diff --git a/backend/antigenapi/urls.py b/backend/antigenapi/urls.py
index 93d849b..756a9ec 100644
--- a/backend/antigenapi/urls.py
+++ b/backend/antigenapi/urls.py
@@ -4,6 +4,7 @@
 from antigenapi.views.dashboard import AuditLogLatestEvents, DashboardStats
 from antigenapi.views_old import (
     AntigenViewSet,
+    BlastAllView,
     CohortViewSet,
     ElisaPlateViewSet,
     GlobalFastaView,
@@ -29,4 +30,5 @@
     path("fasta/", GlobalFastaView.as_view(), name="fasta"),
     path("dashboard/stats", DashboardStats.as_view(), name="dashboard_stats"),
     path("dashboard/latest", AuditLogLatestEvents.as_view(), name="dashboard_latest"),
+    path("blast/all", BlastAllView.as_view(), name="blast_all"),
 ]
diff --git a/backend/antigenapi/views_old.py b/backend/antigenapi/views_old.py
index ffbc5f2..68adcde 100644
--- a/backend/antigenapi/views_old.py
+++ b/backend/antigenapi/views_old.py
@@ -4,9 +4,10 @@
 import math
 import os
 import re
+import subprocess
 import urllib.error
 import urllib.parse
-from tempfile import NamedTemporaryFile
+from tempfile import NamedTemporaryFile, TemporaryDirectory
 from wsgiref.util import FileWrapper
 
 import numpy as np
@@ -1053,19 +1054,24 @@ def search_sequencing_run_results(self, request, query):
         )
 
 
+def _get_entire_db_fasta():
+    fasta_data = ""
+    for sr in SequencingRunResults.objects.all():
+        airr_file = read_airr_file(
+            sr.airr_file, usecols=("sequence_id", "sequence_alignment_aa")
+        )
+        airr_file = airr_file[airr_file.sequence_alignment_aa.notna()]
+        if not airr_file.empty:
+            for _, row in airr_file.iterrows():
+                fasta_data += f"> {row.sequence_id}\n"
+                fasta_data += f"{row.sequence_alignment_aa.replace('.', '')}\n"
+    return fasta_data
+
+
 class GlobalFastaView(APIView):
     def get(self, request, format=None):
         """Download entire database as .fasta file."""
-        fasta_data = ""
-        for sr in SequencingRunResults.objects.all():
-            airr_file = read_airr_file(
-                sr.airr_file, usecols=("sequence_id", "sequence_alignment_aa")
-            )
-            airr_file = airr_file[airr_file.sequence_alignment_aa.notna()]
-            if not airr_file.empty:
-                for _, row in airr_file.iterrows():
-                    fasta_data += f"> {row.sequence_id}\n"
-                    fasta_data += f"{row.sequence_alignment_aa.replace('.', '')}\n"
+        fasta_data = _get_entire_db_fasta()
 
         fasta_filename = (
             f"antigenapp_database_{datetime.datetime.now().isoformat()}.fasta"
@@ -1078,3 +1084,74 @@ def get(self, request, format=None):
         )
         response["Content-Disposition"] = f'attachment; filename="{fasta_filename}"'
         return response
+
+
+class BlastAllView(APIView):
+    def get(self, request, format=None):
+        """Run all-vs-all BLAST on entire DB."""
+        fasta_data = _get_entire_db_fasta()
+
+        # Write the DB to disk as .fasta format
+        with TemporaryDirectory() as tmp_dir:
+            fasta_filename = os.path.join(tmp_dir, "antigen.fasta")
+            with open(fasta_filename, "w") as f:
+                f.write(fasta_data)
+
+            # Run makeblastdb
+            mkdb_proc = subprocess.run(
+                [
+                    "makeblastdb",
+                    "-in",
+                    "antigen.fasta",
+                    "-dbtype",
+                    "prot",
+                    "-out",
+                    "antigen.db",
+                ],
+                cwd=tmp_dir,
+            )
+
+            if mkdb_proc.returncode != 0:
+                raise Exception(
+                    f"makeblastdb returned exit code of " f"{mkdb_proc.returncode}"
+                )
+
+            # Run blastp
+            blastp_proc = subprocess.run(
+                [
+                    "blastp",
+                    "-db",
+                    "antigen.db",
+                    "-query",
+                    "antigen.fasta",
+                    "-html",
+                    "-out",
+                    "antigen.html",
+                    "-num_threads",
+                    "4",
+                ],
+                cwd=tmp_dir,
+            )
+
+            if blastp_proc.returncode != 0:
+                raise Exception(
+                    f"blastp returned exit code of " f"{blastp_proc.returncode}"
+                )
+
+            # Read in the results file
+            with open(os.path.join(tmp_dir, "antigen.html"), "r") as f:
+                results = f.read()
+
+        # blast_filename = (
+        #     f"antigenapp_database_blast_allvsall_"
+        #     f"{datetime.datetime.now().isoformat()}.tsv"
+        # )
+        # response = FileResponse(
+        #     results,
+        #     as_attachment=True,
+        #     content_type="text/tab-separated-values",
+        #     filename=blast_filename,
+        # )
+        # response["Content-Disposition"] = f'attachment; filename="{blast_filename}"'
+        response = HttpResponse(results)
+        return response
diff --git a/frontend/src/App.js b/frontend/src/App.js
index 4130fdf..2cccaeb 100644
--- a/frontend/src/App.js
+++ b/frontend/src/App.js
@@ -685,6 +685,14 @@ const App = () => {
                     onSetError={setError}
                     extraButton={
                       <>
+                        <a href="/api/blast/all" target="_blank">
+                          <button
+                            type="button"
+                            className="w-full sm:w-auto mr-2 inline-flex items-center justify-center rounded-md border border-transparent bg-indigo-600 px-4 py-2 text-sm font-medium text-white shadow-sm hover:bg-indigo-700 focus:outline-none focus:ring-2 focus:ring-indigo-500 focus:ring-offset-2 sm:w-auto"
+                          >
+                            BLAST all-vs-all
+                          </button>
+                        </a>
                         <a href="/api/fasta">
                           <button
                             type="button"