol="EGFR"
+                alteration={'Exon 19 in-frame deletions'}
+              />
+              , <AlterationPageLink hugoSymbol="EGFR" alteration={'L858R'} />
+            </>,
+            'Non-Small Cell Lung Cancer',
+            <>
+              <div>
+                Afatinib, Dacomitinib, Erlotinib, Erlotinib + Ramucirumab,
+                Gefitinib, Osimertinib, Osimertinib + Chemotherapy, Amivantamab
+                + Lazertinib (Level 1)
+              </div>
+              <br></br>
+              <div>Amivantamab + Chemotherapy (Level 2)</div>
+              <br></br>
+              <div>Patritumab Deruxtecan (Level 3A)</div>
+            </>,
+
+            'Amivantamab + Chemotherapy (Level 1)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Amivantamab with Chemotherapy"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-amivantamab-vmjw-carboplatin-and-pemetrexed-non-small-cell-lung-cancer-egfr-exon-19"
+              />
+              <PMIDLink pmids="37879444" />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'PIK3CA',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('PIK3CA', 'R88Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'N345K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'C420R')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E542K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E545A/D/G/K/Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'Q546E/K/R/P')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'M1043V/I')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'H1047Y/R/L')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'G1049R')}
+            </WithSeparator>,
+            'Breast Cancer',
+            <>
+              <div>Capivasertib + Fulvestrant (Level 1)</div>
+              <br></br>
+              <div>
+                Alpelisib + Fulvestrant (Level 1 for PIK3CA C420R, E542K,
+                E545A/D/G/K, H1047Y/R/L, Q546E/R only)
+              </div>
+            </>,
+            'Inavolisib + Palbociclib + Fulvestrant (Level 1; Promoted from Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib with Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ALK',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            'Alectinib, Brigatinib, Certinib, Crizotinib, Lorlatinib (Level 1)',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024 "
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ROS1',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            <>
+              <div>Crizotinib, Entrectinib, Repotrectinib (Level 1)</div>
+              <br></br>
+              <div>Ceritinib, Lorlatinib (Level 2)</div>
+            </>,
+            'Taletrectinib (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="38822758, 36877099, 31399568" />
+            </WithSeparator>,
+          ],
+          [
+            '2',
+            'ALK',
+            'G1202R',
+            'Non-Small Cell Lung Cancer',
+            'Lorlatinib (Level 2)',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '3A',
+            'KRAS',
+            'G12D',
+            'Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma',
+            'RMC-6236 (Level 3A)',
+            'ASP3082 (Level 3A; Promoted from Level 4)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Park, W. et al., Abstract# 608O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02194-X/fulltext"
+              />
+              <AbstractLink
+                abstract="Nagashima, T. et al., Abstract# 5735, AACR 2023"
+                link="https://aacrjournals.org/cancerres/article/83/7_Supplement/5735/722276"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+    ],
+    newlyAddedGenes: ['ADARB2', 'BUB1B', 'CCN6', 'CDKN1C', 'EGR2'],
+  },
   '09252024': {
     changedAnnotations: [
       {
diff --git a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
index 26572e33e..af1bfbffd 100644
--- a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
+++ b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
@@ -486,7 +486,7 @@ const OncologyTherapiesPage: React.FunctionComponent<{}> = props => {
                 'https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications'
               }
             >
-              Content current as of 8/5/2024
+              Content current as of 10/21/2024
             </Linkout>
           </div>
           <div>
diff --git a/src/main/webapp/app/shared/links/FdaSubmissionLink.tsx b/src/main/webapp/app/shared/links/FdaSubmissionLink.tsx
index 999738f33..15de77762 100644
--- a/src/main/webapp/app/shared/links/FdaSubmissionLink.tsx
+++ b/src/main/webapp/app/shared/links/FdaSubmissionLink.tsx
@@ -1,6 +1,9 @@
 import React from 'react';
 import { getFdaSubmissionNumber, toAppLocalDateFormat } from '../utils/Utils';
-import { FDA_SUBMISSION_URL_SUFFIX } from 'app/config/constants';
+import {
+  FDA_SUBMISSION_URL_SUFFIX,
+  FdaSubmissionType,
+} from 'app/config/constants';
 import { Linkout } from './Linkout';
 import { IFdaSubmission } from 'app/pages/companionDiagnosticDevicesPage/companionDiagnosticDevicePage';
 
@@ -15,9 +18,10 @@ export const FdaSubmissionLink: React.FunctionComponent<{
     props.fdaSubmission.supplementNumber
   );
   const date = toAppLocalDateFormat(props.fdaSubmission.decisionDate);
+  const type = props.fdaSubmission.type.type.split('_')[1] as FdaSubmissionType;
   const link =
     FDA_SUBMISSION_BASE_URL +
-    FDA_SUBMISSION_URL_SUFFIX[props.fdaSubmission.type.type] +
+    FDA_SUBMISSION_URL_SUFFIX[type] +
     '?id=' +
     submissionNumber.replace('/', '');
   return (
diff --git a/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json b/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
index f053cd053..200eea6c7 100644
--- a/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
+++ b/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
@@ -5,7 +5,7 @@
     "manufacturer": "Abbott Molecular, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:37.809127Z",
+    "lastUpdated": "2024-04-06T01:03:37.565709Z",
     "fdaSubmissions": [
       {
         "id": 1,
@@ -19,29 +19,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 1,
+            "id": 119,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
                 "id": 1,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "entity": "DRUG",
+                "rule": "30",
+                "name": null
+              },
+              {
+                "id": 2,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -50,13 +49,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -64,12 +63,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -78,13 +76,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -92,12 +90,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -106,13 +103,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -120,12 +117,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -134,13 +130,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -148,12 +144,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -162,13 +157,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -176,32 +171,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 1,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 29,
-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -217,29 +220,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 2,
+            "id": 120,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 2,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 411,
-                  "code": "MDS",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Myelodysplastic Syndromes",
-                  "subtype": "Myelodysplastic Syndromes",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 3,
+                "entity": "DRUG",
+                "rule": "30",
+                "name": null
+              },
+              {
+                "id": 4,
+                "entity": "CANCER_TYPE",
+                "rule": "411",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -248,13 +250,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -262,12 +264,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -276,13 +277,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -290,12 +291,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -304,13 +304,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -318,12 +318,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -332,13 +331,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -346,12 +345,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -360,13 +358,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -374,32 +372,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 2,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 29,
-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 411,
+                "code": "MDS",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Myelodysplastic Syndromes",
+                "subtype": "Myelodysplastic Syndromes",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -415,29 +421,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 3,
+            "id": 121,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 3,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 5,
+                "entity": "DRUG",
+                "rule": "32",
+                "name": null
+              },
+              {
+                "id": 6,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -446,13 +451,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -460,12 +465,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -474,13 +478,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -488,12 +492,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -502,13 +505,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -516,12 +519,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -530,13 +532,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -544,12 +546,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -558,13 +559,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -572,32 +573,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 3,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 31,
-                    "uuid": "6a19e843-8b1f-45bc-9203-5ba8b25e3246",
-                    "name": "Olutasidenib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 32,
+                "uuid": "6a19e843-8b1f-45bc-9203-5ba8b25e3246",
+                "name": "Olutasidenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -621,7 +630,7 @@
     "manufacturer": "Abbott Molecular, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:38.544484Z",
+    "lastUpdated": "2024-04-06T01:03:38.248210Z",
     "fdaSubmissions": [
       {
         "id": 4,
@@ -635,29 +644,55 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 4,
+            "id": 122,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 4,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 7,
+                "entity": "DRUG",
+                "rule": "147",
+                "name": null
+              },
+              {
+                "id": 8,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9304,
+                "id": 9415,
+                "type": "PROTEIN_CHANGE",
+                "name": "R140L",
+                "alteration": "R140L",
+                "proteinChange": "R140L",
+                "start": 140,
+                "end": 140,
+                "refResidues": "R",
+                "variantResidues": "L",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 23172,
+                    "entrezGeneId": 3418,
+                    "hugoSymbol": "IDH2",
+                    "hgncId": "5383"
+                  }
+                ],
+                "consequence": {
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
+                  "isGenerallyTruncating": false,
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
+                }
+              },
+              {
+                "id": 9407,
                 "type": "PROTEIN_CHANGE",
                 "name": "R140Q",
                 "alteration": "R140Q",
@@ -666,13 +701,13 @@
                 "end": 140,
                 "refResidues": "R",
                 "variantResidues": "Q",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -680,12 +715,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9305,
+                "id": 9408,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172G",
                 "alteration": "R172G",
@@ -694,13 +728,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -708,12 +742,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9306,
+                "id": 9409,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172K",
                 "alteration": "R172K",
@@ -722,13 +755,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -736,12 +769,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9307,
+                "id": 9410,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172M",
                 "alteration": "R172M",
@@ -750,13 +782,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -764,12 +796,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9308,
+                "id": 9411,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172S",
                 "alteration": "R172S",
@@ -778,41 +809,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
-                    "entrezGeneId": 3418,
-                    "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
-                  "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 9312,
-                "type": "PROTEIN_CHANGE",
-                "name": "R140L",
-                "alteration": "R140L",
-                "proteinChange": "R140L",
-                "start": 140,
-                "end": 140,
-                "refResidues": "R",
-                "variantResidues": "L",
-                "genes": [
-                  {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -820,12 +823,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9313,
+                "id": 9416,
                 "type": "PROTEIN_CHANGE",
                 "name": "R140G",
                 "alteration": "R140G",
@@ -834,13 +836,13 @@
                 "end": 140,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -848,12 +850,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9314,
+                "id": 9417,
                 "type": "PROTEIN_CHANGE",
                 "name": "R140W",
                 "alteration": "R140W",
@@ -862,13 +863,13 @@
                 "end": 140,
                 "refResidues": "R",
                 "variantResidues": "W",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -876,12 +877,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9315,
+                "id": 9418,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172W",
                 "alteration": "R172W",
@@ -890,13 +890,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "W",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -904,32 +904,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 4,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 146,
-                    "uuid": "788cb524-1a76-4280-b6e8-02b07d65f765",
-                    "name": "Enasidenib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 147,
+                "uuid": "788cb524-1a76-4280-b6e8-02b07d65f765",
+                "name": "Enasidenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -953,7 +961,7 @@
     "manufacturer": "Resolution Bioscience, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:00:39.295650Z",
+    "lastUpdated": "2024-04-06T01:03:39.076383Z",
     "fdaSubmissions": [
       {
         "id": 5,
@@ -967,29 +975,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 5,
+            "id": 123,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 5,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 9,
+                "entity": "DRUG",
+                "rule": "121",
+                "name": null
+              },
+              {
+                "id": 10,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -998,13 +1005,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -1012,32 +1019,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 5,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 120,
-                    "uuid": "0a7b3eb1-d1f0-4511-aaac-9a696955bf57",
-                    "name": "Adagrasib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 121,
+                "uuid": "0a7b3eb1-d1f0-4511-aaac-9a696955bf57",
+                "name": "Adagrasib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -1056,7 +1071,7 @@
     "manufacturer": "Myriad Genetic Laboratories, Inc.",
     "indicationDetails": null,
     "platformType": "PCR and Sanger sequencing",
-    "lastUpdated": "2024-01-11T17:00:41.228133Z",
+    "lastUpdated": "2024-04-06T01:03:40.579001Z",
     "fdaSubmissions": [
       {
         "id": 6,
@@ -1070,197 +1085,192 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 6,
+            "id": 124,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 6,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 7,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 11,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 8,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 12,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 6,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 7,
+            "id": 125,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 9,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 10,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 13,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 11,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 14,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 7,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -1276,197 +1286,192 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 8,
+            "id": 126,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 12,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
-              {
-                "id": 13,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 15,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
               },
               {
-                "id": 14,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 16,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 8,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 9,
+            "id": 127,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 15,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 16,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 17,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
               },
               {
-                "id": 17,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 18,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 9,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -1482,169 +1487,172 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 10,
+            "id": 128,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 18,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 19,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 19,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 20,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
               {
-                "id": 10,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 11,
+            "id": 129,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 20,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 21,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 21,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 22,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
               {
-                "id": 11,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -1663,7 +1671,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:42.457238Z",
+    "lastUpdated": "2024-04-06T01:03:41.494590Z",
     "fdaSubmissions": [
       {
         "id": 9,
@@ -1677,29 +1685,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 12,
+            "id": 130,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 22,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 23,
+                "entity": "DRUG",
+                "rule": "4",
+                "name": null
+              },
+              {
+                "id": 24,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -1708,13 +1715,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -1722,32 +1729,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 12,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 4,
-                    "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
-                    "name": "Vemurafenib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 4,
+                "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
+                "name": "Vemurafenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -1763,29 +1778,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 13,
+            "id": 131,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 23,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 25,
+                "entity": "DRUG",
+                "rule": "4+48",
+                "name": null
+              },
+              {
+                "id": 26,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -1794,13 +1808,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -1808,12 +1822,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -1822,13 +1835,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -1836,37 +1849,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 13,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 4,
-                    "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
-                    "name": "Vemurafenib"
-                  },
-                  {
-                    "id": 47,
-                    "uuid": "eb357145-3b18-4aca-b75a-5e18dd2bf4f9",
-                    "name": "Cobimetinib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 4,
+                "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
+                "name": "Vemurafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 48,
+                "uuid": "eb357145-3b18-4aca-b75a-5e18dd2bf4f9",
+                "name": "Cobimetinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -1885,7 +1907,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:42.770910Z",
+    "lastUpdated": "2024-04-06T01:03:42.011315Z",
     "fdaSubmissions": [
       {
         "id": 11,
@@ -1899,29 +1921,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 14,
+            "id": 132,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 24,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 27,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 28,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -1930,13 +1951,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -1944,60 +1965,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 14,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -2016,7 +2044,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:49.091757Z",
+    "lastUpdated": "2024-04-06T01:03:45.151008Z",
     "fdaSubmissions": [
       {
         "id": 12,
@@ -2030,29 +2058,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 15,
+            "id": 133,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 25,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 29,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 30,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -2061,13 +2088,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2075,32 +2102,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 15,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2116,29 +2151,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 16,
+            "id": 134,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 26,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 31,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 32,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2147,13 +2181,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2161,60 +2195,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 16,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2230,29 +2271,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 17,
+            "id": 135,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 27,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 33,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 34,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2261,13 +2301,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2275,60 +2315,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 17,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2344,29 +2391,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 18,
+            "id": 136,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 28,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 35,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 36,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2375,13 +2421,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2389,60 +2435,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 18,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2458,29 +2511,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 19,
+            "id": 137,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 29,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 37,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 38,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2489,13 +2541,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2503,76 +2555,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 19,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 20,
+            "id": 138,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 30,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 39,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 40,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2581,13 +2636,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2595,76 +2650,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 20,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 21,
+            "id": 139,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 31,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 41,
+                "entity": "DRUG",
+                "rule": "59",
+                "name": null
+              },
+              {
+                "id": 42,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2673,13 +2731,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2687,76 +2745,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 21,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 22,
+            "id": 140,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 32,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 43,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 44,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2765,13 +2826,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2779,60 +2840,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 22,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2848,29 +2916,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 23,
+            "id": 141,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 33,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 45,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 46,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -2879,13 +2946,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2893,32 +2960,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 23,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -2934,29 +3009,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 24,
+            "id": 142,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 34,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 47,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 48,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2965,13 +3039,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2979,60 +3053,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 24,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -3051,7 +3132,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:49.431272Z",
+    "lastUpdated": "2024-04-06T01:03:45.593844Z",
     "fdaSubmissions": [
       {
         "id": 19,
@@ -3065,29 +3146,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 25,
+            "id": 143,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 35,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 774,
-                  "code": "FL",
-                  "color": "LimeGreen",
-                  "level": 5,
-                  "mainType": "Mature B-Cell Neoplasms",
-                  "subtype": "Follicular Lymphoma",
-                  "tissue": "Lymphoid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 49,
+                "entity": "DRUG",
+                "rule": "110",
+                "name": null
+              },
+              {
+                "id": 50,
+                "entity": "CANCER_TYPE",
+                "rule": "774",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 7685,
+                "id": 7788,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646H",
                 "alteration": "Y646H",
@@ -3096,13 +3176,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3110,12 +3190,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7686,
+                "id": 7789,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646S",
                 "alteration": "Y646S",
@@ -3124,13 +3203,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3138,12 +3217,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7687,
+                "id": 7790,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646C",
                 "alteration": "Y646C",
@@ -3152,13 +3230,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3166,12 +3244,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7688,
+                "id": 7791,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646F",
                 "alteration": "Y646F",
@@ -3180,13 +3257,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "F",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3194,12 +3271,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7689,
+                "id": 7792,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646N",
                 "alteration": "Y646N",
@@ -3208,13 +3284,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "N",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3222,12 +3298,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7690,
+                "id": 7793,
                 "type": "PROTEIN_CHANGE",
                 "name": "A682G",
                 "alteration": "A682G",
@@ -3236,13 +3311,13 @@
                 "end": 682,
                 "refResidues": "A",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3250,12 +3325,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7697,
+                "id": 7800,
                 "type": "PROTEIN_CHANGE",
                 "name": "A692V",
                 "alteration": "A692V",
@@ -3264,13 +3338,13 @@
                 "end": 692,
                 "refResidues": "A",
                 "variantResidues": "V",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3278,32 +3352,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 25,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 109,
-                    "uuid": "49e07d49-ee64-4049-c09d-37c6ce612cad",
-                    "name": "Tazemetostat"
-                  }
-                ]
+                "id": 774,
+                "code": "FL",
+                "color": "LimeGreen",
+                "level": 5,
+                "mainType": "Mature B-Cell Neoplasms",
+                "subtype": "Follicular Lymphoma",
+                "tissue": "Lymphoid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 110,
+                "uuid": "49e07d49-ee64-4049-c09d-37c6ce612cad",
+                "name": "Tazemetostat",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -3322,7 +3404,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:50.367695Z",
+    "lastUpdated": "2024-04-06T01:03:45.998378Z",
     "fdaSubmissions": [
       {
         "id": 20,
@@ -3336,29 +3418,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 26,
+            "id": 144,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 36,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 51,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 52,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3367,13 +3448,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3381,64 +3462,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 26,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               },
               {
-                "id": 27,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 27,
+            "id": 145,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 37,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 53,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 54,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3447,13 +3522,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3461,48 +3536,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 28,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 29,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -3521,7 +3594,7 @@
     "manufacturer": "EntroGen, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:51.350125Z",
+    "lastUpdated": "2024-04-06T01:03:46.438126Z",
     "fdaSubmissions": [
       {
         "id": 21,
@@ -3535,29 +3608,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 28,
+            "id": 146,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 38,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 55,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 56,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3566,13 +3638,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3580,64 +3652,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 30,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 31,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 29,
+            "id": 147,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 39,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 57,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 58,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
+                "id": 12919,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3646,13 +3712,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 17596,
+                    "id": 17611,
                     "entrezGeneId": 4893,
                     "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "hgncId": "7989"
                   }
                 ],
                 "consequence": {
@@ -3660,48 +3726,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 32,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 33,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -3720,7 +3784,7 @@
     "manufacturer": "Foundation Medicine, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:00:52.172923Z",
+    "lastUpdated": "2024-04-06T01:03:46.999833Z",
     "fdaSubmissions": [
       {
         "id": 22,
@@ -3734,197 +3798,192 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 30,
+            "id": 148,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 40,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 41,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 59,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
               },
               {
-                "id": 42,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 60,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 34,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 31,
+            "id": 149,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 43,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 44,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 61,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
               },
               {
-                "id": 45,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 62,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 35,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -3943,7 +4002,7 @@
     "manufacturer": "Foundation Medicine, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:02.995848Z",
+    "lastUpdated": "2024-04-06T01:03:56.584424Z",
     "fdaSubmissions": [
       {
         "id": 27,
@@ -3957,29 +4016,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 51,
+            "id": 169,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 69,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 115,
-                  "code": "CHOL",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 101,
+                "entity": "DRUG",
+                "rule": "28",
+                "name": null
+              },
+              {
+                "id": 102,
+                "entity": "CANCER_TYPE",
+                "rule": "115",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8055,
+                "id": 8158,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -3988,46 +4046,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7998,
+                    "id": 8029,
                     "entrezGeneId": 2263,
                     "hugoSymbol": "FGFR2",
-                    "hgncId": "3689",
-                    "evidences": null
+                    "hgncId": "3689"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 59,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 27,
-                    "uuid": "b205be87-a4cb-48d2-904b-3cac09f51d96",
-                    "name": "Pemigatinib"
-                  }
-                ]
+                "id": 115,
+                "code": "CHOL",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Hepatobiliary Cancer",
+                "subtype": "Cholangiocarcinoma",
+                "tissue": "Biliary Tract",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 28,
+                "uuid": "b205be87-a4cb-48d2-904b-3cac09f51d96",
+                "name": "Pemigatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -4043,29 +4109,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 32,
+            "id": 152,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 46,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 67,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 68,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -4074,13 +4139,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4088,76 +4153,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 36,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 33,
+            "id": 150,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 47,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 63,
+                "entity": "DRUG",
+                "rule": "59",
+                "name": null
+              },
+              {
+                "id": 64,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -4166,13 +4234,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4180,76 +4248,159 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 37,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
               }
-            ]
-          },
-          {
-            "id": 34,
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 159,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 48,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
+                "id": 81,
+                "entity": "DRUG",
+                "rule": "39+149+104",
+                "name": null
+              },
+              {
+                "id": 82,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 6182,
+                "type": "COPY_NUMBER_ALTERATION",
+                "name": "Amplification",
+                "alteration": "Amplification",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 7706,
+                    "entrezGeneId": 2064,
+                    "hugoSymbol": "ERBB2",
+                    "hgncId": "3430"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
               }
             ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
+              },
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
+              },
+              {
+                "id": 149,
+                "uuid": "b89a5c78-1828-4adf-a9fa-937f99410c1d",
+                "name": "Pertuzumab",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 151,
+            "name": null,
+            "rules": [
+              {
+                "id": 65,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 66,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
+              }
+            ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -4258,13 +4409,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4272,76 +4423,147 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 38,
-                "name": null,
-                "drugs": [
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 160,
+            "name": null,
+            "rules": [
+              {
+                "id": 83,
+                "entity": "DRUG",
+                "rule": "7",
+                "name": null
+              },
+              {
+                "id": 84,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 6182,
+                "type": "COPY_NUMBER_ALTERATION",
+                "name": "Amplification",
+                "alteration": "Amplification",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
+                    "id": 7706,
+                    "entrezGeneId": 2064,
+                    "hugoSymbol": "ERBB2",
+                    "hgncId": "3430"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 7,
+                "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
+                "name": "Ado-Trastuzumab Emtansine",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 35,
+            "id": 153,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 49,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 69,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 70,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -4350,13 +4572,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4364,48 +4586,52 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 39,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 36,
+            "id": 154,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 50,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 71,
+                "entity": "DRUG",
+                "rule": "99",
+                "name": null
+              },
+              {
+                "id": 72,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
+                "id": 662,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -4414,77 +4640,81 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
+                    "id": 21829,
                     "entrezGeneId": 238,
                     "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 40,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 98,
-                    "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
-                    "name": "Alectinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 99,
+                "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
+                "name": "Alectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 45,
+            "id": 155,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 59,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 73,
+                "entity": "DRUG",
+                "rule": "3",
+                "name": null
+              },
+              {
+                "id": 74,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
-                "type": "NA",
-                "name": "Wildtype",
-                "alteration": "Wildtype",
+                "id": 662,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
                 "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 17596,
-                    "entrezGeneId": 4893,
-                    "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "id": 21829,
+                    "entrezGeneId": 238,
+                    "hugoSymbol": "ALK",
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
@@ -4492,64 +4722,120 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 52,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 3,
+                "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
+                "name": "Crizotinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 156,
+            "name": null,
+            "rules": [
+              {
+                "id": 75,
+                "entity": "DRUG",
+                "rule": "90",
+                "name": null
               },
               {
-                "id": 53,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
+                "id": 76,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 662,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
+                    "id": 21829,
+                    "entrezGeneId": 238,
+                    "hugoSymbol": "ALK",
+                    "hgncId": "427"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 90,
+                "uuid": "5e9aa568-30cf-48ef-b9ce-18851af2f622",
+                "name": "Ceritinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 46,
+            "id": 164,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 60,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 91,
+                "entity": "DRUG",
+                "rule": "123",
+                "name": null
+              },
+              {
+                "id": 92,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -4558,13 +4844,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -4572,12 +4858,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -4586,13 +4871,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -4600,399 +4885,200 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 54,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 37,
+            "id": 157,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 51,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 77,
+                "entity": "DRUG",
+                "rule": "15+123",
+                "name": null
+              },
+              {
+                "id": 78,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
-                "proteinChange": "",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
+                "id": 1491,
+                "type": "PROTEIN_CHANGE",
+                "name": "V600E",
+                "alteration": "V600E",
+                "proteinChange": "V600E",
+                "start": 600,
+                "end": 600,
+                "refResidues": "V",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
-                    "entrezGeneId": 238,
-                    "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "id": 41135,
+                    "entrezGeneId": 673,
+                    "hugoSymbol": "BRAF",
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
-              {
-                "id": 41,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 3,
-                    "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
-                    "name": "Crizotinib"
-                  }
-                ]
-              }
-            ]
-          },
-          {
-            "id": 38,
-            "name": null,
-            "associationCancerTypes": [
+            "cancerTypes": [
               {
-                "id": 52,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
               }
             ],
-            "alterations": [
+            "drugs": [
               {
-                "id": 559,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
-                "proteinChange": "",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 21832,
-                    "entrezGeneId": 238,
-                    "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
-                  "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
+                "id": 15,
+                "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
+                "name": "Dabrafenib",
+                "fdaDrugs": null
+              },
               {
-                "id": 42,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 89,
-                    "uuid": "5e9aa568-30cf-48ef-b9ce-18851af2f622",
-                    "name": "Ceritinib"
-                  }
-                ]
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 39,
+            "id": 163,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 53,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
-              }
-            ],
-            "alterations": [
-              {
-                "id": 1388,
-                "type": "PROTEIN_CHANGE",
-                "name": "V600E",
-                "alteration": "V600E",
-                "proteinChange": "V600E",
-                "start": 600,
-                "end": 600,
-                "refResidues": "V",
-                "variantResidues": "E",
-                "genes": [
-                  {
-                    "id": 41259,
-                    "entrezGeneId": 673,
-                    "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
-                  "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
+            "rules": [
               {
-                "id": 43,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 15,
-                    "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
-                    "name": "Dabrafenib"
-                  },
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
-              }
-            ]
-          },
-          {
-            "id": 40,
-            "name": null,
-            "associationCancerTypes": [
+                "id": 89,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
               {
-                "id": 54,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 90,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
-                "type": "COPY_NUMBER_ALTERATION",
-                "name": "Amplification",
-                "alteration": "Amplification",
+                "id": 12919,
+                "type": "NA",
+                "name": "Wildtype",
+                "alteration": "Wildtype",
                 "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
-                    "entrezGeneId": 2064,
-                    "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "id": 17611,
+                    "entrezGeneId": 4893,
+                    "hugoSymbol": "NRAS",
+                    "hgncId": "7989"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
-              {
-                "id": 44,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
-              },
-              {
-                "id": 45,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
-              }
-            ]
-          },
-          {
-            "id": 41,
-            "name": null,
-            "associationCancerTypes": [
+            "cancerTypes": [
               {
-                "id": 55,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
               }
             ],
-            "alterations": [
+            "drugs": [
               {
-                "id": 6079,
-                "type": "COPY_NUMBER_ALTERATION",
-                "name": "Amplification",
-                "alteration": "Amplification",
-                "proteinChange": "",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 7677,
-                    "entrezGeneId": 2064,
-                    "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
-                  "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
+              },
               {
-                "id": 46,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 148,
-                    "uuid": "b89a5c78-1828-4adf-a9fa-937f99410c1d",
-                    "name": "Pertuzumab"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 44,
+            "id": 161,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 58,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 85,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 86,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -5001,13 +5087,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -5015,64 +5101,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 50,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               },
               {
-                "id": 51,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 43,
+            "id": 162,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 57,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 87,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 88,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -5081,13 +5161,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -5095,64 +5175,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 48,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 49,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 42,
+            "id": 158,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 56,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 79,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 80,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -5161,46 +5235,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 47,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 7,
-                    "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
-                    "name": "Ado-Trastuzumab Emtansine"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
+              },
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -5216,164 +5304,365 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 47,
+            "id": 165,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 61,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 62,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 93,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 63,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 94,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 55,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 48,
+            "id": 166,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 64,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
-              {
-                "id": 65,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 95,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 66,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 96,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 96,
+        "number": "P170019",
+        "supplementNumber": "S043",
+        "deviceName": "FoundationOne CDx (F1CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2023-03-01T05:00:00Z",
+        "decisionDate": "2023-10-05T04:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of RET fusions in patients with solid tumors who may benefit from treatment with RETEVMO® (selpercatinib).",
+        "curated": false,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 264,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 15740,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 5121,
+                    "entrezGeneId": 5979,
+                    "hugoSymbol": "RET",
+                    "hgncId": "9967"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 97,
+        "number": "P170019",
+        "supplementNumber": "S011",
+        "deviceName": "FoundationOne CDx (F1CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2019-10-16T04:00:00Z",
+        "decisionDate": "2020-05-05T04:00:00Z",
+        "description": "Approval to include a companion diagnostic indication for detection of MET single nucleotide variants (SNVs) and indels that lead to MET exon 14 skipping in non-small cell lung cancer patients who may benefit from treatment with TABRECTA (capmatinib).",
+        "curated": false,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 263,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 11231,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010splice",
+                "alteration": "963_1010splice",
+                "proteinChange": "963_1010splice",
+                "start": 963,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 27,
+                  "term": "SPLICE_REGION_VARIANT",
+                  "name": "Splice Region Variant",
+                  "isGenerallyTruncating": true,
+                  "description": "A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron"
+                }
+              },
+              {
+                "id": 11238,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010del",
+                "alteration": "963_1010del",
+                "proteinChange": "963_1010del",
+                "start": 963,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 11,
+                  "term": "INFRAME_DELETION",
+                  "name": "Inframe Deletion",
+                  "isGenerallyTruncating": false,
+                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence"
+                }
+              },
+              {
+                "id": 11239,
+                "type": "PROTEIN_CHANGE",
+                "name": "Exon 14 Deletion",
+                "alteration": "Exon 14 Deletion",
+                "proteinChange": "Exon 14 Deletion",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
                   }
                 ],
                 "consequence": {
@@ -5381,32 +5670,199 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
+                }
+              },
+              {
+                "id": 11240,
+                "type": "PROTEIN_CHANGE",
+                "name": "D1010",
+                "alteration": "D1010",
+                "proteinChange": "D1010",
+                "start": 1010,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": "",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 56,
-                "name": null,
-                "drugs": [
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 82,
+                "uuid": "8ddbbd88-3730-4ea2-8cba-b5038d250fd1",
+                "name": "Capmatinib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 32,
+        "number": "P170019",
+        "supplementNumber": "S030",
+        "deviceName": "FoundationOne CDx (F1CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2021-07-01T00:00:00Z",
+        "decisionDate": "2022-01-19T00:00:00Z",
+        "description": "Approval to expand the intended use of FoundationOne CDx (F1CDx) to expand the intended use of FoundationOne CDx (F1CDx) to include a companion diagnostic indication for identifying patients with BRAF V600 mutation-positive unresectable or metastatic melanoma, who may benefit from treatment with atezolizumab (Tecentriq) in combination with cobimetinib and vemurafenib.",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 176,
+            "name": null,
+            "rules": [
+              {
+                "id": 115,
+                "entity": "DRUG",
+                "rule": "4+46+48",
+                "name": null
+              },
+              {
+                "id": 116,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 1494,
+                "type": "PROTEIN_CHANGE",
+                "name": "V600",
+                "alteration": "V600",
+                "proteinChange": "V600",
+                "start": 600,
+                "end": 600,
+                "refResidues": "V",
+                "variantResidues": "",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 41135,
+                    "entrezGeneId": 673,
+                    "hugoSymbol": "BRAF",
+                    "hgncId": "1097"
+                  }
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
+                }
+              },
+              {
+                "id": 1626,
+                "type": "PROTEIN_CHANGE",
+                "name": "V600",
+                "alteration": "V600 {excluding V600E ; V600K}",
+                "proteinChange": "V600",
+                "start": 600,
+                "end": 600,
+                "refResidues": "V",
+                "variantResidues": "",
+                "flags": null,
+                "genes": [
                   {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
+                    "id": 41135,
+                    "entrezGeneId": 673,
+                    "hugoSymbol": "BRAF",
+                    "hgncId": "1097"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 4,
+                "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
+                "name": "Vemurafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 46,
+                "uuid": "9a54c73a-15d8-41a8-8ea0-730f874831da",
+                "name": "Atezolizumab",
+                "fdaDrugs": null
+              },
+              {
+                "id": 48,
+                "uuid": "eb357145-3b18-4aca-b75a-5e18dd2bf4f9",
+                "name": "Cobimetinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -5422,44 +5878,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 49,
+            "id": 167,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 67,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 97,
+                "entity": "DRUG",
+                "rule": "84+33",
+                "name": null
+              },
+              {
+                "id": 98,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13431,
+                "id": 13532,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
+                "variantResidues": "D",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5467,12 +5922,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13426,
+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -5481,13 +5935,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5495,12 +5949,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13427,
+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -5509,13 +5962,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5523,27 +5976,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13428,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545A",
-                "alteration": "E545A",
-                "proteinChange": "E545A",
-                "start": 545,
-                "end": 545,
-                "refResidues": "E",
-                "variantResidues": "A",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
+                "start": 1047,
+                "end": 1047,
+                "refResidues": "H",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5551,27 +6003,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13429,
+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545A",
+                "alteration": "E545A",
+                "proteinChange": "E545A",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "A",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5579,12 +6030,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545G",
                 "alteration": "E545G",
@@ -5593,13 +6043,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5607,27 +6057,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546E",
-                "alteration": "Q546E",
-                "proteinChange": "Q546E",
-                "start": 546,
-                "end": 546,
-                "refResidues": "Q",
-                "variantResidues": "E",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
+                "start": 545,
+                "end": 545,
+                "refResidues": "E",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5635,27 +6084,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546R",
-                "alteration": "Q546R",
-                "proteinChange": "Q546R",
+                "name": "Q546E",
+                "alteration": "Q546E",
+                "proteinChange": "Q546E",
                 "start": 546,
                 "end": 546,
                 "refResidues": "Q",
-                "variantResidues": "R",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5663,27 +6111,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047R",
+                "alteration": "H1047R",
+                "proteinChange": "H1047R",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5691,27 +6138,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047R",
-                "alteration": "H1047R",
-                "proteinChange": "H1047R",
-                "start": 1047,
-                "end": 1047,
-                "refResidues": "H",
+                "name": "Q546R",
+                "alteration": "Q546R",
+                "proteinChange": "Q546R",
+                "start": 546,
+                "end": 546,
+                "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5719,27 +6165,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -5747,37 +6192,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 57,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -5793,29 +6247,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 50,
+            "id": 168,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 68,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 99,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 100,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -5824,13 +6277,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -5838,524 +6291,715 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 58,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 28,
+        "id": 34,
         "number": "P170019",
-        "supplementNumber": "S015",
-        "deviceName": "FoundationOne CDx",
+        "supplementNumber": "S048",
+        "deviceName": "FoundationOne CDx (F1CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2019-12-16T00:00:00Z",
-        "decisionDate": "2020-05-19T00:00:00Z",
-        "description": "Approval to expand the intended use of FoundationOne®CDx to include a companion diagnostic indication for homologous recombination repair (HHR) gene alterations in patients with metastatic castration resistant prostate cancer who may benefit from treatment with Lynparza®(olaparib).",
+        "dateReceived": "2023-07-03T00:00:00Z",
+        "decisionDate": "2023-11-16T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of PIK3CA/AKT1/PTEN-alterations in patients with breast cancer who may benefit from treatment with TRUQAP™(capivasertib) in combination with FASLODEX®(fulvestrant).",
         "curated": true,
-        "genetic": false,
+        "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 52,
+            "id": 178,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 70,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 119,
+                "entity": "DRUG",
+                "rule": "133+33",
+                "name": null
               },
               {
-                "id": 71,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 120,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1235,
-                "type": "PROTEIN_CHANGE",
+                "id": 13540,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 28520,
-                    "entrezGeneId": 580,
-                    "hugoSymbol": "BARD1",
-                    "hgncId": "952",
-                    "evidences": null
+                    "id": 39811,
+                    "entrezGeneId": 5290,
+                    "hugoSymbol": "PIK3CA",
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 885,
-                "type": "PROTEIN_CHANGE",
+                "id": 13541,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23673,
-                    "entrezGeneId": 472,
-                    "hugoSymbol": "ATM",
-                    "hgncId": "795",
-                    "evidences": null
+                    "id": 39811,
+                    "entrezGeneId": 5290,
+                    "hugoSymbol": "PIK3CA",
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
               },
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 133,
+                "uuid": "beb74d50-0622-4df5-af40-a7acaa60beaa",
+                "name": "Capivasertib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 271,
+            "name": null,
+            "rules": [
+              {
+                "id": 287,
+                "entity": "DRUG",
+                "rule": "133+33",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 14892,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
-                    "entrezGeneId": 672,
-                    "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "id": 500,
+                    "entrezGeneId": 5728,
+                    "hugoSymbol": "PTEN",
+                    "hgncId": "9588"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
               },
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 133,
+                "uuid": "beb74d50-0622-4df5-af40-a7acaa60beaa",
+                "name": "Capivasertib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 28,
+        "number": "P170019",
+        "supplementNumber": "S015",
+        "deviceName": "FoundationOne CDx",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2019-12-16T00:00:00Z",
+        "decisionDate": "2020-05-19T00:00:00Z",
+        "description": "Approval to expand the intended use of FoundationOne®CDx to include a companion diagnostic indication for homologous recombination repair (HHR) gene alterations in patients with metastatic castration resistant prostate cancer who may benefit from treatment with Lynparza®(olaparib).",
+        "curated": true,
+        "genetic": false,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 170,
+            "name": null,
+            "rules": [
+              {
+                "id": 103,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
+              },
+              {
+                "id": 104,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 1338,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
-                    "entrezGeneId": 675,
-                    "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "id": 28482,
+                    "entrezGeneId": 580,
+                    "hugoSymbol": "BARD1",
+                    "hgncId": "952"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 3541,
-                "type": "PROTEIN_CHANGE",
+                "id": 988,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 12002,
-                    "entrezGeneId": 83990,
-                    "hugoSymbol": "BRIP1",
-                    "hgncId": "20473",
-                    "evidences": null
+                    "id": 23657,
+                    "entrezGeneId": 472,
+                    "hugoSymbol": "ATM",
+                    "hgncId": "795"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 3963,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30505,
-                    "entrezGeneId": 51755,
-                    "hugoSymbol": "CDK12",
-                    "hgncId": "24224",
-                    "evidences": null
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
-                  "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 4191,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32894,
-                    "entrezGeneId": 1111,
-                    "hugoSymbol": "CHEK1",
-                    "hgncId": "1925",
-                    "evidences": null
+                    "id": 32458,
+                    "entrezGeneId": 675,
+                    "hugoSymbol": "BRCA2",
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 15432,
-                "type": "PROTEIN_CHANGE",
+                "id": 15527,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 4289,
-                    "entrezGeneId": 8438,
-                    "hugoSymbol": "RAD54L",
-                    "hgncId": "9826",
-                    "evidences": null
+                    "id": 28537,
+                    "entrezGeneId": 5892,
+                    "hugoSymbol": "RAD51D",
+                    "hgncId": "9823"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 4211,
-                "type": "PROTEIN_CHANGE",
+                "id": 3644,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 33323,
-                    "entrezGeneId": 11200,
-                    "hugoSymbol": "CHEK2",
-                    "hgncId": "16627",
-                    "evidences": null
+                    "id": 12030,
+                    "entrezGeneId": 83990,
+                    "hugoSymbol": "BRIP1",
+                    "hgncId": "20473"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 15412,
-                "type": "PROTEIN_CHANGE",
+                "id": 4066,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 35718,
-                    "entrezGeneId": 5889,
-                    "hugoSymbol": "RAD51C",
-                    "hgncId": "9820",
-                    "evidences": null
+                    "id": 30456,
+                    "entrezGeneId": 51755,
+                    "hugoSymbol": "CDK12",
+                    "hgncId": "24224"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 7746,
-                "type": "PROTEIN_CHANGE",
+                "id": 13255,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 722,
-                    "entrezGeneId": 55120,
-                    "hugoSymbol": "FANCL",
-                    "hgncId": "20748",
-                    "evidences": null
+                    "id": 21401,
+                    "entrezGeneId": 79728,
+                    "hugoSymbol": "PALB2",
+                    "hgncId": "26144"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 13152,
-                "type": "PROTEIN_CHANGE",
+                "id": 4294,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21404,
-                    "entrezGeneId": 79728,
-                    "hugoSymbol": "PALB2",
-                    "hgncId": "26144",
-                    "evidences": null
+                    "id": 32832,
+                    "entrezGeneId": 1111,
+                    "hugoSymbol": "CHEK1",
+                    "hgncId": "1925"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 15424,
-                "type": "PROTEIN_CHANGE",
+                "id": 4314,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 28575,
-                    "entrezGeneId": 5892,
-                    "hugoSymbol": "RAD51D",
-                    "hgncId": "9823",
-                    "evidences": null
+                    "id": 33261,
+                    "entrezGeneId": 11200,
+                    "hugoSymbol": "CHEK2",
+                    "hgncId": "16627"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 15396,
-                "type": "PROTEIN_CHANGE",
+                "id": 15535,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 4301,
+                    "entrezGeneId": 8438,
+                    "hugoSymbol": "RAD54L",
+                    "hgncId": "9826"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              },
+              {
+                "id": 15515,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 35622,
+                    "entrezGeneId": 5889,
+                    "hugoSymbol": "RAD51C",
+                    "hgncId": "9820"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              },
+              {
+                "id": 7849,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 724,
+                    "entrezGeneId": 55120,
+                    "hugoSymbol": "FANCL",
+                    "hgncId": "20748"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              },
+              {
+                "id": 15499,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 2907,
+                    "id": 2918,
                     "entrezGeneId": 5890,
                     "hugoSymbol": "RAD51B",
-                    "hgncId": "9822",
-                    "evidences": null
+                    "hgncId": "9822"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
               {
-                "id": 60,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -6371,44 +7015,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 53,
+            "id": 171,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 72,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 105,
+                "entity": "DRUG",
+                "rule": "85",
+                "name": null
+              },
+              {
+                "id": 106,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13128,
+                "id": 22639,
                 "type": "NA",
                 "name": "Tumor Mutational Burden-High",
-                "alteration": "TMB-H",
-                "proteinChange": "TMB-H",
+                "alteration": "Tumor Mutational Burden-High",
+                "proteinChange": "Tumor Mutational Burden-High",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 42082,
+                    "id": 42192,
                     "entrezGeneId": -2,
                     "hugoSymbol": "Other Biomarkers",
-                    "hgncId": null,
-                    "evidences": null
+                    "hgncId": null
                   }
                 ],
                 "consequence": {
@@ -6416,348 +7059,349 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 61,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 84,
-                    "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
-                    "name": "Pembrolizumab"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 85,
+                "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
+                "name": "Pembrolizumab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 35,
+        "id": 36,
         "number": "P170019",
-        "supplementNumber": "S014",
-        "deviceName": "FoundationOne CDx",
+        "supplementNumber": "S042",
+        "deviceName": "FoundationOne CDx (F1CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2019-12-16T00:00:00Z",
-        "decisionDate": "2022-06-07T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic indication for NTRK1, NTRK2, and NTRK3 fusions in patients with solid tumors and for ROS1 fusions in patients with non-small cell lung cancer who may benefit from treatment with ROZLYTREK® (entrectinib).",
+        "dateReceived": "2023-02-28T00:00:00Z",
+        "decisionDate": "2023-08-11T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for identifying prostate cancer patients with BRCA1, BRCA2 alterations who may benefit from treatment with AKEEGA (niraparib + abiraterone acetate).",
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 61,
+            "id": 273,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 80,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 289,
+                "entity": "DRUG",
+                "rule": "38+40+27",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12991,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
+                "id": 2054,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
                 "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20529,
-                    "entrezGeneId": 4914,
-                    "hugoSymbol": "NTRK1",
-                    "hgncId": "8031",
-                    "evidences": null
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 69,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 27,
+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
+                "fdaDrugs": null
+              },
+              {
+                "id": 38,
+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 62,
+            "id": 274,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 81,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 290,
+                "entity": "DRUG",
+                "rule": "38+40+27",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13050,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
+                "id": 2677,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
                 "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20530,
-                    "entrezGeneId": 4915,
-                    "hugoSymbol": "NTRK2",
-                    "hgncId": "8032",
-                    "evidences": null
+                    "id": 32458,
+                    "entrezGeneId": 675,
+                    "hugoSymbol": "BRCA2",
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
-              {
-                "id": 70,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
-              }
-            ]
-          },
-          {
-            "id": 63,
-            "name": null,
-            "associationCancerTypes": [
+            "cancerTypes": [
               {
-                "id": 82,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
               }
             ],
-            "alterations": [
+            "drugs": [
               {
-                "id": 13070,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
-                "proteinChange": "",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 39108,
-                    "entrezGeneId": 4916,
-                    "hugoSymbol": "NTRK3",
-                    "hgncId": "8033",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
-                  "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
+                "id": 27,
+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
+                "fdaDrugs": null
+              },
               {
-                "id": 71,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 38,
+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
               }
             ]
-          },
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 33,
+        "number": "P170019",
+        "supplementNumber": "S039",
+        "deviceName": "FoundationOne CDx, F1CDx",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2023-01-30T00:00:00Z",
+        "decisionDate": "2023-10-11T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of BRAF V600E in patients with non-small cell lung cancer who may benefit from treatment with BRAFTOVI® (encorafenib) in combination with MEKTOVI® (binimetinib). ",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
           {
-            "id": 64,
+            "id": 177,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 83,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 117,
+                "entity": "DRUG",
+                "rule": "118+120",
+                "name": null
+              },
+              {
+                "id": 118,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15858,
-                "type": "STRUCTURAL_VARIANT",
-                "name": "Fusions",
-                "alteration": "Fusions",
-                "proteinChange": "",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
+                "id": 1491,
+                "type": "PROTEIN_CHANGE",
+                "name": "V600E",
+                "alteration": "V600E",
+                "proteinChange": "V600E",
+                "start": 600,
+                "end": 600,
+                "refResidues": "V",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 6685,
-                    "entrezGeneId": 6098,
-                    "hugoSymbol": "ROS1",
-                    "hgncId": "10261",
-                    "evidences": null
+                    "id": 41135,
+                    "entrezGeneId": 673,
+                    "hugoSymbol": "BRAF",
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 72,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 120,
+                "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
+                "name": "Binimetinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 30,
+        "id": 35,
         "number": "P170019",
-        "supplementNumber": "S017",
-        "deviceName": "FoundationOne CDx (F1CDx)",
+        "supplementNumber": "S014",
+        "deviceName": "FoundationOne CDx",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2020-01-31T00:00:00Z",
-        "decisionDate": "2020-10-23T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include NTRK1/2/3 fusions in patients with solid tumors who may benefit from treatment with VITRAKVI® (larotrectinib).",
+        "dateReceived": "2019-12-16T00:00:00Z",
+        "decisionDate": "2022-06-07T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic indication for NTRK1, NTRK2, and NTRK3 fusions in patients with solid tumors and for ROS1 fusions in patients with non-small cell lung cancer who may benefit from treatment with ROZLYTREK® (entrectinib).",
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 54,
+            "id": 179,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 73,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 121,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 122,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12991,
+                "id": 13094,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -6766,62 +7410,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20529,
+                    "id": 20523,
                     "entrezGeneId": 4914,
                     "hugoSymbol": "NTRK1",
-                    "hgncId": "8031",
-                    "evidences": null
+                    "hgncId": "8031"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 62,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 43,
-                    "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
-                    "name": "Larotrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 55,
+            "id": 180,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 74,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 123,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 124,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13050,
+                "id": 13153,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -6830,62 +7478,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20530,
+                    "id": 20524,
                     "entrezGeneId": 4915,
                     "hugoSymbol": "NTRK2",
-                    "hgncId": "8032",
-                    "evidences": null
+                    "hgncId": "8032"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 63,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 43,
-                    "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
-                    "name": "Larotrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 56,
+            "id": 181,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 75,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 125,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 126,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13070,
+                "id": 13173,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -6894,578 +7546,403 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39108,
+                    "id": 38985,
                     "entrezGeneId": 4916,
                     "hugoSymbol": "NTRK3",
-                    "hgncId": "8033",
-                    "evidences": null
+                    "hgncId": "8033"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 64,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 43,
-                    "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
-                    "name": "Larotrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
-          }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
-      },
-      {
-        "id": 31,
-        "number": "P170019",
-        "supplementNumber": "S029",
-        "deviceName": "FoundationOne CDx (F1CDx)",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2021-04-19T00:00:00Z",
-        "decisionDate": "2022-02-18T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of microsatellite instability High (MSI-H) status in patients with solid tumors who may benefit from treatment with KEYTRUDA® (pembrolizumab).",
-        "curated": true,
-        "genetic": false,
-        "note": null,
-        "associations": [
+          },
           {
-            "id": 57,
+            "id": 182,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 76,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 127,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 128,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13127,
-                "type": "NA",
-                "name": "Microsatellite Instability-High",
-                "alteration": "MSI-H",
-                "proteinChange": "MSI-H",
+                "id": 15961,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 42082,
-                    "entrezGeneId": -2,
-                    "hugoSymbol": "Other Biomarkers",
-                    "hgncId": null,
-                    "evidences": null
+                    "id": 6704,
+                    "entrezGeneId": 6098,
+                    "hugoSymbol": "ROS1",
+                    "hgncId": "10261"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 65,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 84,
-                    "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
-                    "name": "Pembrolizumab"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 32,
+        "id": 30,
         "number": "P170019",
-        "supplementNumber": "S030",
+        "supplementNumber": "S017",
         "deviceName": "FoundationOne CDx (F1CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2021-07-01T00:00:00Z",
-        "decisionDate": "2022-01-19T00:00:00Z",
-        "description": "Approval to expand the intended use of FoundationOne CDx (F1CDx) to expand the intended use of FoundationOne CDx (F1CDx) to include a companion diagnostic indication for identifying patients with BRAF V600 mutation-positive unresectable or metastatic melanoma, who may benefit from treatment with atezolizumab (Tecentriq) in combination with cobimetinib and vemurafenib.",
+        "dateReceived": "2020-01-31T00:00:00Z",
+        "decisionDate": "2020-10-23T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include NTRK1/2/3 fusions in patients with solid tumors who may benefit from treatment with VITRAKVI® (larotrectinib).",
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 58,
+            "id": 172,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 77,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 107,
+                "entity": "DRUG",
+                "rule": "44",
+                "name": null
+              },
+              {
+                "id": 108,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1391,
-                "type": "PROTEIN_CHANGE",
-                "name": "V600",
-                "alteration": "V600",
-                "proteinChange": "V600",
-                "start": 600,
-                "end": 600,
-                "refResidues": "V",
-                "variantResidues": "",
-                "genes": [
-                  {
-                    "id": 41259,
-                    "entrezGeneId": 673,
-                    "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
-                  }
+                "id": 13094,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20523,
+                    "entrezGeneId": 4914,
+                    "hugoSymbol": "NTRK1",
+                    "hgncId": "8031"
+                  }
                 ],
                 "consequence": {
-                  "id": 17,
-                  "term": "NA",
-                  "name": "NA",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 66,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 4,
-                    "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
-                    "name": "Vemurafenib"
-                  },
-                  {
-                    "id": 45,
-                    "uuid": "9a54c73a-15d8-41a8-8ea0-730f874831da",
-                    "name": "Atezolizumab"
-                  },
-                  {
-                    "id": 47,
-                    "uuid": "eb357145-3b18-4aca-b75a-5e18dd2bf4f9",
-                    "name": "Cobimetinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
               }
             ]
-          }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
-      },
-      {
-        "id": 36,
-        "number": "P170019",
-        "supplementNumber": "S042",
-        "deviceName": "FoundationOne CDx (F1CDx)",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2023-02-28T00:00:00Z",
-        "decisionDate": "2023-08-11T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for identifying prostate cancer patients with BRCA1, BRCA2 alterations who may benefit from treatment with AKEEGA (niraparib + abiraterone acetate).",
-        "curated": true,
-        "genetic": true,
-        "note": null,
-        "associations": [
+          },
           {
-            "id": 65,
+            "id": 173,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 84,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 85,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 109,
+                "entity": "DRUG",
+                "rule": "44",
+                "name": null
               },
               {
-                "id": 86,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 110,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "id": 13153,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
-                    "entrezGeneId": 672,
-                    "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "id": 20524,
+                    "entrezGeneId": 4915,
+                    "hugoSymbol": "NTRK2",
+                    "hgncId": "8032"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 73,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 37,
-                    "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
-                    "name": "Niraparib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 66,
+            "id": 174,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 87,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 88,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 111,
+                "entity": "DRUG",
+                "rule": "44",
+                "name": null
               },
               {
-                "id": 89,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 112,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "id": 13173,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
-                    "entrezGeneId": 675,
-                    "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "id": 38985,
+                    "entrezGeneId": 4916,
+                    "hugoSymbol": "NTRK3",
+                    "hgncId": "8033"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
-              {
-                "id": 74,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 37,
-                    "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
-                    "name": "Niraparib"
-                  }
-                ]
-              }
-            ]
-          }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
-      },
-      {
-        "id": 33,
-        "number": "P170019",
-        "supplementNumber": "S039",
-        "deviceName": "FoundationOne CDx, F1CDx",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2023-01-30T00:00:00Z",
-        "decisionDate": "2023-10-11T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of BRAF V600E in patients with non-small cell lung cancer who may benefit from treatment with BRAFTOVI® (encorafenib) in combination with MEKTOVI® (binimetinib). ",
-        "curated": true,
-        "genetic": true,
-        "note": null,
-        "associations": [
-          {
-            "id": 59,
-            "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 78,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
-              }
-            ],
-            "alterations": [
+            "cancerTypes": [
               {
-                "id": 1388,
-                "type": "PROTEIN_CHANGE",
-                "name": "V600E",
-                "alteration": "V600E",
-                "proteinChange": "V600E",
-                "start": 600,
-                "end": 600,
-                "refResidues": "V",
-                "variantResidues": "E",
-                "genes": [
-                  {
-                    "id": 41259,
-                    "entrezGeneId": 673,
-                    "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
-                  "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
-                }
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
               }
             ],
-            "articles": null,
-            "treatments": [
+            "drugs": [
               {
-                "id": 67,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
-                  {
-                    "id": 119,
-                    "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
-                    "name": "Binimetinib"
-                  }
-                ]
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 34,
+        "id": 31,
         "number": "P170019",
-        "supplementNumber": "S048",
+        "supplementNumber": "S029",
         "deviceName": "FoundationOne CDx (F1CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2023-07-03T00:00:00Z",
-        "decisionDate": "2023-11-16T00:00:00Z",
-        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of PIK3CA/AKT1/PTEN-alterations in patients with breast cancer who may benefit from treatment with TRUQAP™(capivasertib) in combination with FASLODEX®(fulvestrant).",
+        "dateReceived": "2021-04-19T00:00:00Z",
+        "decisionDate": "2022-02-18T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of microsatellite instability High (MSI-H) status in patients with solid tumors who may benefit from treatment with KEYTRUDA® (pembrolizumab).",
         "curated": true,
-        "genetic": true,
+        "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 60,
+            "id": 175,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 79,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 113,
+                "entity": "DRUG",
+                "rule": "85",
+                "name": null
+              },
+              {
+                "id": 114,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13438,
-                "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "id": 22640,
+                "type": "NA",
+                "name": "Microsatellite Instability-High",
+                "alteration": "Microsatellite Instability-High",
+                "proteinChange": "Microsatellite Instability-High",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
-                    "entrezGeneId": 5290,
-                    "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "id": 42192,
+                    "entrezGeneId": -2,
+                    "hugoSymbol": "Other Biomarkers",
+                    "hgncId": null
                   }
                 ],
                 "consequence": {
@@ -7473,37 +7950,40 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 68,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 132,
-                    "uuid": "beb74d50-0622-4df5-af40-a7acaa60beaa",
-                    "name": "Capivasertib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 85,
+                "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
+                "name": "Pembrolizumab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -7522,249 +8002,137 @@
     "manufacturer": "Foundation Medicine, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:07.767242Z",
+    "lastUpdated": "2024-04-06T01:04:01.518821Z",
     "fdaSubmissions": [
       {
-        "id": 37,
+        "id": 39,
         "number": "P190032",
-        "supplementNumber": "S005",
+        "supplementNumber": "S008",
         "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2022-08-15T00:00:00Z",
-        "decisionDate": "2023-05-03T00:00:00Z",
-        "description": "Approval to include a companion diagnostic indication for EGFR exon 20 insertions in patients with non-small cell lung cancer who may benefit from treatment with EXKIVITY® (mobocertinib).",
+        "dateReceived": "2022-09-26T00:00:00Z",
+        "decisionDate": "2022-12-19T00:00:00Z",
+        "description": "Approval for FoundationOne® Liquid CDx (FILCDx) label expansion to obtain companion diagnostic group labeling claim for patients with non-small cell lung cancer harboring EGFR exon 19 deletions or EGFR exon 21 L858R mutations for treatment with any one of the FDA-approved EGFR Tyrosine Kinase Inhibitors (TKI).",
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 67,
+            "id": 186,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 90,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 135,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 136,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
-                "refResidues": null,
-                "variantResidues": null,
+                "name": "L858R",
+                "alteration": "L858R",
+                "proteinChange": "L858R",
+                "start": 858,
+                "end": 858,
+                "refResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5244,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "name": "Exon 19 in-frame deletions",
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 75,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 66,
-                    "uuid": "3de4c502-6c5e-4c10-93b6-f67976c56213",
-                    "name": "Mobocertinib"
-                  }
-                ]
-              }
-            ]
-          }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
-      },
-      {
-        "id": 38,
-        "number": "P190032",
-        "supplementNumber": "",
-        "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2019-12-26T00:00:00Z",
-        "decisionDate": "2020-08-26T00:00:00Z",
-        "description": "Approval for the FoundationOne® Liquid CDx. The device is a qualitative next generation sequencing based in vitro diagnostic test that uses targeted high throughput hybridization-based capture technology to detect and report substitutions, insertions and deletions (indels) in 311 genes, including rearrangements and copy number losses only in BRCA1 and BRCA2. FoundationOne® Liquid CDx utilizes circulating cell-free DNA (cfDNA) isolated from plasma derived from anti-coagulated peripheral whole blood of cancer patients collected in FoundationOne® Liquid CDx cfDNA blood collection tubes included in the FoundationOne® Liquid CDx Blood Sample Collection Kit. The test is intended to be used as a companion diagnostic to identify patients who may benefit from treatment with the targeted therapies listed in Table 1 in accordance with the approved therapeutic product labeling. Additionally, FoundationOne® Liquid CDx is intended to provide tumor mutation profiling for substitutions and indels to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms. Table 1: Companion diagnostic indicationsTumor Type Biomarker(s) Detected TherapyNon-small cell lung cancer (NSCLC) EGFR exon 19 deletions andEGFR exon 21 L858R alteration IRESSA® (gefitinib)TAGRISSO® (osimertinib)TARCEVA® (erlotinib)Prostate cancer BRCA1, BRCA2 alterations RUBRACA® (rucaparib)A negative result from a plasma specimen does not mean that the patient’s tumor is negative for genomic findings. Patients who are negative for the mutations listed in Table 1 should be reflexed to routine biopsy and their tumor mutation status confirmed using an FDA-approved tumor tissue test, if feasible.Genomic findings other than those listed in Table 1 are not prescriptive or conclusive for labeled use of any specific therapeutic product. FoundationOne® Liquid CDx is a single-site assay performed at Foundation Medicine, Inc. in Cambridge, MA.",
-        "curated": true,
-        "genetic": true,
-        "note": null,
-        "associations": [
-          {
-            "id": 68,
-            "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 91,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
-              }
-            ],
-            "alterations": [
-              {
-                "id": 5023,
-                "type": "PROTEIN_CHANGE",
-                "name": "L858R",
-                "alteration": "L858R",
-                "proteinChange": "L858R",
-                "start": 858,
-                "end": 858,
-                "refResidues": "L",
-                "variantResidues": "R",
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
-                  "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5027,
-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
-                }
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
               }
             ],
-            "articles": null,
-            "treatments": [
+            "drugs": [
               {
-                "id": 76,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 69,
+            "id": 187,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 92,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 137,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 138,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -7773,13 +8141,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -7787,76 +8155,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 77,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 70,
+            "id": 188,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 93,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 139,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 140,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -7865,13 +8236,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -7879,105 +8250,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
-              {
-                "id": 78,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
-              }
-            ]
-          },
-          {
-            "id": 72,
-            "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 95,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
-              },
-              {
-                "id": 96,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
-              }
-            ],
-            "alterations": [
-              {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
-                    "entrezGeneId": 672,
-                    "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -7985,77 +8277,92 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 80,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
-          },
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 37,
+        "number": "P190032",
+        "supplementNumber": "S005",
+        "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2022-08-15T00:00:00Z",
+        "decisionDate": "2023-05-03T00:00:00Z",
+        "description": "Approval to include a companion diagnostic indication for EGFR exon 20 insertions in patients with non-small cell lung cancer who may benefit from treatment with EXKIVITY® (mobocertinib).",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
           {
-            "id": 73,
+            "id": 185,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 97,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 133,
+                "entity": "DRUG",
+                "rule": "67",
+                "name": null
               },
               {
-                "id": 98,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 134,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "name": "Exon 20 in-frame insertions",
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
-                    "entrezGeneId": 675,
-                    "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -8063,70 +8370,77 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 81,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 127,
-                    "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
-                    "name": "Rucaparib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 67,
+                "uuid": "3de4c502-6c5e-4c10-93b6-f67976c56213",
+                "name": "Mobocertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
       {
-        "id": 39,
+        "id": 38,
         "number": "P190032",
-        "supplementNumber": "S008",
+        "supplementNumber": "",
         "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2022-09-26T00:00:00Z",
-        "decisionDate": "2022-12-19T00:00:00Z",
-        "description": "Approval for FoundationOne® Liquid CDx (FILCDx) label expansion to obtain companion diagnostic group labeling claim for patients with non-small cell lung cancer harboring EGFR exon 19 deletions or EGFR exon 21 L858R mutations for treatment with any one of the FDA-approved EGFR Tyrosine Kinase Inhibitors (TKI).",
+        "dateReceived": "2019-12-26T00:00:00Z",
+        "decisionDate": "2020-08-26T00:00:00Z",
+        "description": "Approval for the FoundationOne® Liquid CDx. The device is a qualitative next generation sequencing based in vitro diagnostic test that uses targeted high throughput hybridization-based capture technology to detect and report substitutions, insertions and deletions (indels) in 311 genes, including rearrangements and copy number losses only in BRCA1 and BRCA2. FoundationOne® Liquid CDx utilizes circulating cell-free DNA (cfDNA) isolated from plasma derived from anti-coagulated peripheral whole blood of cancer patients collected in FoundationOne® Liquid CDx cfDNA blood collection tubes included in the FoundationOne® Liquid CDx Blood Sample Collection Kit. The test is intended to be used as a companion diagnostic to identify patients who may benefit from treatment with the targeted therapies listed in Table 1 in accordance with the approved therapeutic product labeling. Additionally, FoundationOne® Liquid CDx is intended to provide tumor mutation profiling for substitutions and indels to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms. Table 1: Companion diagnostic indicationsTumor Type Biomarker(s) Detected TherapyNon-small cell lung cancer (NSCLC) EGFR exon 19 deletions andEGFR exon 21 L858R alteration IRESSA® (gefitinib)TAGRISSO® (osimertinib)TARCEVA® (erlotinib)Prostate cancer BRCA1, BRCA2 alterations RUBRACA® (rucaparib)A negative result from a plasma specimen does not mean that the patient’s tumor is negative for genomic findings. Patients who are negative for the mutations listed in Table 1 should be reflexed to routine biopsy and their tumor mutation status confirmed using an FDA-approved tumor tissue test, if feasible.Genomic findings other than those listed in Table 1 are not prescriptive or conclusive for labeled use of any specific therapeutic product. FoundationOne® Liquid CDx is a single-site assay performed at Foundation Medicine, Inc. in Cambridge, MA.",
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 68,
+            "id": 186,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 91,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 135,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 136,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -8135,13 +8449,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -8149,76 +8463,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 76,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 69,
+            "id": 187,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 92,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 137,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 138,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -8227,13 +8544,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -8241,76 +8558,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 77,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 70,
+            "id": 188,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 93,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 139,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 140,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -8319,13 +8639,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -8333,60 +8653,223 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 78,
-                "name": null,
-                "drugs": [
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 190,
+            "name": null,
+            "rules": [
+              {
+                "id": 143,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
+              },
+              {
+                "id": 144,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 2054,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 191,
+            "name": null,
+            "rules": [
+              {
+                "id": 145,
+                "entity": "DRUG",
+                "rule": "128",
+                "name": null
+              },
+              {
+                "id": 146,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 2677,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
+                    "id": 32458,
+                    "entrezGeneId": 675,
+                    "hugoSymbol": "BRCA2",
+                    "hgncId": "1101"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 128,
+                "uuid": "75ceadf8-0171-4f62-97ff-b008b15effb3",
+                "name": "Rucaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -8402,29 +8885,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 71,
+            "id": 189,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 94,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 141,
+                "entity": "DRUG",
+                "rule": "118+120",
+                "name": null
+              },
+              {
+                "id": 142,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -8433,13 +8915,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -8447,37 +8929,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 79,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
-                  {
-                    "id": 119,
-                    "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
-                    "name": "Binimetinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 120,
+                "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
+                "name": "Binimetinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -8493,29 +8984,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 74,
+            "id": 192,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 99,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 147,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 148,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15858,
+                "id": 15961,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8524,62 +9014,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 6685,
+                    "id": 6704,
                     "entrezGeneId": 6098,
                     "hugoSymbol": "ROS1",
-                    "hgncId": "10261",
-                    "evidences": null
+                    "hgncId": "10261"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 82,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 75,
+            "id": 193,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 100,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 149,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 150,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12991,
+                "id": 13094,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8588,62 +9082,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20529,
+                    "id": 20523,
                     "entrezGeneId": 4914,
                     "hugoSymbol": "NTRK1",
-                    "hgncId": "8031",
-                    "evidences": null
+                    "hgncId": "8031"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 83,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 76,
+            "id": 194,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 101,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 151,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 152,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13050,
+                "id": 13153,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8652,62 +9150,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20530,
+                    "id": 20524,
                     "entrezGeneId": 4915,
                     "hugoSymbol": "NTRK2",
-                    "hgncId": "8032",
-                    "evidences": null
+                    "hgncId": "8032"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 84,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 77,
+            "id": 195,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 102,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 3,
-                  "code": "ALL_SOLID_TUMORS",
-                  "color": "MIXED",
-                  "level": -1,
-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
-                }
+                "id": 153,
+                "entity": "DRUG",
+                "rule": "134",
+                "name": null
+              },
+              {
+                "id": 154,
+                "entity": "CANCER_TYPE",
+                "rule": "3",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13070,
+                "id": 13173,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8716,46 +9218,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39108,
+                    "id": 38985,
                     "entrezGeneId": 4916,
                     "hugoSymbol": "NTRK3",
-                    "hgncId": "8033",
-                    "evidences": null
+                    "hgncId": "8033"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 85,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 133,
-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
-                  }
-                ]
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 134,
+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
+                "name": "Entrectinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -8771,29 +9281,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 78,
+            "id": 196,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 103,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 155,
+                "entity": "DRUG",
+                "rule": "99",
+                "name": null
+              },
+              {
+                "id": 156,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
+                "id": 662,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8802,77 +9311,81 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
+                    "id": 21829,
                     "entrezGeneId": 238,
                     "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 86,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 98,
-                    "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
-                    "name": "Alectinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 99,
+                "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
+                "name": "Alectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 79,
+            "id": 197,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 104,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 157,
+                "entity": "DRUG",
+                "rule": "84+33",
+                "name": null
+              },
+              {
+                "id": 158,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13431,
+                "id": 13532,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
+                "variantResidues": "D",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -8880,12 +9393,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13426,
+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -8894,13 +9406,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -8908,12 +9420,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13427,
+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -8922,13 +9433,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -8936,27 +9447,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13428,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545A",
-                "alteration": "E545A",
-                "proteinChange": "E545A",
-                "start": 545,
-                "end": 545,
-                "refResidues": "E",
-                "variantResidues": "A",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
+                "start": 1047,
+                "end": 1047,
+                "refResidues": "H",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -8964,27 +9474,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13429,
+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
-                "start": 545,
-                "end": 545,
+                "name": "E545A",
+                "alteration": "E545A",
+                "proteinChange": "E545A",
+                "start": 545,
+                "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "A",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -8992,12 +9501,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545G",
                 "alteration": "E545G",
@@ -9006,13 +9514,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9020,27 +9528,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546E",
-                "alteration": "Q546E",
-                "proteinChange": "Q546E",
-                "start": 546,
-                "end": 546,
-                "refResidues": "Q",
-                "variantResidues": "E",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
+                "start": 545,
+                "end": 545,
+                "refResidues": "E",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9048,27 +9555,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546R",
-                "alteration": "Q546R",
-                "proteinChange": "Q546R",
+                "name": "Q546E",
+                "alteration": "Q546E",
+                "proteinChange": "Q546E",
                 "start": 546,
                 "end": 546,
                 "refResidues": "Q",
-                "variantResidues": "R",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9076,27 +9582,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047R",
+                "alteration": "H1047R",
+                "proteinChange": "H1047R",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9104,27 +9609,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047R",
-                "alteration": "H1047R",
-                "proteinChange": "H1047R",
-                "start": 1047,
-                "end": 1047,
-                "refResidues": "H",
+                "name": "Q546R",
+                "alteration": "Q546R",
+                "proteinChange": "Q546R",
+                "start": 546,
+                "end": 546,
+                "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9132,27 +9636,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -9160,362 +9663,686 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 87,
-                "name": null,
-                "drugs": [
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 198,
+            "name": null,
+            "rules": [
+              {
+                "id": 159,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
+              },
+              {
+                "id": 160,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 2054,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 199,
+            "name": null,
+            "rules": [
+              {
+                "id": 161,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
+              },
+              {
+                "id": 162,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 2677,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
+                    "id": 32458,
+                    "entrezGeneId": 675,
+                    "hugoSymbol": "BRCA2",
+                    "hgncId": "1101"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 80,
+            "id": 200,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 105,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
+                "id": 163,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
+              },
+              {
+                "id": 164,
+                "entity": "CANCER_TYPE",
+                "rule": "935,987",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 988,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 23657,
+                    "entrezGeneId": 472,
+                    "hugoSymbol": "ATM",
+                    "hgncId": "795"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 935,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer, NOS",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
               },
               {
-                "id": 106,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 43,
+        "number": "P190032",
+        "supplementNumber": "S010",
+        "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2022-11-22T00:00:00Z",
+        "decisionDate": "2023-06-08T00:00:00Z",
+        "description": "Approval for the FoundationOne Liquid CDx (F1 Liquid CDx). The device expands the indications for use to include a companion diagnostic indication for the detection of BRAF V600E alteration in patients with metastatic colorectal cancer (CRC) who may benefit from treatment with BRAFTOVI® (encorafenib) in combination with cetuximab. ",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 201,
+            "name": null,
+            "rules": [
+              {
+                "id": 165,
+                "entity": "DRUG",
+                "rule": "118+124",
+                "name": null
+              },
+              {
+                "id": 166,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 1491,
+                "type": "PROTEIN_CHANGE",
+                "name": "V600E",
+                "alteration": "V600E",
+                "proteinChange": "V600E",
+                "start": 600,
+                "end": 600,
+                "refResidues": "V",
+                "variantResidues": "E",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 41135,
+                    "entrezGeneId": 673,
+                    "hugoSymbol": "BRAF",
+                    "hgncId": "1097"
+                  }
+                ],
+                "consequence": {
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
+                  "isGenerallyTruncating": false,
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 99,
+        "number": "P190032",
+        "supplementNumber": "S001",
+        "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2020-08-27T04:00:00Z",
+        "decisionDate": "2021-07-14T04:00:00Z",
+        "description": "Approval to include a companion diagnostic indication for detection of MET single nucleotide variants (SNVs) and indels that lead to MET exon 14 skipping in non-small cell lung cancer patients who may benefit from treatment with TABRECTA (capmatinib)",
+        "curated": false,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 269,
+            "name": null,
+            "rules": [],
             "alterations": [
               {
-                "id": 1951,
+                "id": 11231,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010splice",
+                "alteration": "963_1010splice",
+                "proteinChange": "963_1010splice",
+                "start": 963,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 27,
+                  "term": "SPLICE_REGION_VARIANT",
+                  "name": "Splice Region Variant",
+                  "isGenerallyTruncating": true,
+                  "description": "A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron"
+                }
+              },
+              {
+                "id": 11238,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010del",
+                "alteration": "963_1010del",
+                "proteinChange": "963_1010del",
+                "start": 963,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 11,
+                  "term": "INFRAME_DELETION",
+                  "name": "Inframe Deletion",
+                  "isGenerallyTruncating": false,
+                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence"
+                }
+              },
+              {
+                "id": 11240,
                 "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
-                "start": null,
-                "end": null,
-                "refResidues": null,
-                "variantResidues": null,
+                "name": "D1010",
+                "alteration": "D1010",
+                "proteinChange": "D1010",
+                "start": 1010,
+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
-                    "entrezGeneId": 672,
-                    "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 88,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 82,
+                "uuid": "8ddbbd88-3730-4ea2-8cba-b5038d250fd1",
+                "name": "Capmatinib",
+                "fdaDrugs": null
               }
             ]
-          },
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      },
+      {
+        "id": 100,
+        "number": "P190032",
+        "supplementNumber": "S014",
+        "deviceName": "FoundationOne Liquid CDx (F1LCDx)",
+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
+        "dateReceived": "2023-09-27T04:00:00Z",
+        "decisionDate": "2024-06-27T04:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne Liquid CDx (F1LCDx) to include a companion diagnostic indication for identifying patients with Prostate Cancer harboring a BRCA1 or BRCA2 alteration who may benefit from treatment with AKEEGA® (niraparib + abiraterone acetate). ",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
           {
-            "id": 81,
+            "id": 275,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 107,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 108,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 291,
+                "entity": "DRUG",
+                "rule": "38+40+27",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 89,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 27,
+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
+                "fdaDrugs": null
+              },
+              {
+                "id": 38,
+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 82,
+            "id": 276,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 109,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 935,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer, NOS",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 110,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 987,
-                  "code": null,
-                  "color": "Cyan",
-                  "level": 0,
-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
+                "id": 292,
+                "entity": "DRUG",
+                "rule": "38+40+27",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 885,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23673,
-                    "entrezGeneId": 472,
-                    "hugoSymbol": "ATM",
-                    "hgncId": "795",
-                    "evidences": null
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
-              {
-                "id": 90,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
-              }
-            ]
-          }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
-      },
-      {
-        "id": 43,
-        "number": "P190032",
-        "supplementNumber": "S010",
-        "deviceName": "FoundationOne Liquid CDx (F1 Liquid CDx)",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2022-11-22T00:00:00Z",
-        "decisionDate": "2023-06-08T00:00:00Z",
-        "description": "Approval for the FoundationOne Liquid CDx (F1 Liquid CDx). The device expands the indications for use to include a companion diagnostic indication for the detection of BRAF V600E alteration in patients with metastatic colorectal cancer (CRC) who may benefit from treatment with BRAFTOVI® (encorafenib) in combination with cetuximab. ",
-        "curated": true,
-        "genetic": true,
-        "note": null,
-        "associations": [
-          {
-            "id": 83,
-            "name": null,
-            "associationCancerTypes": [
+            "cancerTypes": [
               {
-                "id": 111,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
               }
             ],
-            "alterations": [
+            "drugs": [
               {
-                "id": 1388,
-                "type": "PROTEIN_CHANGE",
-                "name": "V600E",
-                "alteration": "V600E",
-                "proteinChange": "V600E",
-                "start": 600,
-                "end": 600,
-                "refResidues": "V",
-                "variantResidues": "E",
-                "genes": [
-                  {
-                    "id": 41259,
-                    "entrezGeneId": 673,
-                    "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
-                  "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
-                }
-              }
-            ],
-            "articles": null,
-            "treatments": [
+                "id": 27,
+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
+                "fdaDrugs": null
+              },
               {
-                "id": 91,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 38,
+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -9534,7 +10361,7 @@
     "manufacturer": "Guardant Health, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:10.899676Z",
+    "lastUpdated": "2024-04-06T01:04:04.474379Z",
     "fdaSubmissions": [
       {
         "id": 44,
@@ -9548,29 +10375,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 84,
+            "id": 202,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 112,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 167,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 168,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -9579,13 +10405,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -9593,12 +10419,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -9607,13 +10432,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -9621,60 +10446,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 92,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -9690,105 +10522,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 85,
+            "id": 203,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 113,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 169,
+                "entity": "DRUG",
+                "rule": "54",
+                "name": null
+              },
+              {
+                "id": 170,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5244,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 93,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 53,
-                    "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
-                    "name": "Amivantamab"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 54,
+                "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
+                "name": "Amivantamab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -9804,29 +10615,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 86,
+            "id": 204,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 114,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 171,
+                "entity": "DRUG",
+                "rule": "17",
+                "name": null
+              },
+              {
+                "id": 172,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -9835,13 +10645,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -9849,32 +10659,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 94,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 17,
-                    "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
-                    "name": "Sotorasib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 17,
+                "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
+                "name": "Sotorasib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -9890,77 +10708,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 87,
+            "id": 205,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 115,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 173,
+                "entity": "DRUG",
+                "rule": "86",
+                "name": null
+              },
+              {
+                "id": 174,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6078,
-                "type": "PROTEIN_CHANGE",
+                "id": 6181,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 95,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 85,
-                    "uuid": "37dd10c7-69c0-4d63-a171-8cb2570c1a54",
-                    "name": "Trastuzumab Deruxtecan"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 86,
+                "uuid": "37dd10c7-69c0-4d63-a171-8cb2570c1a54",
+                "name": "Trastuzumab Deruxtecan",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -9976,29 +10801,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 88,
+            "id": 206,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 116,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 175,
+                "entity": "DRUG",
+                "rule": "58",
+                "name": null
+              },
+              {
+                "id": 176,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 7547,
+                "id": 7650,
                 "type": "PROTEIN_CHANGE",
                 "name": "S463P",
                 "alteration": "S463P",
@@ -10007,13 +10831,13 @@
                 "end": 463,
                 "refResidues": "S",
                 "variantResidues": "P",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10021,12 +10845,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7550,
+                "id": 7653,
                 "type": "PROTEIN_CHANGE",
                 "name": "L469V",
                 "alteration": "L469V",
@@ -10035,13 +10858,13 @@
                 "end": 469,
                 "refResidues": "L",
                 "variantResidues": "V",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10049,12 +10872,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7561,
+                "id": 7664,
                 "type": "PROTEIN_CHANGE",
                 "name": "D538",
                 "alteration": "D538",
@@ -10063,13 +10885,13 @@
                 "end": 538,
                 "refResidues": "D",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10077,12 +10899,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 7562,
+                "id": 7665,
                 "type": "PROTEIN_CHANGE",
                 "name": "E380",
                 "alteration": "E380",
@@ -10091,13 +10912,13 @@
                 "end": 380,
                 "refResidues": "E",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10105,12 +10926,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 7563,
+                "id": 7666,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y537",
                 "alteration": "Y537",
@@ -10119,13 +10939,13 @@
                 "end": 537,
                 "refResidues": "Y",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10133,12 +10953,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 7564,
+                "id": 7667,
                 "type": "PROTEIN_CHANGE",
                 "name": "L536",
                 "alteration": "L536",
@@ -10147,13 +10966,13 @@
                 "end": 536,
                 "refResidues": "L",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24657,
+                    "id": 24628,
                     "entrezGeneId": 2099,
                     "hugoSymbol": "ESR1",
-                    "hgncId": "3467",
-                    "evidences": null
+                    "hgncId": "3467"
                   }
                 ],
                 "consequence": {
@@ -10161,32 +10980,40 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               }
             ],
-            "articles": null,
-            "treatments": [
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
               {
-                "id": 96,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 57,
-                    "uuid": "011f81cc-06a0-45d5-b2c1-22052afa7cd6",
-                    "name": "Elacestrant"
-                  }
-                ]
+                "id": 58,
+                "uuid": "011f81cc-06a0-45d5-b2c1-22052afa7cd6",
+                "name": "Elacestrant",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -10205,7 +11032,7 @@
     "manufacturer": "Dako Denmark A/S",
     "indicationDetails": null,
     "platformType": "CISH",
-    "lastUpdated": "2024-01-11T17:01:11.326058Z",
+    "lastUpdated": "2024-04-06T01:04:04.903740Z",
     "fdaSubmissions": [
       {
         "id": 49,
@@ -10219,29 +11046,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 89,
+            "id": 207,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 117,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 177,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 178,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10250,62 +11076,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 97,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 98,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -10324,7 +11148,7 @@
     "manufacturer": "Dako Denmark A/S",
     "indicationDetails": null,
     "platformType": "FISH",
-    "lastUpdated": "2024-01-11T17:01:13.364216Z",
+    "lastUpdated": "2024-04-06T01:04:06.743663Z",
     "fdaSubmissions": [
       {
         "id": 50,
@@ -10338,29 +11162,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 90,
+            "id": 208,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 118,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 179,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 180,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10369,62 +11192,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 99,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 100,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -10440,29 +11261,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 91,
+            "id": 209,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 119,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 967,
-                  "code": null,
-                  "color": "LightSkyBlue",
-                  "level": 0,
-                  "mainType": "Esophagogastric Cancer",
-                  "subtype": null,
-                  "tissue": "Esophagus/Stomach",
-                  "tumorForm": "SOLID"
-                }
+                "id": 181,
+                "entity": "DRUG",
+                "rule": "85+39+104,39+104",
+                "name": null
+              },
+              {
+                "id": 182,
+                "entity": "CANCER_TYPE",
+                "rule": "967",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10471,72 +11291,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 101,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 84,
-                    "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
-                    "name": "Pembrolizumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 967,
+                "code": null,
+                "color": "LightSkyBlue",
+                "level": 0,
+                "mainType": "Esophagogastric Cancer",
+                "subtype": null,
+                "tissue": "Esophagus/Stomach",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 102,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 85,
+                "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
+                "name": "Pembrolizumab",
+                "fdaDrugs": null
+              },
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -10552,29 +11366,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 92,
+            "id": 210,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 120,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 183,
+                "entity": "DRUG",
+                "rule": "39+149+104",
+                "name": null
+              },
+              {
+                "id": 184,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10583,56 +11396,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 103,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 148,
-                    "uuid": "b89a5c78-1828-4adf-a9fa-937f99410c1d",
-                    "name": "Pertuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
+              },
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
+              },
+              {
+                "id": 149,
+                "uuid": "b89a5c78-1828-4adf-a9fa-937f99410c1d",
+                "name": "Pertuzumab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -10648,29 +11471,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 93,
+            "id": 211,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 121,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 185,
+                "entity": "DRUG",
+                "rule": "7",
+                "name": null
+              },
+              {
+                "id": 186,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10679,46 +11501,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 104,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 7,
-                    "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
-                    "name": "Ado-Trastuzumab Emtansine"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 7,
+                "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
+                "name": "Ado-Trastuzumab Emtansine",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -10737,7 +11567,7 @@
     "manufacturer": "Ventana Medical Systems, Inc.",
     "indicationDetails": null,
     "platformType": "FISH",
-    "lastUpdated": "2024-01-11T17:01:13.729155Z",
+    "lastUpdated": "2024-04-06T01:04:07.075884Z",
     "fdaSubmissions": [
       {
         "id": 54,
@@ -10751,29 +11581,28 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 94,
+            "id": 212,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 122,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 187,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 188,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10782,62 +11611,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 105,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 106,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -10856,7 +11683,7 @@
     "manufacturer": "Ventana Medical Systems, Inc.",
     "indicationDetails": null,
     "platformType": "CISH",
-    "lastUpdated": "2024-01-11T17:01:14.685653Z",
+    "lastUpdated": "2024-04-06T01:04:08.155671Z",
     "fdaSubmissions": [
       {
         "id": 55,
@@ -10870,29 +11697,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 95,
+            "id": 213,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 123,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 189,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 190,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -10901,62 +11727,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 107,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 108,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -10972,29 +11796,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 96,
+            "id": 214,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 124,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 191,
+                "entity": "DRUG",
+                "rule": "7",
+                "name": null
+              },
+              {
+                "id": 192,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -11003,46 +11826,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 109,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 7,
-                    "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
-                    "name": "Ado-Trastuzumab Emtansine"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 7,
+                "uuid": "598e7b9f-976d-46bc-aea7-42f1005db988",
+                "name": "Ado-Trastuzumab Emtansine",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -11061,7 +11892,7 @@
     "manufacturer": "Biogenex Laboratories, Inc.",
     "indicationDetails": null,
     "platformType": "IHC",
-    "lastUpdated": "2024-01-11T17:01:15.445914Z",
+    "lastUpdated": "2024-04-06T01:04:08.773837Z",
     "fdaSubmissions": [
       {
         "id": 57,
@@ -11075,29 +11906,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 97,
+            "id": 215,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 125,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 193,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 194,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -11106,62 +11936,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 110,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 111,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -11180,7 +12008,7 @@
     "manufacturer": "ARUP Laboratories, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:15.906343Z",
+    "lastUpdated": "2024-04-06T01:04:09.200329Z",
     "fdaSubmissions": [
       {
         "id": 58,
@@ -11194,29 +12022,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 98,
+            "id": 216,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 126,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 394,
-                  "code": "MCD",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Mastocytosis",
-                  "subtype": "Mastocytosis",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 195,
+                "entity": "DRUG",
+                "rule": "74",
+                "name": null
+              },
+              {
+                "id": 196,
+                "entity": "CANCER_TYPE",
+                "rule": "394",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9828,
+                "id": 9931,
                 "type": "PROTEIN_CHANGE",
                 "name": "D816",
                 "alteration": "D816",
@@ -11225,13 +12052,13 @@
                 "end": 816,
                 "refResidues": "D",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 19080,
+                    "id": 19078,
                     "entrezGeneId": 3815,
                     "hugoSymbol": "KIT",
-                    "hgncId": "6342",
-                    "evidences": null
+                    "hgncId": "6342"
                   }
                 ],
                 "consequence": {
@@ -11239,32 +12066,40 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 112,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 73,
-                    "uuid": "3d49e386-0cc4-401e-9acd-d2d33b2923a3",
-                    "name": "Avapritinib"
-                  }
-                ]
+                "id": 394,
+                "code": "MCD",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Mastocytosis",
+                "subtype": "Mastocytosis",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 74,
+                "uuid": "3d49e386-0cc4-401e-9acd-d2d33b2923a3",
+                "name": "Avapritinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 3,
-          "type": "HDE",
+          "type": "DEVICE_HDE",
           "name": "Humanitarian Device Exemption",
           "shortName": "HDE",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Searchable listing of Humanitarian Device Exemption (HDE) Class III medical devices."
         }
       }
@@ -11283,7 +12118,7 @@
     "manufacturer": "Invivoscribe Technologies, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:17.183714Z",
+    "lastUpdated": "2024-04-06T01:04:10.741932Z",
     "fdaSubmissions": [
       {
         "id": 59,
@@ -11297,57 +12132,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 99,
+            "id": 217,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 127,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 197,
+                "entity": "DRUG",
+                "rule": "132+148",
+                "name": null
+              },
+              {
+                "id": 198,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8705,
-                "type": "PROTEIN_CHANGE",
-                "name": "Internal tandem duplication",
-                "alteration": "572_630ins",
-                "proteinChange": "572_630ins",
-                "start": 572,
-                "end": 630,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 20903,
-                    "entrezGeneId": 2322,
-                    "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 8706,
+                "id": 8809,
                 "type": "PROTEIN_CHANGE",
                 "name": "D835",
                 "alteration": "D835",
@@ -11356,13 +12162,13 @@
                 "end": 835,
                 "refResidues": "D",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11370,12 +12176,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 8707,
+                "id": 8810,
                 "type": "PROTEIN_CHANGE",
                 "name": "I836",
                 "alteration": "I836",
@@ -11384,13 +12189,13 @@
                 "end": 836,
                 "refResidues": "I",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11398,37 +12203,73 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
+                }
+              },
+              {
+                "id": 22642,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Internal Tandem Duplication",
+                "alteration": "Internal Tandem Duplication",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20899,
+                    "entrezGeneId": 2322,
+                    "hugoSymbol": "FLT3",
+                    "hgncId": "3765"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 113,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 131,
-                    "uuid": "b4012b4d-f7a5-49d9-9101-a4e1de203e9e",
-                    "name": "Midostaurin"
-                  },
-                  {
-                    "id": 147,
-                    "uuid": "faef6994-b7f8-4845-9f10-8eab19d7cb86",
-                    "name": "High Dose Chemotherapy"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 132,
+                "uuid": "b4012b4d-f7a5-49d9-9101-a4e1de203e9e",
+                "name": "Midostaurin",
+                "fdaDrugs": null
+              },
+              {
+                "id": 148,
+                "uuid": "faef6994-b7f8-4845-9f10-8eab19d7cb86",
+                "name": "High Dose Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -11444,57 +12285,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 100,
+            "id": 218,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 128,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 199,
+                "entity": "DRUG",
+                "rule": "69",
+                "name": null
+              },
+              {
+                "id": 200,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8705,
-                "type": "PROTEIN_CHANGE",
-                "name": "Internal tandem duplication",
-                "alteration": "572_630ins",
-                "proteinChange": "572_630ins",
-                "start": 572,
-                "end": 630,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 20903,
-                    "entrezGeneId": 2322,
-                    "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 8706,
+                "id": 8809,
                 "type": "PROTEIN_CHANGE",
                 "name": "D835",
                 "alteration": "D835",
@@ -11503,13 +12315,13 @@
                 "end": 835,
                 "refResidues": "D",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11517,12 +12329,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 8707,
+                "id": 8810,
                 "type": "PROTEIN_CHANGE",
                 "name": "I836",
                 "alteration": "I836",
@@ -11531,13 +12342,13 @@
                 "end": 836,
                 "refResidues": "I",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11545,32 +12356,67 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
+                }
+              },
+              {
+                "id": 22642,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Internal Tandem Duplication",
+                "alteration": "Internal Tandem Duplication",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20899,
+                    "entrezGeneId": 2322,
+                    "hugoSymbol": "FLT3",
+                    "hgncId": "3765"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 114,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 68,
-                    "uuid": "562b1317-49f3-471d-82fe-211cf5e5e290",
-                    "name": "Gilteritinib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 69,
+                "uuid": "562b1317-49f3-471d-82fe-211cf5e5e290",
+                "name": "Gilteritinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -11586,57 +12432,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 101,
+            "id": 219,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 129,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 201,
+                "entity": "DRUG",
+                "rule": "116",
+                "name": null
+              },
+              {
+                "id": 202,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8705,
-                "type": "PROTEIN_CHANGE",
-                "name": "Internal tandem duplication",
-                "alteration": "572_630ins",
-                "proteinChange": "572_630ins",
-                "start": 572,
-                "end": 630,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 20903,
-                    "entrezGeneId": 2322,
-                    "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 8706,
+                "id": 8809,
                 "type": "PROTEIN_CHANGE",
                 "name": "D835",
                 "alteration": "D835",
@@ -11645,13 +12462,13 @@
                 "end": 835,
                 "refResidues": "D",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11659,12 +12476,11 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               },
               {
-                "id": 8707,
+                "id": 8810,
                 "type": "PROTEIN_CHANGE",
                 "name": "I836",
                 "alteration": "I836",
@@ -11673,13 +12489,13 @@
                 "end": 836,
                 "refResidues": "I",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20903,
+                    "id": 20899,
                     "entrezGeneId": 2322,
                     "hugoSymbol": "FLT3",
-                    "hgncId": "3765",
-                    "evidences": null
+                    "hgncId": "3765"
                   }
                 ],
                 "consequence": {
@@ -11687,32 +12503,67 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
+                }
+              },
+              {
+                "id": 22642,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Internal Tandem Duplication",
+                "alteration": "Internal Tandem Duplication",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20899,
+                    "entrezGeneId": 2322,
+                    "hugoSymbol": "FLT3",
+                    "hgncId": "3765"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 115,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 115,
-                    "uuid": "58ca4d1c-3ea7-4dec-a0b6-036021d0a859",
-                    "name": "Quizartinib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 116,
+                "uuid": "58ca4d1c-3ea7-4dec-a0b6-036021d0a859",
+                "name": "Quizartinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -11736,7 +12587,7 @@
     "manufacturer": "MolecularMD Corporation",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:17.504051Z",
+    "lastUpdated": "2024-04-06T01:04:11.329604Z",
     "fdaSubmissions": [
       {
         "id": 62,
@@ -11750,29 +12601,28 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 102,
+            "id": 220,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 130,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 685,
-                  "code": "CML",
-                  "color": "LightSalmon",
-                  "level": 4,
-                  "mainType": "Myeloproliferative Neoplasms",
-                  "subtype": "Chronic Myelogenous Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 203,
+                "entity": "DRUG",
+                "rule": "111",
+                "name": null
+              },
+              {
+                "id": 204,
+                "entity": "CANCER_TYPE",
+                "rule": "685",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 2,
+                "id": 105,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "BCR-ABL1 Fusion",
                 "alteration": "BCR-ABL1 Fusion",
@@ -11781,13 +12631,19 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 27789,
+                    "id": 13983,
+                    "entrezGeneId": 613,
+                    "hugoSymbol": "BCR",
+                    "hgncId": "1014"
+                  },
+                  {
+                    "id": 27752,
                     "entrezGeneId": 25,
                     "hugoSymbol": "ABL1",
-                    "hgncId": "76",
-                    "evidences": null
+                    "hgncId": "76"
                   }
                 ],
                 "consequence": {
@@ -11795,32 +12651,40 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 116,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 110,
-                    "uuid": "0f991d49-4cf2-4975-b52f-d7d037aa7f11",
-                    "name": "Nilotinib"
-                  }
-                ]
+                "id": 685,
+                "code": "CML",
+                "color": "LightSalmon",
+                "level": 4,
+                "mainType": "Myeloproliferative Neoplasms",
+                "subtype": "Chronic Myelogenous Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 111,
+                "uuid": "0f991d49-4cf2-4975-b52f-d7d037aa7f11",
+                "name": "Nilotinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 4,
-          "type": "PMN",
+          "type": "DEVICE_PMN",
           "name": "Premarket Notifications (510(k)s)",
           "shortName": "510(k)",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Medical device manufacturers are required to submit a premarket notification or 510(k) if they intend to introduce a device into commercial distribution for the first time or reintroduce a device that will be significantly changed or modified to the extent that its safety or effectiveness could be affected. This database of releasable 510(k)s can be searched by 510(k) number, applicant, device name or FDA product code.  Summaries of safety and effectiveness information is available via the web interface for more recent records. The database is updated once a week."
         }
       }
@@ -11839,7 +12703,7 @@
     "manufacturer": "Myriad Genetic Laboratories, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:17.933425Z",
+    "lastUpdated": "2024-04-06T01:04:11.752934Z",
     "fdaSubmissions": [
       {
         "id": 63,
@@ -11853,133 +12717,131 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 103,
+            "id": 221,
             "name": null,
-            "associationCancerTypes": [
-              {
-                "id": 131,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 910,
-                  "code": null,
-                  "color": "LightBlue",
-                  "level": 0,
-                  "mainType": "Ovarian Cancer",
-                  "subtype": null,
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
-              },
+            "rules": [
               {
-                "id": 132,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 28,
-                  "code": "OVARY",
-                  "color": "LightBlue",
-                  "level": 1,
-                  "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
-                  "subtype": "Ovary/Fallopian Tube",
-                  "tissue": "Ovary/Fallopian Tube",
-                  "tumorForm": "SOLID"
-                }
+                "id": 205,
+                "entity": "DRUG",
+                "rule": "146",
+                "name": null
               },
               {
-                "id": 133,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 270,
-                  "code": "PSEC",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Peritoneal Cancer, NOS",
-                  "subtype": "Peritoneal Serous Carcinoma",
-                  "tissue": "Peritoneum",
-                  "tumorForm": "SOLID"
-                }
+                "id": 206,
+                "entity": "CANCER_TYPE",
+                "rule": "910,28,270",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1951,
-                "type": "PROTEIN_CHANGE",
+                "id": 2054,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41258,
+                    "id": 41134,
                     "entrezGeneId": 672,
                     "hugoSymbol": "BRCA1",
-                    "hgncId": "1100",
-                    "evidences": null
+                    "hgncId": "1100"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               },
               {
-                "id": 2574,
-                "type": "PROTEIN_CHANGE",
+                "id": 2677,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 32518,
+                    "id": 32458,
                     "entrezGeneId": 675,
                     "hugoSymbol": "BRCA2",
-                    "hgncId": "1101",
-                    "evidences": null
+                    "hgncId": "1101"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 117,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 145,
-                    "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
-                    "name": "Olaparib"
-                  }
-                ]
+                "id": 28,
+                "code": "OVARY",
+                "color": "LightBlue",
+                "level": 1,
+                "mainType": "Ovarian/Fallopian Tube Cancer, NOS",
+                "subtype": "Ovary/Fallopian Tube",
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 270,
+                "code": "PSEC",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Peritoneal Cancer, NOS",
+                "subtype": "Peritoneal Serous Carcinoma",
+                "tissue": "Peritoneum",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 910,
+                "code": null,
+                "color": "LightBlue",
+                "level": 0,
+                "mainType": "Ovarian Cancer",
+                "subtype": null,
+                "tissue": "Ovary/Fallopian Tube",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 146,
+                "uuid": "578af76a-2e8a-463a-b7bd-0494c91ad2a1",
+                "name": "Olaparib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -11998,7 +12860,7 @@
     "manufacturer": "Pillar Biosciences, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:18.780352Z",
+    "lastUpdated": "2024-04-06T01:04:12.270823Z",
     "fdaSubmissions": [
       {
         "id": 64,
@@ -12012,29 +12874,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 104,
+            "id": 222,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 134,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 207,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 208,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -12043,13 +12904,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -12057,64 +12918,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 118,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               },
               {
-                "id": 119,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 105,
+            "id": 223,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 135,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 209,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 210,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -12123,13 +12978,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -12137,48 +12992,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 120,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 121,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -12197,7 +13050,7 @@
     "manufacturer": "Life Technologies Corporation",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:23.868012Z",
+    "lastUpdated": "2024-04-06T01:04:16.096444Z",
     "fdaSubmissions": [
       {
         "id": 65,
@@ -12211,29 +13064,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 106,
+            "id": 224,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 136,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 211,
+                "entity": "DRUG",
+                "rule": "15+123",
+                "name": null
+              },
+              {
+                "id": 212,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -12242,13 +13094,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -12256,53 +13108,58 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 122,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 15,
-                    "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
-                    "name": "Dabrafenib"
-                  },
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 15,
+                "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
+                "name": "Dabrafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 107,
+            "id": 225,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 137,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 213,
+                "entity": "DRUG",
+                "rule": "3",
+                "name": null
+              },
+              {
+                "id": 214,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15858,
+                "id": 15961,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -12311,62 +13168,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 6685,
+                    "id": 6704,
                     "entrezGeneId": 6098,
                     "hugoSymbol": "ROS1",
-                    "hgncId": "10261",
-                    "evidences": null
+                    "hgncId": "10261"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 123,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 3,
-                    "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
-                    "name": "Crizotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 3,
+                "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
+                "name": "Crizotinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 108,
+            "id": 226,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 138,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 215,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 216,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -12375,13 +13236,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -12389,60 +13250,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 124,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12458,29 +13326,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 109,
+            "id": 227,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 139,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 217,
+                "entity": "DRUG",
+                "rule": "37",
+                "name": null
+              },
+              {
+                "id": 218,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15637,
+                "id": 15740,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -12489,46 +13356,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 5106,
+                    "id": 5121,
                     "entrezGeneId": 5979,
                     "hugoSymbol": "RET",
-                    "hgncId": "9967",
-                    "evidences": null
+                    "hgncId": "9967"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
-            "articles": null,
-            "treatments": [
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
               {
-                "id": 125,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 36,
-                    "uuid": "7f9be086-3520-4c28-a414-8d4f3682f920",
-                    "name": "Pralsetinib"
-                  }
-                ]
+                "id": 37,
+                "uuid": "7f9be086-3520-4c28-a414-8d4f3682f920",
+                "name": "Pralsetinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12544,105 +13419,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 110,
+            "id": 228,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 140,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 219,
+                "entity": "DRUG",
+                "rule": "54",
+                "name": null
+              },
+              {
+                "id": 220,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5244,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 126,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 53,
-                    "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
-                    "name": "Amivantamab"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 54,
+                "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
+                "name": "Amivantamab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12658,43 +13512,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 111,
+            "id": 229,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 141,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 400,
-                  "code": "IHCH",
-                  "color": "Green",
-                  "level": 3,
-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Intrahepatic Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 221,
+                "entity": "DRUG",
+                "rule": "30",
+                "name": null
               },
               {
-                "id": 142,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 115,
-                  "code": "CHOL",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 222,
+                "entity": "CANCER_TYPE",
+                "rule": "400,115",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9277,
+                "id": 9380,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132",
                 "alteration": "R132",
@@ -12703,13 +13542,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -12717,32 +13556,50 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 127,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 29,
-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 115,
+                "code": "CHOL",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Hepatobiliary Cancer",
+                "subtype": "Cholangiocarcinoma",
+                "tissue": "Biliary Tract",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 400,
+                "code": "IHCH",
+                "color": "Green",
+                "level": 3,
+                "mainType": "Hepatobiliary Cancer",
+                "subtype": "Intrahepatic Cholangiocarcinoma",
+                "tissue": "Biliary Tract",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12758,105 +13615,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 112,
+            "id": 230,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 143,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 223,
+                "entity": "DRUG",
+                "rule": "67",
+                "name": null
+              },
+              {
+                "id": 224,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
-                "refResidues": null,
-                "variantResidues": null,
-                "genes": [
-                  {
-                    "id": 24498,
-                    "entrezGeneId": 1956,
-                    "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
-                  }
-                ],
-                "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
-                  "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5244,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 128,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 66,
-                    "uuid": "3de4c502-6c5e-4c10-93b6-f67976c56213",
-                    "name": "Mobocertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 67,
+                "uuid": "3de4c502-6c5e-4c10-93b6-f67976c56213",
+                "name": "Mobocertinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12872,77 +13708,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 113,
+            "id": 231,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 144,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 225,
+                "entity": "DRUG",
+                "rule": "86",
+                "name": null
+              },
+              {
+                "id": 226,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6078,
-                "type": "PROTEIN_CHANGE",
+                "id": 6181,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 129,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 85,
-                    "uuid": "37dd10c7-69c0-4d63-a171-8cb2570c1a54",
-                    "name": "Trastuzumab Deruxtecan"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 86,
+                "uuid": "37dd10c7-69c0-4d63-a171-8cb2570c1a54",
+                "name": "Trastuzumab Deruxtecan",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -12958,29 +13801,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 114,
+            "id": 232,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 145,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 227,
+                "entity": "DRUG",
+                "rule": "5",
+                "name": null
+              },
+              {
+                "id": 228,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15637,
+                "id": 15740,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -12989,110 +13831,122 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 5106,
+                    "id": 5121,
                     "entrezGeneId": 5979,
                     "hugoSymbol": "RET",
-                    "hgncId": "9967",
-                    "evidences": null
+                    "hgncId": "9967"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 130,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 5,
-                    "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
-                    "name": "Selpercatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 115,
+            "id": 233,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 146,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 182,
-                  "code": "THME",
-                  "color": "Teal",
-                  "level": 2,
-                  "mainType": "Thyroid Cancer",
-                  "subtype": "Medullary Thyroid Cancer",
-                  "tissue": "Thyroid",
-                  "tumorForm": "SOLID"
-                }
+                "id": 229,
+                "entity": "DRUG",
+                "rule": "5",
+                "name": null
+              },
+              {
+                "id": 230,
+                "entity": "CANCER_TYPE",
+                "rule": "182",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15636,
-                "type": "PROTEIN_CHANGE",
+                "id": 15739,
+                "type": "ANY",
                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "proteinChange": "",
                 "start": null,
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 5106,
+                    "id": 5121,
                     "entrezGeneId": 5979,
                     "hugoSymbol": "RET",
-                    "hgncId": "9967",
-                    "evidences": null
+                    "hgncId": "9967"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 131,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 5,
-                    "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
-                    "name": "Selpercatinib"
-                  }
-                ]
+                "id": 182,
+                "code": "THME",
+                "color": "Teal",
+                "level": 2,
+                "mainType": "Thyroid Cancer",
+                "subtype": "Medullary Thyroid Cancer",
+                "tissue": "Thyroid",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -13108,29 +13962,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 116,
+            "id": 234,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 147,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 155,
-                  "code": "THAP",
-                  "color": "Teal",
-                  "level": 2,
-                  "mainType": "Thyroid Cancer",
-                  "subtype": "Anaplastic Thyroid Cancer",
-                  "tissue": "Thyroid",
-                  "tumorForm": "SOLID"
-                }
+                "id": 231,
+                "entity": "DRUG",
+                "rule": "15+123",
+                "name": null
+              },
+              {
+                "id": 232,
+                "entity": "CANCER_TYPE",
+                "rule": "155",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -13139,13 +13992,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -13153,37 +14006,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 132,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 15,
-                    "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
-                    "name": "Dabrafenib"
-                  },
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
+                "id": 155,
+                "code": "THAP",
+                "color": "Teal",
+                "level": 2,
+                "mainType": "Thyroid Cancer",
+                "subtype": "Anaplastic Thyroid Cancer",
+                "tissue": "Thyroid",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 15,
+                "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
+                "name": "Dabrafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -13202,7 +14064,7 @@
     "manufacturer": "Abbott Molecular Inc.",
     "indicationDetails": null,
     "platformType": "FISH",
-    "lastUpdated": "2024-01-11T17:01:24.707172Z",
+    "lastUpdated": "2024-04-06T01:04:16.569351Z",
     "fdaSubmissions": [
       {
         "id": 73,
@@ -13216,29 +14078,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 117,
+            "id": 235,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 148,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 233,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 234,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -13247,62 +14108,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 133,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 134,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -13321,7 +14180,7 @@
     "manufacturer": "Ventana Medical Systems, Inc.",
     "indicationDetails": null,
     "platformType": "CISH",
-    "lastUpdated": "2024-01-11T17:01:25.439356Z",
+    "lastUpdated": "2024-04-06T01:04:16.998154Z",
     "fdaSubmissions": [
       {
         "id": 74,
@@ -13335,29 +14194,28 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 118,
+            "id": 236,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 149,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 235,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 236,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -13366,62 +14224,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 135,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 136,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -13440,7 +14296,7 @@
     "manufacturer": "Abbott Molecular Inc.",
     "indicationDetails": null,
     "platformType": "FISH",
-    "lastUpdated": "2024-01-11T17:01:26.628952Z",
+    "lastUpdated": "2024-04-06T01:04:18.003027Z",
     "fdaSubmissions": [
       {
         "id": 75,
@@ -13454,29 +14310,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 119,
+            "id": 237,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 150,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 237,
+                "entity": "DRUG",
+                "rule": "3",
+                "name": null
+              },
+              {
+                "id": 238,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
+                "id": 662,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -13485,46 +14340,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
+                    "id": 21829,
                     "entrezGeneId": 238,
                     "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 137,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 3,
-                    "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
-                    "name": "Crizotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 3,
+                "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
+                "name": "Crizotinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -13540,29 +14403,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 120,
+            "id": 238,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 151,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 239,
+                "entity": "DRUG",
+                "rule": "62",
+                "name": null
+              },
+              {
+                "id": 240,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
+                "id": 662,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -13571,46 +14433,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
+                    "id": 21829,
                     "entrezGeneId": 238,
                     "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 138,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 61,
-                    "uuid": "e3f55518-0ebb-4998-9e78-3124b5b987ec",
-                    "name": "Brigatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 62,
+                "uuid": "e3f55518-0ebb-4998-9e78-3124b5b987ec",
+                "name": "Brigatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -13629,7 +14499,7 @@
     "manufacturer": "Tempus Labs, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:27.506445Z",
+    "lastUpdated": "2024-04-06T01:04:18.737786Z",
     "fdaSubmissions": [
       {
         "id": 77,
@@ -13643,29 +14513,28 @@
         "curated": true,
         "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 121,
+            "id": 239,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 152,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 241,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 242,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -13674,13 +14543,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -13688,64 +14557,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 139,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
-              },
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
               {
-                "id": 140,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
+              },
+              {
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 122,
+            "id": 240,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 153,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 243,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 244,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -13754,13 +14617,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -13768,64 +14631,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 141,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 142,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 123,
+            "id": 241,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 154,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 245,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 246,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
+                "id": 12919,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -13834,13 +14691,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 17596,
+                    "id": 17611,
                     "entrezGeneId": 4893,
                     "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "hgncId": "7989"
                   }
                 ],
                 "consequence": {
@@ -13848,48 +14705,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 143,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 144,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -13918,7 +14773,7 @@
     "manufacturer": "ARUP Laboratories, Inc.",
     "indicationDetails": null,
     "platformType": "FISH",
-    "lastUpdated": "2024-01-11T17:01:27.827271Z",
+    "lastUpdated": "2024-04-06T01:04:19.150156Z",
     "fdaSubmissions": [
       {
         "id": 78,
@@ -13932,29 +14787,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 124,
+            "id": 242,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 155,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 380,
-                  "code": "MDS/MPN",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Myelodysplastic/Myeloproliferative Neoplasms",
-                  "subtype": "Myelodysplastic/Myeloproliferative Neoplasms",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 247,
+                "entity": "DRUG",
+                "rule": "139",
+                "name": null
+              },
+              {
+                "id": 248,
+                "entity": "CANCER_TYPE",
+                "rule": "380",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13310,
+                "id": 13413,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -13963,46 +14817,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41957,
+                    "id": 41818,
                     "entrezGeneId": 5159,
                     "hugoSymbol": "PDGFRB",
-                    "hgncId": "8804",
-                    "evidences": null
+                    "hgncId": "8804"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 145,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 138,
-                    "uuid": "f42768c5-4918-4244-98dd-6ea97a4d3c2a",
-                    "name": "Imatinib"
-                  }
-                ]
+                "id": 380,
+                "code": "MDS/MPN",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Myelodysplastic/Myeloproliferative Neoplasms",
+                "subtype": "Myelodysplastic/Myeloproliferative Neoplasms",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 139,
+                "uuid": "f42768c5-4918-4244-98dd-6ea97a4d3c2a",
+                "name": "Imatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 3,
-          "type": "HDE",
+          "type": "DEVICE_HDE",
           "name": "Humanitarian Device Exemption",
           "shortName": "HDE",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Searchable listing of Humanitarian Device Exemption (HDE) Class III medical devices."
         }
       }
@@ -14021,7 +14883,7 @@
     "manufacturer": "Illumina, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:28.384713Z",
+    "lastUpdated": "2024-04-06T01:04:19.594582Z",
     "fdaSubmissions": [
       {
         "id": 79,
@@ -14035,29 +14897,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 125,
+            "id": 243,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 156,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 249,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 250,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -14066,13 +14927,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -14080,64 +14941,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 146,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 147,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 126,
+            "id": 244,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 157,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 251,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 252,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
+                "id": 12919,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -14146,13 +15001,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 17596,
+                    "id": 17611,
                     "entrezGeneId": 4893,
                     "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "hgncId": "7989"
                   }
                 ],
                 "consequence": {
@@ -14160,48 +15015,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 148,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 149,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -14220,7 +15073,7 @@
     "manufacturer": "Life Technologies Corporation",
     "indicationDetails": null,
     "platformType": "CISH",
-    "lastUpdated": "2024-01-11T17:01:29.049550Z",
+    "lastUpdated": "2024-04-06T01:04:20.309542Z",
     "fdaSubmissions": [
       {
         "id": 80,
@@ -14234,29 +15087,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 127,
+            "id": 245,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 158,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 253,
+                "entity": "DRUG",
+                "rule": "39,39+104",
+                "name": null
+              },
+              {
+                "id": 254,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 6079,
+                "id": 6182,
                 "type": "COPY_NUMBER_ALTERATION",
                 "name": "Amplification",
                 "alteration": "Amplification",
@@ -14265,62 +15117,60 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 7677,
+                    "id": 7706,
                     "entrezGeneId": 2064,
                     "hugoSymbol": "ERBB2",
-                    "hgncId": "3430",
-                    "evidences": null
+                    "hgncId": "3430"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 150,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 39,
+                "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
+                "name": "Trastuzumab",
+                "fdaDrugs": null
               },
               {
-                "id": 151,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 38,
-                    "uuid": "b29b3641-d866-4b09-bff6-3063d8316935",
-                    "name": "Trastuzumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -14339,7 +15189,7 @@
     "manufacturer": "QIAGEN GmbH",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:29.493351Z",
+    "lastUpdated": "2024-04-06T01:04:21.041617Z",
     "fdaSubmissions": [
       {
         "id": 81,
@@ -14353,29 +15203,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 128,
+            "id": 246,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 159,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 255,
+                "entity": "DRUG",
+                "rule": "118+124",
+                "name": null
+              },
+              {
+                "id": 256,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -14384,13 +15233,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -14398,37 +15247,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 152,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -14447,7 +15305,7 @@
     "manufacturer": "Qiagen Manchester, Ltd.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:32.262924Z",
+    "lastUpdated": "2024-04-06T01:04:22.874370Z",
     "fdaSubmissions": [
       {
         "id": 82,
@@ -14461,29 +15319,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 129,
+            "id": 247,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 160,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 257,
+                "entity": "DRUG",
+                "rule": "59",
+                "name": null
+              },
+              {
+                "id": 258,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -14492,13 +15349,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14506,60 +15363,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 153,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -14575,29 +15439,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 130,
+            "id": 248,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 161,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 259,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 260,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -14606,13 +15469,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14620,60 +15483,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 154,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -14689,29 +15559,69 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 131,
+            "id": 270,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [],
+            "alterations": [
               {
-                "id": 162,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
+                "id": 5127,
+                "type": "PROTEIN_CHANGE",
+                "name": "G719",
+                "alteration": "G719",
+                "proteinChange": "G719",
+                "start": 719,
+                "end": 719,
+                "refResidues": "G",
+                "variantResidues": "",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
+                  }
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
                 }
-              }
-            ],
-            "alterations": [
+              },
+              {
+                "id": 5142,
+                "type": "PROTEIN_CHANGE",
+                "name": "S768I",
+                "alteration": "S768I",
+                "proteinChange": "S768I",
+                "start": 768,
+                "end": 768,
+                "refResidues": "S",
+                "variantResidues": "I",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
+                  }
+                ],
+                "consequence": {
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
+                  "isGenerallyTruncating": false,
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
+                }
+              },
               {
-                "id": 5041,
+                "id": 5144,
                 "type": "PROTEIN_CHANGE",
                 "name": "L861Q",
                 "alteration": "L861Q",
@@ -14720,13 +15630,13 @@
                 "end": 861,
                 "refResidues": "L",
                 "variantResidues": "Q",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14734,32 +15644,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 155,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -14775,29 +15693,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 132,
+            "id": 250,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 163,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 263,
+                "entity": "DRUG",
+                "rule": "88",
+                "name": null
+              },
+              {
+                "id": 264,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -14806,13 +15723,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14820,60 +15737,67 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 156,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 87,
-                    "uuid": "ee16e91a-38a2-4433-97d2-9b9ae9d2a497",
-                    "name": "Dacomitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 88,
+                "uuid": "ee16e91a-38a2-4433-97d2-9b9ae9d2a497",
+                "name": "Dacomitinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -14892,7 +15816,7 @@
     "manufacturer": "QIAGEN Manchester Ltd.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:32.693221Z",
+    "lastUpdated": "2024-04-06T01:04:23.342470Z",
     "fdaSubmissions": [
       {
         "id": 86,
@@ -14906,29 +15830,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 133,
+            "id": 251,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 164,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 977,
-                  "code": null,
-                  "color": "Yellow",
-                  "level": 0,
-                  "mainType": "Bladder Cancer",
-                  "subtype": null,
-                  "tissue": "Bladder/Urinary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 265,
+                "entity": "DRUG",
+                "rule": "94",
+                "name": null
+              },
+              {
+                "id": 266,
+                "entity": "CANCER_TYPE",
+                "rule": "977",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8245,
+                "id": 8348,
                 "type": "PROTEIN_CHANGE",
                 "name": "R248C",
                 "alteration": "R248C",
@@ -14937,13 +15860,13 @@
                 "end": 248,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -14951,12 +15874,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8246,
+                "id": 8349,
                 "type": "PROTEIN_CHANGE",
                 "name": "S249C",
                 "alteration": "S249C",
@@ -14965,13 +15887,13 @@
                 "end": 249,
                 "refResidues": "S",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -14979,12 +15901,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8247,
+                "id": 8350,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y373C",
                 "alteration": "Y373C",
@@ -14993,13 +15914,13 @@
                 "end": 373,
                 "refResidues": "Y",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -15007,12 +15928,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8282,
+                "id": 8385,
                 "type": "PROTEIN_CHANGE",
                 "name": "G370C",
                 "alteration": "G370C",
@@ -15021,13 +15941,13 @@
                 "end": 370,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -15035,12 +15955,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8287,
+                "id": 8390,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -15049,46 +15968,54 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
-            "articles": null,
-            "treatments": [
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 977,
+                "code": null,
+                "color": "Yellow",
+                "level": 0,
+                "mainType": "Bladder Cancer",
+                "subtype": null,
+                "tissue": "Bladder/Urinary Tract",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
               {
-                "id": 157,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 93,
-                    "uuid": "f2e41d69-c383-4e33-ba25-0bf5f837db11",
-                    "name": "Erdafitinib"
-                  }
-                ]
+                "id": 94,
+                "uuid": "f2e41d69-c383-4e33-ba25-0bf5f837db11",
+                "name": "Erdafitinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -15107,7 +16034,7 @@
     "manufacturer": "Qiagen Manchester, Ltd.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:34.466152Z",
+    "lastUpdated": "2024-04-06T01:04:24.395416Z",
     "fdaSubmissions": [
       {
         "id": 87,
@@ -15121,29 +16048,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 134,
+            "id": 252,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 165,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 267,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 268,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15152,13 +16078,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15166,48 +16092,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 158,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 159,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -15223,29 +16147,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 135,
+            "id": 253,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 166,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 269,
+                "entity": "DRUG",
+                "rule": "17",
+                "name": null
+              },
+              {
+                "id": 270,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -15254,13 +16177,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15268,32 +16191,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 160,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 17,
-                    "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
-                    "name": "Sotorasib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 17,
+                "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
+                "name": "Sotorasib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -15309,29 +16240,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 136,
+            "id": 254,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 167,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 271,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 272,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15340,13 +16270,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15354,48 +16284,46 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 161,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               },
               {
-                "id": 162,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -15411,29 +16339,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 137,
+            "id": 255,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 168,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 273,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 274,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15442,13 +16369,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15456,64 +16383,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 163,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               },
               {
-                "id": 164,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  },
-                  {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 138,
+            "id": 256,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 169,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 275,
+                "entity": "DRUG",
+                "rule": "121",
+                "name": null
+              },
+              {
+                "id": 276,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -15522,13 +16443,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15536,32 +16457,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 165,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 120,
-                    "uuid": "0a7b3eb1-d1f0-4511-aaac-9a696955bf57",
-                    "name": "Adagrasib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 121,
+                "uuid": "0a7b3eb1-d1f0-4511-aaac-9a696955bf57",
+                "name": "Adagrasib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -15580,7 +16509,7 @@
     "manufacturer": "QIAGEN GmbH",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:35.144681Z",
+    "lastUpdated": "2024-04-06T01:04:24.862345Z",
     "fdaSubmissions": [
       {
         "id": 91,
@@ -15594,77 +16523,84 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 139,
+            "id": 257,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 170,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 219,
-                  "code": "GIST",
-                  "color": "LightYellow",
-                  "level": 2,
-                  "mainType": "Gastrointestinal Stromal Tumor",
-                  "subtype": "Gastrointestinal Stromal Tumor",
-                  "tissue": "Soft Tissue",
-                  "tumorForm": "SOLID"
-                }
+                "id": 277,
+                "entity": "DRUG",
+                "rule": "74",
+                "name": null
+              },
+              {
+                "id": 278,
+                "entity": "CANCER_TYPE",
+                "rule": "219",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13273,
+                "id": 22644,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 18 missense mutations",
-                "alteration": "814_852mis",
-                "proteinChange": "814_852mis",
-                "start": 814,
-                "end": 852,
+                "alteration": "Exon 18 missense mutations",
+                "proteinChange": "Exon 18 missense mutations",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41967,
+                    "id": 41828,
                     "entrezGeneId": 5156,
                     "hugoSymbol": "PDGFRA",
-                    "hgncId": "8803",
-                    "evidences": null
+                    "hgncId": "8803"
                   }
                 ],
                 "consequence": {
-                  "id": 16,
-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 166,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 73,
-                    "uuid": "3d49e386-0cc4-401e-9acd-d2d33b2923a3",
-                    "name": "Avapritinib"
-                  }
-                ]
+                "id": 219,
+                "code": "GIST",
+                "color": "LightYellow",
+                "level": 2,
+                "mainType": "Gastrointestinal Stromal Tumor",
+                "subtype": "Gastrointestinal Stromal Tumor",
+                "tissue": "Soft Tissue",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 74,
+                "uuid": "3d49e386-0cc4-401e-9acd-d2d33b2923a3",
+                "name": "Avapritinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
@@ -15683,7 +16619,7 @@
     "manufacturer": "QIAGEN GmbH",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:35.815793Z",
+    "lastUpdated": "2024-09-24T16:40:32.380917Z",
     "fdaSubmissions": [
       {
         "id": 92,
@@ -15697,44 +16633,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 140,
+            "id": 258,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 171,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 279,
+                "entity": "DRUG",
+                "rule": "84+33",
+                "name": null
+              },
+              {
+                "id": 280,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13431,
+                "id": 13532,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
+                "variantResidues": "D",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15742,12 +16677,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13426,
+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -15756,13 +16690,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15770,12 +16704,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13427,
+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -15784,13 +16717,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15798,27 +16731,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13428,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545A",
-                "alteration": "E545A",
-                "proteinChange": "E545A",
-                "start": 545,
-                "end": 545,
-                "refResidues": "E",
-                "variantResidues": "A",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
+                "start": 1047,
+                "end": 1047,
+                "refResidues": "H",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15826,27 +16758,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13429,
+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545A",
+                "alteration": "E545A",
+                "proteinChange": "E545A",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "A",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15854,12 +16785,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545G",
                 "alteration": "E545G",
@@ -15868,13 +16798,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15882,27 +16812,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546E",
-                "alteration": "Q546E",
-                "proteinChange": "Q546E",
-                "start": 546,
-                "end": 546,
-                "refResidues": "Q",
-                "variantResidues": "E",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
+                "start": 545,
+                "end": 545,
+                "refResidues": "E",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15910,27 +16839,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546R",
-                "alteration": "Q546R",
-                "proteinChange": "Q546R",
+                "name": "Q546E",
+                "alteration": "Q546E",
+                "proteinChange": "Q546E",
                 "start": 546,
                 "end": 546,
                 "refResidues": "Q",
-                "variantResidues": "R",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15938,27 +16866,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047R",
+                "alteration": "H1047R",
+                "proteinChange": "H1047R",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15966,27 +16893,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047R",
-                "alteration": "H1047R",
-                "proteinChange": "H1047R",
-                "start": 1047,
-                "end": 1047,
-                "refResidues": "H",
+                "name": "Q546R",
+                "alteration": "Q546R",
+                "proteinChange": "Q546R",
+                "start": 546,
+                "end": 546,
+                "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15994,27 +16920,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16022,37 +16947,46 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 167,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -16068,44 +17002,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 140,
+            "id": 258,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 171,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 279,
+                "entity": "DRUG",
+                "rule": "84+33",
+                "name": null
+              },
+              {
+                "id": 280,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 13431,
+                "id": 13532,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
+                "variantResidues": "D",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16113,12 +17046,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13426,
+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -16127,13 +17059,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16141,12 +17073,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13427,
+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -16155,13 +17086,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16169,27 +17100,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13428,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545A",
-                "alteration": "E545A",
-                "proteinChange": "E545A",
-                "start": 545,
-                "end": 545,
-                "refResidues": "E",
-                "variantResidues": "A",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
+                "start": 1047,
+                "end": 1047,
+                "refResidues": "H",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16197,27 +17127,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13429,
+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545A",
+                "alteration": "E545A",
+                "proteinChange": "E545A",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "A",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16225,12 +17154,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545G",
                 "alteration": "E545G",
@@ -16239,13 +17167,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16253,27 +17181,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546E",
-                "alteration": "Q546E",
-                "proteinChange": "Q546E",
-                "start": 546,
-                "end": 546,
-                "refResidues": "Q",
-                "variantResidues": "E",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
+                "start": 545,
+                "end": 545,
+                "refResidues": "E",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16281,27 +17208,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
-                "name": "Q546R",
-                "alteration": "Q546R",
-                "proteinChange": "Q546R",
+                "name": "Q546E",
+                "alteration": "Q546E",
+                "proteinChange": "Q546E",
                 "start": 546,
                 "end": 546,
                 "refResidues": "Q",
-                "variantResidues": "R",
+                "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16309,27 +17235,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047R",
+                "alteration": "H1047R",
+                "proteinChange": "H1047R",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16337,27 +17262,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047R",
-                "alteration": "H1047R",
-                "proteinChange": "H1047R",
-                "start": 1047,
-                "end": 1047,
-                "refResidues": "H",
+                "name": "Q546R",
+                "alteration": "Q546R",
+                "proteinChange": "Q546R",
+                "start": 546,
+                "end": 546,
+                "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16365,27 +17289,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16393,42 +17316,56 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 167,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
     ],
     "specimenTypes": [
+      {
+        "id": 1,
+        "type": "CFDNA",
+        "name": "cfDNA from plasma"
+      },
       {
         "id": 3,
         "type": "FFPE",
@@ -16442,7 +17379,7 @@
     "manufacturer": "bioMérieux Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:36.986892Z",
+    "lastUpdated": "2024-04-06T01:04:27.506321Z",
     "fdaSubmissions": [
       {
         "id": 94,
@@ -16456,29 +17393,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 141,
+            "id": 259,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 172,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 281,
+                "entity": "DRUG",
+                "rule": "123",
+                "name": null
+              },
+              {
+                "id": 282,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16487,13 +17423,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16501,12 +17437,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -16515,13 +17450,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16529,48 +17464,52 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 168,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 142,
+            "id": 260,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 173,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 283,
+                "entity": "DRUG",
+                "rule": "15",
+                "name": null
+              },
+              {
+                "id": 284,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16579,13 +17518,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16593,32 +17532,40 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 169,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 15,
-                    "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
-                    "name": "Dabrafenib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 15,
+                "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
+                "name": "Dabrafenib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       },
@@ -16634,29 +17581,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 143,
+            "id": 261,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 174,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 285,
+                "entity": "DRUG",
+                "rule": "118+120",
+                "name": null
+              },
+              {
+                "id": 286,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16665,13 +17611,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16679,12 +17625,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -16693,13 +17638,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16707,37 +17652,308 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 170,
-                "name": null,
-                "drugs": [
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 120,
+                "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
+                "name": "Binimetinib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ],
+        "type": {
+          "id": 1,
+          "type": "DEVICE_PMA",
+          "name": "Premarket Approval",
+          "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
+          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
+        }
+      }
+    ],
+    "specimenTypes": [
+      {
+        "id": 3,
+        "type": "FFPE",
+        "name": "FFPE"
+      }
+    ]
+  },
+  {
+    "id": 40,
+    "name": "TruSight Oncology Comprehensive",
+    "manufacturer": "Illumina, Inc.",
+    "indicationDetails": "",
+    "platformType": "NGS",
+    "lastUpdated": "2024-10-22T15:11:21.096078Z",
+    "fdaSubmissions": [
+      {
+        "id": 98,
+        "number": "P230011",
+        "supplementNumber": "",
+        "deviceName": "TruSight Oncology Comprehensive",
+        "genericName": "",
+        "dateReceived": "2024-10-22T04:00:00Z",
+        "decisionDate": "2024-10-22T04:00:00Z",
+        "description": "",
+        "curated": false,
+        "genetic": false,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 265,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 15740,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
+                    "id": 5121,
+                    "entrezGeneId": 5979,
+                    "hugoSymbol": "RET",
+                    "hgncId": "9967"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 266,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13094,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20523,
+                    "entrezGeneId": 4914,
+                    "hugoSymbol": "NTRK1",
+                    "hgncId": "8031"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 267,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13153,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20524,
+                    "entrezGeneId": 4915,
+                    "hugoSymbol": "NTRK2",
+                    "hgncId": "8032"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 268,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13173,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 119,
-                    "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
-                    "name": "Binimetinib"
+                    "id": 38985,
+                    "entrezGeneId": 4916,
+                    "hugoSymbol": "NTRK3",
+                    "hgncId": "8033"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
               }
             ]
           }
         ],
         "type": {
           "id": 1,
-          "type": "PMA",
+          "type": "DEVICE_PMA",
           "name": "Premarket Approval",
           "shortName": "PMA",
+          "submissionPrefix": null,
+          "submissionLink": null,
           "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
         }
       }
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
index 4bac79214..cd46d6640 100644
--- a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
+++ b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
@@ -90,11 +90,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "1998-2001*",
-    "tx": "Imatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)\nKIT+\nPDGFRA, PDGFRB Fusions\nPDGFB Fusions\nFIP1L1-PDGFRA Fusion",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include BCR-ABL, KIT, PDGFRA)",
+    "year": "2018",
+    "tx": "Lorlatinib",
+    "biomarker": "ALK+ (ALK Fusions)",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include ALK and ROS1 among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -211,9 +211,9 @@
   },
   {
     "year": "2003",
-    "tx": "Tositumomab and Iodine I 131 Tositumomab*",
+    "tx": "Tositumomab and Iodine I 131 Tositumomab",
     "biomarker": "CD20+",
-    "agentClass": "Hematopoietic protein binding antibody, ADC* or cytotoxin",
+    "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "Anti-CD20 antibody",
     "targetedTx": "Y",
     "pxTx": "Y",
@@ -290,24 +290,24 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2005",
-    "tx": "Sorafenib",
-    "biomarker": "",
+    "year": "1998-2001*",
+    "tx": "Imatinib",
+    "biomarker": "*Ph+ (BCR-ABL1 Fusion)\n*KIT+\n*PDGFRA, PDGFRB Fusions\n*PDGFB Fusions\n*FIP1L1-PDGFRA fusion",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, BRAF, KIT, FLT3 and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include BCR-ABL, KIT, PDGFRA)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
-    "year": "2006",
-    "tx": "Dasatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
+    "year": "2019",
+    "tx": "Pexidartinib",
+    "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include SRC, BCR-ABL1, KIT and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include CSF1R, KIT and FLT3)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2006",
@@ -340,11 +340,11 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2006",
-    "tx": "Sunitinib",
-    "biomarker": "KIT+",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, KIT, FLT3, CSF1R and PDGFRɑ/β among others)",
+    "year": "2019",
+    "tx": "Erdafitinib",
+    "biomarker": "FGFR3-TACC3 Fusion, FGFR3-BAIAP2L1 Fusion, FGFR3 S249C, R248C, G370C, Y373C",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include FGFR1/2/3/4 among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -380,11 +380,11 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2007",
-    "tx": "Nilotinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
+    "year": "2017",
+    "tx": "Midostaurin",
+    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, PDGFR and KIT among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include FLT3, VEGFR2, KIT and PDGFR)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -422,7 +422,7 @@
   {
     "year": "2009",
     "tx": "Everolimus",
-    "biomarker": "TSC1, TSC2 Oncogenic Mutations",
+    "biomarker": "TSC1, TSC2 Oncogenic Mutations",
     "agentClass": "Large molecule inhibitor",
     "drugTarget": "mTOR inhibitor",
     "targetedTx": "Y",
@@ -440,11 +440,11 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2009",
-    "tx": "Pazopanib",
+    "year": "2019",
+    "tx": "Fedratinib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include VEGFR1/2/3, PDGFRɑ/β, KIT, FGFR1/3 among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include JAK2 and FLT3)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
@@ -530,11 +530,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "2011",
-    "tx": "Crizotinib",
-    "biomarker": "ALK+ (ALK Fusions)\nROS1+ (ROS1 Fusions)",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include ALK, ROS1 and MET)",
+    "year": "2020",
+    "tx": "Avapritinib",
+    "biomarker": "*PDGFRA Exon 18 Mutations\n*KIT D816",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include KIT D816V, PDGFRA, PDGFRA D842, KIT exon 11, 11/17 and 17 mutants)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -570,14 +570,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2011",
-    "tx": "Vandetanib",
-    "biomarker": "",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR, EGFR and RET)",
+    "year": "2019",
+    "tx": "Entrectinib",
+    "biomarker": "*NTRK1, NTRK2, NTRK3 Fusions\n*ROS1 Fusions",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include NTRK1/2/3, ROS1 and ALK among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2011",
@@ -610,25 +610,25 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2012",
-    "tx": "Bosutinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1 and SRC family kinases)",
-    "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
-  },
-  {
-    "year": "2012",
-    "tx": "Cabozantinib",
+    "year": "2021",
+    "tx": "Umbralisib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, AXL, KIT, RET and ROS1 among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include PI3Kδ and CK1ε among others)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
+  {
+    "year": "2023",
+    "tx": "Repotrectinib",
+    "biomarker": "*ROS1 Fusions \n*NTRK Fusions",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include ROS1 and NTRK1/2/3)",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
   {
     "year": "2012",
     "tx": "Carfilzomib",
@@ -670,24 +670,24 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2012",
-    "tx": "Ponatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion) or ABL1 T315I",
+    "year": "2006",
+    "tx": "Dasatinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, VEGFR, PDGFR, FGFR and SRC family members among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include SRC, BCR-ABL1, KIT and PDGFRβ among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
-    "year": "2012",
-    "tx": "Regorafenib",
-    "biomarker": "KIT+",
+    "year": "2005",
+    "tx": "Sorafenib",
+    "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include KIT, RET, VEGFR1/2/3, FGFR1/2, PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, BRAF, KIT, FLT3 and PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2012",
@@ -743,7 +743,7 @@
     "year": "2013",
     "tx": "Obinutuzumab",
     "biomarker": "",
-    "agentClass": "Hematopoietic protein binding antibody, ADC* or cytotoxin",
+    "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "Anti-CD20 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
@@ -862,7 +862,7 @@
   {
     "year": "2014",
     "tx": "Olaparib",
-    "biomarker": "BRCA1, BRCA2 Oncogenic Mutations\nATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1/2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54 Oncogenic Mutations",
+    "biomarker": "*BRCA1, BRCA2 Oncogenic Mutations  *ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54 Oncogenic Mutations",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "PARP inhibitor",
     "targetedTx": "Y",
@@ -872,7 +872,7 @@
   {
     "year": "2014",
     "tx": "Pembrolizumab",
-    "biomarker": "MSI-H or dMMR\nTMB-H\nPD-L1-expression\npMMR",
+    "biomarker": "*MSI-H or dMMR\n*TMB-H\n*PD-L1-expressing\n*pMMR",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-PD-1 antibody",
     "targetedTx": "Y",
@@ -911,10 +911,10 @@
   },
   {
     "year": "2015",
-    "tx": "Cobimetinib + Vemurafenib",
+    "tx": "Vemurafenib + Cobimetinib ",
     "biomarker": "BRAF V600E/K",
-    "agentClass": "Small molecule inhibitor combination",
-    "drugTarget": "MEK1/2 inhibitor + BRAF inhibitor",
+    "agentClass": "Small molecule kinase inhibitor combination",
+    "drugTarget": "BRAF inhibitor + MEK1/2 inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -952,7 +952,7 @@
   {
     "year": "2015",
     "tx": "Ipilimumab + Nivolumab",
-    "biomarker": "MSI-H or dMMR\nPD-L1-expressing",
+    "biomarker": "*MSI-H or dMMR\n*PD-L1-expressing",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-CTLA-4 antibody + Anti-PD1 antibody",
     "targetedTx": "Y",
@@ -970,11 +970,11 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2015",
-    "tx": "Lenvatinib",
+    "year": "2021",
+    "tx": "Tivozanib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, FGFR1/2/3/4, KIT, RET and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, KIT and PDGFRβ)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
@@ -1011,7 +1011,7 @@
   },
   {
     "year": "2015",
-    "tx": "Panobinostat*",
+    "tx": "Panobinostat",
     "biomarker": "",
     "agentClass": "HDAC inhibitor",
     "drugTarget": "Histone deacetylase (HDAC) inhibitor",
@@ -1071,7 +1071,7 @@
   },
   {
     "year": "2016",
-    "tx": "Olaratumab*",
+    "tx": "Olaratumab",
     "biomarker": "",
     "agentClass": "Monoclonal antibody",
     "drugTarget": "Anti-PDGFRɑ antibody",
@@ -1172,12 +1172,12 @@
   {
     "year": "2017",
     "tx": "Durvalumab",
-    "biomarker": "",
+    "biomarker": "dMMR",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-PDL-1 antibody",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "N"
   },
   {
     "year": "2017",
@@ -1192,7 +1192,7 @@
   {
     "year": "2017",
     "tx": "Inotuzumab Ozogamicin",
-    "biomarker": "CD22",
+    "biomarker": "CD22+",
     "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "CD22-directed antibody-drug conjugate",
     "targetedTx": "Y",
@@ -1200,11 +1200,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "2017",
-    "tx": "Midostaurin",
-    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
+    "year": "2011",
+    "tx": "Crizotinib",
+    "biomarker": "*ALK+ (ALK Fusions)\n*ROS1+ (ROS1 Fusions)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include FLT3, VEGFR2, KIT and PDGFR)",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include ALK, ROS1 and MET)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1214,7 +1214,7 @@
     "tx": "Neratinib",
     "biomarker": "HER2+ (ERBB2 Amplification)",
     "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "EGFR/HER2 (ERBB2)/HER4 (ERBB4) inhibitor",
+    "drugTarget": "EGFR//HER2 (ERBB2)/HER4 (ERBB4) inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1261,10 +1261,10 @@
   },
   {
     "year": "2018",
-    "tx": "Binimetinib + Encorafenib",
+    "tx": "Encorafenib + Binimetinib",
     "biomarker": "BRAF V600E/K",
-    "agentClass": "Small molecule inhibitor combination",
-    "drugTarget": "MEK1/2 inhibitor + BRAF inhibitor",
+    "agentClass": "Small molecule kinase inhibitor combination",
+    "drugTarget": "BRAF inhibitor + MEK1/2 inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1310,14 +1310,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2018",
-    "tx": "Gilteritinib",
-    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include mutant and WT FLT3, AXL and ALK)",
+    "year": "2011",
+    "tx": "Vandetanib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR, EGFR and RET)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2018",
@@ -1360,14 +1360,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2018",
-    "tx": "Lorlatinib",
-    "biomarker": "ALK+ (ALK Fusions)",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include ALK and ROS1 among others)",
+    "year": "2012",
+    "tx": "Cabozantinib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, AXL, KIT, RET and ROS1 among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2018",
@@ -1412,7 +1412,7 @@
   {
     "year": "2018",
     "tx": "Talazoparib",
-    "biomarker": "BRCA1, BRCA2 Oncogenic Mutations\nATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11, NBN, PALB2, RAD51C Oncogenic Mutations",
+    "biomarker": "*BRCA1, BRCA2 Oncogenic Mutations\n*ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11, NBN, PALB2, RAD51C\nOncogenic Mutations",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "PARP inhibitor",
     "targetedTx": "Y",
@@ -1450,44 +1450,44 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2019",
-    "tx": "Entrectinib",
-    "biomarker": "NTRK1, NTRK2, NTRK3 Fusions\nROS1 Fusions",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include NTRK1/2/3, ROS1 and ALK among others)",
+    "year": "2015",
+    "tx": "Lenvatinib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, FGFR1/2/3/4, KIT, RET and PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
-    "year": "2019",
-    "tx": "Erdafitinib",
-    "biomarker": "FGFR3-TACC3 Fusion, FGFR3-BAIAP2L1 Fusion, FGFR3 S249C, R248C, G370C, Y373C",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include FGFR1/2/3/4 among others)",
+    "year": "2006",
+    "tx": "Sunitinib",
+    "biomarker": "KIT+",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, KIT, FLT3, CSF1R and PDGFRɑ/β among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
-    "year": "2019",
-    "tx": "Fedratinib",
-    "biomarker": "",
+    "year": "2012",
+    "tx": "Bosutinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include JAK2 and FLT3)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1 and SRC family kinases)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
-    "year": "2019",
-    "tx": "Pexidartinib",
-    "biomarker": "",
+    "year": "2007",
+    "tx": "Nilotinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include CSF1R, KIT and FLT3)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, PDGFR and KIT among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2019",
@@ -1512,7 +1512,7 @@
   {
     "year": "2019",
     "tx": "Trastuzumab deruxtecan",
-    "biomarker": "HER2+ (ERBB2 Amplification)\nHER2-low\nERBB2 Oncogenic Mutations",
+    "biomarker": "*HER2+ (ERBB2 Amplification)\n*HER2-low\n*ERBB2 Oncogenic Mutations",
     "agentClass": "Antibody drug conjugate",
     "drugTarget": "HER2 (ERBB2)-directed antibody and topoisomerase inhibitor conjugate",
     "targetedTx": "Y",
@@ -1540,18 +1540,18 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2020",
-    "tx": "Avapritinib",
-    "biomarker": "PDGFRA Exon 18 Mutations\nKIT D816",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include KIT D816V, PDGFRA, PDGFRA D842, KIT exon 11, 11/17 and 17 mutants)",
+    "year": "2012",
+    "tx": "Ponatinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion) or\nABL1 T315I",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, VEGFR, PDGFR, FGFR and SRC family members among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
     "year": "2020",
-    "tx": "Belantamab mafodotin*",
+    "tx": "Belantamab mafodotin",
     "biomarker": "",
     "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "BCMA-directed antibody-drug conjugate",
@@ -1594,7 +1594,7 @@
     "tx": "Encorafenib + Cetuximab",
     "biomarker": "BRAF V600E",
     "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
-    "drugTarget": "BRAF inhibitor + Anti-EGFR monoclonal antibody",
+    "drugTarget": "BRAF inhibitor + Anti-EGFR antibody",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1637,12 +1637,12 @@
     "drugTarget": "Anti-GD2 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
-    "ngsTest": "NA"
+    "ngsTest": ""
   },
   {
     "year": "2020",
     "tx": "Pemigatinib",
-    "biomarker": "FGFR2 Fusions\nFGFR1 Fusions",
+    "biomarker": "*FGFR2 Fusions\n*FGFR1 Fusions",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "FGFR1/2/3 inhibitor",
     "targetedTx": "Y",
@@ -1672,9 +1672,9 @@
   {
     "year": "2020",
     "tx": "Ripretinib",
-    "biomarker": "KIT+",
+    "biomarker": "KIT/PDGFRA inhibitor",
     "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "KIT/PDGFRA inhibitor",
+    "drugTarget": "KIT/PDGFRA D816",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1722,7 +1722,7 @@
   {
     "year": "2020",
     "tx": "Tazemetostat",
-    "biomarker": "EZH2 Y646F, A692V, Y646C, Y646S, Y646N, Y646H, A682G\nSMARCB1 Deletion",
+    "biomarker": "*EZH2 Y646F, A692V, Y646C, Y646S, Y646N, Y646H, A682G\n*SMARCB1 Deletion",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "EZH2 inhibitor (methyltransferase inhibitor)",
     "targetedTx": "Y",
@@ -1732,7 +1732,7 @@
   {
     "year": "2020",
     "tx": "Tucatinib + Trastuzumab",
-    "biomarker": "HER2+ (ERBB2 Amplifiaction)\nKRAS and NRAS  Wildtype, and HER2+ (ERBB2 Amplifiaction)",
+    "biomarker": "*HER2+ (ERBB2 Amplifiaction)\n*KRAS and NRAS Wildtype and HER2+ (ERBB2 Amplification)",
     "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
     "drugTarget": "HER2 (ERBB2) inhibitor + Anti-HER2 (ERBB2) antibody",
     "targetedTx": "Y",
@@ -1742,7 +1742,7 @@
   {
     "year": "2021",
     "tx": "Amivantamab",
-    "biomarker": "EGFR Exon 20 Insertions",
+    "biomarker": "*EGFR Exon 20 Insertions \n*EGFR Exon 19 Deletions, L858R",
     "agentClass": "Monoclonal antibody",
     "drugTarget": "EGFR-MET bispecific antibody",
     "targetedTx": "Y",
@@ -1752,7 +1752,7 @@
   {
     "year": "2021",
     "tx": "Asciminib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion) or ABL1 T315I",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)\nor ABL1 T315I",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "ABL/BCR-ABL1 tyrosine kinase inhibitor",
     "targetedTx": "Y",
@@ -1772,7 +1772,7 @@
   {
     "year": "2021",
     "tx": "Dostarlimab",
-    "biomarker": "dMMR\ndMMR or MSI-H",
+    "biomarker": "*dMMR                                                     *dMMR or MSI-H",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti PD-1 antibody",
     "targetedTx": "Y",
@@ -1791,7 +1791,7 @@
   },
   {
     "year": "2021",
-    "tx": "Infigratinib*",
+    "tx": "Infigratinib",
     "biomarker": "FGFR2 Fusions",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "FGFR1/2/3 inhibitor",
@@ -1880,14 +1880,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2021",
-    "tx": "Tivozanib",
-    "biomarker": "",
+    "year": "2012",
+    "tx": "Regorafenib",
+    "biomarker": "KIT+",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, KIT and PDGFRβ)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include KIT, RET, VEGFR1/2/3, FGFR1/2, PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2021",
@@ -1900,14 +1900,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2021",
-    "tx": "Umbralisib*",
-    "biomarker": "",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include PI3Kδ and CK1ε among others)",
+    "year": "2018",
+    "tx": "Gilteritinib",
+    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include mutant and WT FLT3, AXL and ALK)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2022",
@@ -1965,7 +1965,7 @@
     "biomarker": "",
     "agentClass": "Gene therapy",
     "drugTarget": "Adenoviral vector-based gene therapy carrying IFNɑ2b",
-    "targetedTx": "N",
+    "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
@@ -2042,7 +2042,7 @@
   {
     "year": "2023",
     "tx": "Elacestrant",
-    "biomarker": "ESR1 Ligand-binding domain missense mutations and ER+/HER2-",
+    "biomarker": "ESR1 Ligand-binding domain missense mutations and\nER+/HER2-",
     "agentClass": "Hormone therapy",
     "drugTarget": "Selective estrogen receptor degrader (SERD)",
     "targetedTx": "Y",
@@ -2063,7 +2063,7 @@
     "year": "2023",
     "tx": "Enfortumab vedotin + Pembrolizumab",
     "biomarker": "",
-    "agentClass": "Antibody drug conjugate and immune checkpoint inhibitor combination",
+    "agentClass": "Antibody drug conjugate and immune checkpoint inhibitor combination ",
     "drugTarget": "Nectin-4-directed antibody and microtubule inhibitor conjugate + Anti-PD-1 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
@@ -2071,7 +2071,7 @@
   },
   {
     "year": "2023",
-    "tx": "Epcoritamab",
+    "tx": "Epcoritamab ",
     "biomarker": "",
     "agentClass": "Bispecific T-cell engager",
     "drugTarget": "Bispecific CD20-directed CD3 T-cell engager",
@@ -2120,14 +2120,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2023",
-    "tx": "Repotrectinib",
-    "biomarker": "ROS1 Fusions",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include ROS1 and NTRK1/2/3)",
+    "year": "2009",
+    "tx": "Pazopanib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include VEGFR1/2/3, PDGFRɑ/β, KIT, FGFR1/3 among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2023",
@@ -2164,14 +2164,14 @@
     "tx": "Eflornithine",
     "biomarker": "",
     "agentClass": "Small molecule inhibitor",
-    "drugTarget": "Ornithine decarboxylase inhibitor",
+    "drugTarget": "Ornithine decarboxylase inhibitor ",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
   {
     "year": "2024",
-    "tx": "Lifileucel",
+    "tx": "Lifileucel ",
     "biomarker": "",
     "agentClass": "Other Immunotherapy",
     "drugTarget": "Tumor-infiltrating lymphocyte therapy",
@@ -2192,7 +2192,7 @@
   {
     "year": "2024",
     "tx": "Tovorafenib",
-    "biomarker": "BRAF Fusions, BRAF Rearrangement, BRAF V600",
+    "biomarker": "BRAF Fusions, BRAF Rearrangement, BRAF V600 ",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "RAF inhibitor",
     "targetedTx": "Y",
@@ -2238,5 +2238,45 @@
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Lazertinib + Amivantamab",
+    "biomarker": "EGFR L858R, Exon 19 Deletions",
+    "agentClass": "Small molecule kinase inhibitor and monoclonal antibody combination",
+    "drugTarget": "EGFR tyrosine kinase inhibitor + EGFR-MET bispecific antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Inavolisib + Fulvestrant + Palbociclib",
+    "biomarker": "PIK3CA Oncogenic Mutations, HR+/HER2-",
+    "agentClass": "Small molecule inhibitor and hormone therapy combination",
+    "drugTarget": "α-specific PI3K inhibitor + selective estrogen receptor degrader + CDK4/6 inhibitor",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Adagrasib + Cetuximab",
+    "biomarker": "KRAS G12C",
+    "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
+    "drugTarget": "KRAS G12C inhibitor + Anti-EGFR antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Zolbetuximab",
+    "biomarker": "HER2- and CLDN18.2+",
+    "agentClass": "Monoclonal antibody",
+    "drugTarget": "CDLN18.2-directed cytolytic antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "N"
   }
 ]
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx
index ef19144ab..80cfeced0 100644
Binary files a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx and b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx differ
diff --git a/src/main/webapp/index.html b/src/main/webapp/index.html
index be05d1f38..7d47fb85a 100644
--- a/src/main/webapp/index.html
+++ b/src/main/webapp/index.html
@@ -14,7 +14,7 @@
     <meta name="twitter:site" content="@oncokb">
     <meta name="twitter:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
     <meta name="twitter:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
-    <meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240925">
+    <meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20241024">
     <meta name="twitter:url" content="https://www.oncokb.org/">
 
     <meta property="og:site_name" content="OncoKB™">
@@ -22,7 +22,7 @@
     <meta property="og:url" content="https://www.oncokb.org/">
     <meta property="og:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
     <meta property="og:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
-    <meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240925">
+    <meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20241024">
 
     <link rel="mask-icon" href="content/images/favicon/safari-pinned-tab.svg" color="#0968c3">
     <!-- Preload the customized fonts, so the html knows how to pain the page  -->