diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6be2429f06..6fdb7c123f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -106,6 +106,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
   ([#2792](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2792))
 - `opentelemetry-instrumentation-tornado` Handle http client exception and record exception info into span
   ([#2563](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2563))
+- `opentelemetry-instrumentation-sqlalchemy` Fixes engines from `sqlalchemy.engine_from_config` not being fully instrumented
+  ([#2816](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2816))
 - `opentelemetry-instrumentation` fix `http.host` new http semantic convention mapping to depend on `kind` of span
   ([#2814](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2814))
 - `opentelemetry-instrumentation` Fix the description of `http.server.duration` and `http.server.request.duration`
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
index 9889e18b5a..0b5e14b929 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/__init__.py
@@ -181,6 +181,13 @@ def _instrument(self, **kwargs):
                 tracer, connections_usage, enable_commenter, commenter_options
             ),
         )
+        _w(
+            "sqlalchemy.engine.create",
+            "create_engine",
+            _wrap_create_engine(
+                tracer, connections_usage, enable_commenter, commenter_options
+            ),
+        )
         _w(
             "sqlalchemy.engine.base",
             "Engine.connect",
@@ -224,6 +231,7 @@ def _instrument(self, **kwargs):
     def _uninstrument(self, **kwargs):
         unwrap(sqlalchemy, "create_engine")
         unwrap(sqlalchemy.engine, "create_engine")
+        unwrap(sqlalchemy.engine.create, "create_engine")
         unwrap(Engine, "connect")
         if parse_version(sqlalchemy.__version__).release >= (1, 4):
             unwrap(sqlalchemy.ext.asyncio, "create_async_engine")
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
index 957ae16237..458ab8a623 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/tests/test_sqlalchemy.py
@@ -182,6 +182,17 @@ def test_create_engine_wrapper(self):
             "opentelemetry.instrumentation.sqlalchemy",
         )
 
+    def test_instrument_engine_from_config(self):
+        SQLAlchemyInstrumentor().instrument()
+        from sqlalchemy import engine_from_config  # pylint: disable-all
+
+        engine = engine_from_config({"sqlalchemy.url": "sqlite:///:memory:"})
+        cnx = engine.connect()
+        cnx.execute(text("SELECT	1 + 1;")).fetchall()
+        spans = self.memory_exporter.get_finished_spans()
+
+        self.assertEqual(len(spans), 2)
+
     def test_create_engine_wrapper_enable_commenter(self):
         logging.getLogger("sqlalchemy.engine").setLevel(logging.INFO)
         SQLAlchemyInstrumentor().instrument(