diff --git a/docs/conf.py b/docs/conf.py
index fc8a414ea..f98fe5ba7 100644
--- a/docs/conf.py
+++ b/docs/conf.py
@@ -112,6 +112,8 @@
     ("py:obj", "numpy._typing._array_like._ScalarType_co"),
     # https://github.com/sphinx-doc/sphinx/issues/10974
     ("py:class", "numpy.int64"),
+    # https://github.com/tox-dev/sphinx-autodoc-typehints/issues/498
+    ("py:class", "types.EllipsisType"),
 ]
 
 
diff --git a/docs/release-notes/1729.feature.md b/docs/release-notes/1729.feature.md
new file mode 100644
index 000000000..a7f55361b
--- /dev/null
+++ b/docs/release-notes/1729.feature.md
@@ -0,0 +1 @@
+Add support for ellipsis indexing of the {class}`~anndata.AnnData` object {user}`ilan-gold`
diff --git a/src/anndata/_core/anndata.py b/src/anndata/_core/anndata.py
index e972ba23c..7ef9f8ac4 100644
--- a/src/anndata/_core/anndata.py
+++ b/src/anndata/_core/anndata.py
@@ -52,9 +52,10 @@
     from os import PathLike
     from typing import Any, Literal
 
+    from ..compat import Index1D
     from ..typing import ArrayDataStructureType
     from .aligned_mapping import AxisArraysView, LayersView, PairwiseArraysView
-    from .index import Index, Index1D
+    from .index import Index
 
 
 # for backwards compat
diff --git a/src/anndata/_core/index.py b/src/anndata/_core/index.py
index 78f446d18..f1d72ce0d 100644
--- a/src/anndata/_core/index.py
+++ b/src/anndata/_core/index.py
@@ -26,14 +26,8 @@ def _normalize_indices(
     if isinstance(index, pd.Series):
         index: Index = index.values
     if isinstance(index, tuple):
-        if len(index) > 2:
-            raise ValueError("AnnData can only be sliced in rows and columns.")
-        # deal with pd.Series
         # TODO: The series should probably be aligned first
-        if isinstance(index[1], pd.Series):
-            index = index[0], index[1].values
-        if isinstance(index[0], pd.Series):
-            index = index[0].values, index[1]
+        index = tuple(i.values if isinstance(i, pd.Series) else i for i in index)
     ax0, ax1 = unpack_index(index)
     ax0 = _normalize_index(ax0, names0)
     ax1 = _normalize_index(ax1, names1)
@@ -107,8 +101,7 @@ def name_idx(i):
                     "are not valid obs/ var names or indices."
                 )
             return positions  # np.ndarray[int]
-    else:
-        raise IndexError(f"Unknown indexer {indexer!r} of type {type(indexer)}")
+    raise IndexError(f"Unknown indexer {indexer!r} of type {type(indexer)}")
 
 
 def _fix_slice_bounds(s: slice, length: int) -> slice:
@@ -132,13 +125,28 @@ def _fix_slice_bounds(s: slice, length: int) -> slice:
 
 def unpack_index(index: Index) -> tuple[Index1D, Index1D]:
     if not isinstance(index, tuple):
+        if index is Ellipsis:
+            index = slice(None)
         return index, slice(None)
-    elif len(index) == 2:
+    num_ellipsis = sum(i is Ellipsis for i in index)
+    if num_ellipsis > 1:
+        raise IndexError("an index can only have a single ellipsis ('...')")
+    # If index has Ellipsis, filter it out (and if not, error)
+    if len(index) > 2:
+        if not num_ellipsis:
+            raise IndexError("Received a length 3 index without an ellipsis")
+        index = tuple(i for i in index if i is not Ellipsis)
         return index
-    elif len(index) == 1:
-        return index[0], slice(None)
-    else:
-        raise IndexError("invalid number of indices")
+    # If index has Ellipsis, replace it with slice
+    if len(index) == 2:
+        index = tuple(slice(None) if i is Ellipsis else i for i in index)
+        return index
+    if len(index) == 1:
+        index = index[0]
+        if index is Ellipsis:
+            index = slice(None)
+        return index, slice(None)
+    raise IndexError("invalid number of indices")
 
 
 @singledispatch
diff --git a/src/anndata/compat/__init__.py b/src/anndata/compat/__init__.py
index 93c86141a..b5ec3d415 100644
--- a/src/anndata/compat/__init__.py
+++ b/src/anndata/compat/__init__.py
@@ -10,6 +10,7 @@
 from importlib.util import find_spec
 from inspect import Parameter, signature
 from pathlib import Path
+from types import EllipsisType
 from typing import TYPE_CHECKING, TypeVar
 from warnings import warn
 
@@ -47,7 +48,17 @@ class Empty:
 
 
 Index1D = slice | int | str | np.int64 | np.ndarray
-Index = Index1D | tuple[Index1D, Index1D] | scipy.sparse.spmatrix | SpArray
+IndexRest = Index1D | EllipsisType
+Index = (
+    IndexRest
+    | tuple[Index1D, IndexRest]
+    | tuple[IndexRest, Index1D]
+    | tuple[Index1D, Index1D, EllipsisType]
+    | tuple[EllipsisType, Index1D, Index1D]
+    | tuple[Index1D, EllipsisType, Index1D]
+    | scipy.sparse.spmatrix
+    | SpArray
+)
 H5Group = h5py.Group
 H5Array = h5py.Dataset
 H5File = h5py.File
diff --git a/tests/conftest.py b/tests/conftest.py
index 65eff92b1..13fabdb93 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -1,6 +1,7 @@
 from __future__ import annotations
 
 from functools import partial
+from typing import TYPE_CHECKING
 
 import joblib
 import pytest
@@ -10,12 +11,63 @@
 import anndata as ad
 from anndata.tests.helpers import subset_func  # noqa: F401
 
+if TYPE_CHECKING:
+    from types import EllipsisType
+
 
 @pytest.fixture
 def backing_h5ad(tmp_path):
     return tmp_path / "test.h5ad"
 
 
+@pytest.fixture(
+    params=[
+        pytest.param((..., (slice(None), slice(None))), id="ellipsis"),
+        pytest.param(((...,), (slice(None), slice(None))), id="ellipsis_tuple"),
+        pytest.param(
+            ((..., slice(0, 10)), (slice(None), slice(0, 10))), id="obs-ellipsis"
+        ),
+        pytest.param(
+            ((slice(0, 10), ...), (slice(0, 10), slice(None))), id="var-ellipsis"
+        ),
+        pytest.param(
+            ((slice(0, 10), slice(0, 10), ...), (slice(0, 10), slice(0, 10))),
+            id="obs-var-ellipsis",
+        ),
+        pytest.param(
+            ((..., slice(0, 10), slice(0, 10)), (slice(0, 10), slice(0, 10))),
+            id="ellipsis-obs-var",
+        ),
+        pytest.param(
+            ((slice(0, 10), ..., slice(0, 10)), (slice(0, 10), slice(0, 10))),
+            id="obs-ellipsis-var",
+        ),
+    ]
+)
+def ellipsis_index_with_equivalent(
+    request,
+) -> tuple[tuple[EllipsisType | slice, ...] | EllipsisType, tuple[slice, slice]]:
+    return request.param
+
+
+@pytest.fixture
+def ellipsis_index(
+    ellipsis_index_with_equivalent: tuple[
+        tuple[EllipsisType | slice, ...] | EllipsisType, tuple[slice, slice]
+    ],
+) -> tuple[EllipsisType | slice, ...] | EllipsisType:
+    return ellipsis_index_with_equivalent[0]
+
+
+@pytest.fixture
+def equivalent_ellipsis_index(
+    ellipsis_index_with_equivalent: tuple[
+        tuple[EllipsisType | slice, ...] | EllipsisType, tuple[slice, slice]
+    ],
+) -> tuple[slice, slice]:
+    return ellipsis_index_with_equivalent[1]
+
+
 #####################
 # Dask tokenization #
 #####################
diff --git a/tests/test_backed_sparse.py b/tests/test_backed_sparse.py
index 5f78ddb52..2778c76bb 100644
--- a/tests/test_backed_sparse.py
+++ b/tests/test_backed_sparse.py
@@ -20,6 +20,7 @@
 if TYPE_CHECKING:
     from collections.abc import Callable, Generator, Sequence
     from pathlib import Path
+    from types import EllipsisType
 
     from _pytest.mark import ParameterSet
     from numpy.typing import ArrayLike, NDArray
@@ -127,6 +128,17 @@ def test_backed_indexing(
     assert_equal(csr_mem[:, var_idx].X, dense_disk[:, var_idx].X)
 
 
+def test_backed_ellipsis_indexing(
+    ondisk_equivalent_adata: tuple[AnnData, AnnData, AnnData, AnnData],
+    ellipsis_index: tuple[EllipsisType | slice, ...] | EllipsisType,
+    equivalent_ellipsis_index: tuple[slice, slice],
+):
+    csr_mem, csr_disk, csc_disk, _ = ondisk_equivalent_adata
+
+    assert_equal(csr_mem.X[equivalent_ellipsis_index], csr_disk.X[ellipsis_index])
+    assert_equal(csr_mem.X[equivalent_ellipsis_index], csc_disk.X[ellipsis_index])
+
+
 def make_randomized_mask(size: int) -> np.ndarray:
     randomized_mask = np.zeros(size, dtype=bool)
     inds = np.random.choice(size, 20, replace=False)
diff --git a/tests/test_views.py b/tests/test_views.py
index 4e4f4ab75..6e57e08c7 100644
--- a/tests/test_views.py
+++ b/tests/test_views.py
@@ -3,6 +3,7 @@
 from contextlib import ExitStack
 from copy import deepcopy
 from operator import mul
+from typing import TYPE_CHECKING
 
 import joblib
 import numpy as np
@@ -35,6 +36,9 @@
 )
 from anndata.utils import asarray
 
+if TYPE_CHECKING:
+    from types import EllipsisType
+
 IGNORE_SPARSE_EFFICIENCY_WARNING = pytest.mark.filterwarnings(
     "ignore:Changing the sparsity structure:scipy.sparse.SparseEfficiencyWarning"
 )
@@ -786,6 +790,30 @@ def test_dataframe_view_index_setting():
     assert a2.obs.index.values.tolist() == ["a", "b"]
 
 
+def test_ellipsis_index(
+    ellipsis_index: tuple[EllipsisType | slice, ...] | EllipsisType,
+    equivalent_ellipsis_index: tuple[slice, slice],
+    matrix_type,
+):
+    adata = gen_adata((10, 10), X_type=matrix_type, **GEN_ADATA_DASK_ARGS)
+    subset_ellipsis = adata[ellipsis_index]
+    subset = adata[equivalent_ellipsis_index]
+    assert_equal(subset_ellipsis, subset)
+
+
+@pytest.mark.parametrize(
+    ("index", "expected_error"),
+    [
+        ((..., 0, ...), r"only have a single ellipsis"),
+        ((0, 0, 0), r"Received a length 3 index"),
+    ],
+    ids=["ellipsis-int-ellipsis", "int-int-int"],
+)
+def test_index_3d_errors(index: tuple[int | EllipsisType, ...], expected_error: str):
+    with pytest.raises(IndexError, match=expected_error):
+        gen_adata((10, 10))[index]
+
+
 # @pytest.mark.parametrize("dim", ["obs", "var"])
 # @pytest.mark.parametrize(
 #     ("idx", "pat"),