diff --git a/Lib/test/test_dis.py b/Lib/test/test_dis.py
index a991c67fca46be..95f906dd982396 100644
--- a/Lib/test/test_dis.py
+++ b/Lib/test/test_dis.py
@@ -1335,6 +1335,32 @@ def test_call_specialize(self):
         got = self.get_disassembly(co, adaptive=True)
         self.do_disassembly_compare(got, call_quicken)
 
+    @cpython_only
+    @requires_specialization_ft
+    def test_compare_specialize(self):
+        compare_op_quicken = """\
+  0           RESUME_CHECK             0
+
+  1           LOAD_NAME                0 (a)
+              LOAD_NAME                1 (b)
+              %s
+              RETURN_VALUE
+"""
+        co_int = compile('a == b', "<int>", "eval")
+        self.code_quicken(lambda: exec(co_int, {}, {'a': 1, 'b': 2}))
+        got = self.get_disassembly(co_int, adaptive=True)
+        self.do_disassembly_compare(got, compare_op_quicken % "COMPARE_OP_INT          72 (==)")
+
+        co_float = compile('a == b', "<int>", "eval")
+        self.code_quicken(lambda: exec(co_float, {}, {'a': 1.0, 'b': 2.0}))
+        got = self.get_disassembly(co_float, adaptive=True)
+        self.do_disassembly_compare(got, compare_op_quicken % "COMPARE_OP_FLOAT        72 (==)")
+
+        co_unicode = compile('a == b', "<unicode>", "eval")
+        self.code_quicken(lambda: exec(co_unicode, {}, {'a': 'a', 'b': 'b'}))
+        got = self.get_disassembly(co_unicode, adaptive=True)
+        self.do_disassembly_compare(got, compare_op_quicken % "COMPARE_OP_STR          72 (==)")
+
     @cpython_only
     @requires_specialization
     def test_loop_quicken(self):
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index 8c52db6ab68436..16511bbe612961 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -2381,7 +2381,7 @@ dummy_func(
         };
 
         specializing op(_SPECIALIZE_COMPARE_OP, (counter/1, left, right -- left, right)) {
-            #if ENABLE_SPECIALIZATION
+            #if ENABLE_SPECIALIZATION_FT
             if (ADAPTIVE_COUNTER_TRIGGERS(counter)) {
                 next_instr = this_instr;
                 _Py_Specialize_CompareOp(left, right, next_instr, oparg);
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index d346875ea4455f..84b1127416963d 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -3216,7 +3216,7 @@
                 left = stack_pointer[-2];
                 uint16_t counter = read_u16(&this_instr[1].cache);
                 (void)counter;
-                #if ENABLE_SPECIALIZATION
+                #if ENABLE_SPECIALIZATION_FT
                 if (ADAPTIVE_COUNTER_TRIGGERS(counter)) {
                     next_instr = this_instr;
                     _PyFrame_SetStackPointer(frame, stack_pointer);
diff --git a/Python/specialize.c b/Python/specialize.c
index 86cb997ca2ced3..c4d5a7dc476b13 100644
--- a/Python/specialize.c
+++ b/Python/specialize.c
@@ -2382,8 +2382,9 @@ _Py_Specialize_CompareOp(_PyStackRef lhs_st, _PyStackRef rhs_st, _Py_CODEUNIT *i
 {
     PyObject *lhs = PyStackRef_AsPyObjectBorrow(lhs_st);
     PyObject *rhs = PyStackRef_AsPyObjectBorrow(rhs_st);
+    uint8_t specialized_op;
 
-    assert(ENABLE_SPECIALIZATION);
+    assert(ENABLE_SPECIALIZATION_FT);
     assert(_PyOpcode_Caches[COMPARE_OP] == INLINE_CACHE_ENTRIES_COMPARE_OP);
     // All of these specializations compute boolean values, so they're all valid
     // regardless of the fifth-lowest oparg bit.
@@ -2393,12 +2394,12 @@ _Py_Specialize_CompareOp(_PyStackRef lhs_st, _PyStackRef rhs_st, _Py_CODEUNIT *i
         goto failure;
     }
     if (PyFloat_CheckExact(lhs)) {
-        instr->op.code = COMPARE_OP_FLOAT;
+        specialized_op = COMPARE_OP_FLOAT;
         goto success;
     }
     if (PyLong_CheckExact(lhs)) {
         if (_PyLong_IsCompact((PyLongObject *)lhs) && _PyLong_IsCompact((PyLongObject *)rhs)) {
-            instr->op.code = COMPARE_OP_INT;
+            specialized_op = COMPARE_OP_INT;
             goto success;
         }
         else {
@@ -2413,18 +2414,19 @@ _Py_Specialize_CompareOp(_PyStackRef lhs_st, _PyStackRef rhs_st, _Py_CODEUNIT *i
             goto failure;
         }
         else {
-            instr->op.code = COMPARE_OP_STR;
+            specialized_op = COMPARE_OP_STR;
             goto success;
         }
     }
     SPECIALIZATION_FAIL(COMPARE_OP, compare_op_fail_kind(lhs, rhs));
 failure:
     STAT_INC(COMPARE_OP, failure);
-    instr->op.code = COMPARE_OP;
+    SET_OPCODE_OR_RETURN(instr, COMPARE_OP);
     cache->counter = adaptive_counter_backoff(cache->counter);
     return;
 success:
     STAT_INC(COMPARE_OP, success);
+    SET_OPCODE_OR_RETURN(instr, specialized_op);
     cache->counter = adaptive_counter_cooldown();
 }