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KEGG_2015__enrichment.txt
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Term Overlap P-value Adjusted P-value Z-score Combined Score Genes
oxidative phosphorylation 92/126 0.00000000000567436781880735 0.0000000009986887361100936 -1.9312970516200711 40.025316312719504 COX7B;NDUFA13;NDUFA11;NDUFA12;COX4I1;NDUFA10;ATP5C1;ATP5G3;ATP5G2;COX6A1;ATP5G1;COX7C;UQCRFS1;ATP6V1E1;COX8A;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6V1G2;ATP6AP1;NDUFC2;NDUFC1;SDHC;ATP5F1;SDHB;ATP5J2;COX6B1;NDUFS8;NDUFS7;PPA2;NDUFS6;PPA1;NDUFS5;ATP6V1B2;NDUFS3;UQCRC1;NDUFS2;NDUFS1;UQCRC2;ATP6V0D1;ATP6V0C;ND2;ATP6V1A;NDUFB9;NDUFB8;NDUFB10;NDUFB6;UQCRB;COX15;NDUFB11;NDUFB5;NDUFB4;ATP5A1;ATP6;NDUFB3;NDUFB2;ATP5J;NDUFB1;ATP5I;COX7A2;ATP5H;ATP5O;COX5B;COX5A;UQCRH;ATP5L;ATP5B;ATP5E;ATP5D;COX3;ATP6V1H;COX1;CYC1;NDUFV3;NDUFV2;ATP6V1D;NDUFV1;ATP6V1C1;ATP6V0A1;ATP6V1F;LHPP;NDUFA9;NDUFA8;NDUFA6;NDUFA5;NDUFA4;NDUFA3;NDUFA2;NDUFA1;COX6C;UQCRQ;NDUFAB1
ribosome 60/71 0.0000000007071739464149551 0.00000006223130728451605 -1.8045737792300378 29.942223745708105 RPL30;RPL3;RPL32;RPL31;RPL34;RPL10A;RPL8;RPL9;RPL6;RPL7;RPS16;RPL18A;RPL36AL;RPS18;RPL35;RPL38;RPL37;RPS11;RPL39;RPS10;RPS13;RPS12;RPS9;RPL21;RPS7;RPS8;RPS5;RPS6;RPL13A;RPS3A;RPL37A;RPL24;RPL27;RPL26;RPL29;RPL28;RPL12;RPL11;RPL36A;RPS15A;RPL14;RPS3;RPL13;RPS2;RPL18;RPL19;RPL41;RPL35A;RPL23A;RPS26;RPS25;RPS28;RPS27;RPS29;RPL27A;RPS20;FAU;RPS21;RPS24;RPS23
pathogenic escherichia coli infection epec 30/48 0.0006521089824757092 0.019742472676166203 -1.757365348956981 6.8976291029335846 ITGB1;ROCK2;ARPC5L;WASL;ACTB;ACTG1;CDC42;TUBB8;TUBA1C;TUBA1B;TUBA3D;TUBA1A;YWHAQ;TUBB3;NCK2;FYN;TUBB;PRKCA;ARPC5;YWHAZ;RHOA;TUBA4A;TUBB2B;KRT18;TUBB2A;CTTN;NCL;CTNNB1;ARHGEF2;EZR
proteasome 20/22 0.00019680323596800862 0.011545789843456507 -1.4751206844750964 6.581154201543634 PSMD11;PSMA7;PSMA5;PSMB6;PSMA6;PSMB7;PSMA3;PSMB4;PSMD6;PSMA4;PSMB5;PSMA1;PSMB2;PSMC3;PSMA2;PSMB3;PSMD2;PSMB1;PSMC2;PSMD1
pathogenic escherichia coli infection ehec 30/48 0.0006521089824757092 0.019742472676166203 -1.572908678590849 6.173639809243008 ITGB1;ROCK2;ARPC5L;WASL;ACTB;ACTG1;CDC42;TUBB8;TUBA1C;TUBA1B;TUBA3D;TUBA1A;YWHAQ;TUBB3;NCK2;FYN;TUBB;PRKCA;ARPC5;YWHAZ;RHOA;TUBA4A;TUBB2B;KRT18;TUBB2A;CTTN;NCL;CTNNB1;ARHGEF2;EZR
cholera infection 27/41 0.0006730388412329387 0.019742472676166203 -1.449844790264336 5.690616140803814 ARF3;ATP6V1A;ARF4;AK1;ADCY3;ACTG1;SEC61A2;SEC61G;ATP6V1H;PLCG1;SEC61B;ATP6V1E1;ATP6V1D;ATP6V1C1;ATP6V0A1;ATP6V1F;TRIM23;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6V1G2;PRKCA;ADCY9;GNAS;ATP6V0D1;ATP6V0C;ARF5
epithelial cell signaling in helicobacter pylori infection 33/65 0.004753590211761604 0.11951883961000605 -1.4964020720373319 3.178778888625635 ATP6V1A;F11R;CDC42;MAPK9;MAPK8;PAK1;PTPRZ1;ATP6V1H;PLCG1;RAC1;ATP6V1E1;ATP6V1D;ATP6V1C1;ATP6V0A1;ATP6V1F;JAM3;MAP2K4;ATP6V0B;ATP6V1G1;JUN;ATP6V0E1;ATP6V1G2;ATP6AP1;ADAM10;PTPN11;MAPK10;NFKBIA;TJP1;MAPK11;ADAM17;ATP6V1B2;ATP6V0D1;ATP6V0C
long term potentiation 33/67 0.006723945350420274 0.13149048685266312 -1.3439102887096877 2.7265531111951926 CAMK2B;GRIA1;GRIA2;CAMK2D;CAMK2A;ADCY1;CACNA1C;PPP1CB;RAP1B;PPP1CC;PPP3CA;GRIN2A;GRM5;PPP3CB;RPS6KA2;MAPK1;CAMK2G;HRAS;PRKACB;MAPK3;CREBBP;MAP2K1;MAP2K2;PRKCA;GRIN2C;PPP1R1A;GNAQ;CALM3;KRAS;CALM1;PLCB1;CALM2;ATF4
renal cell carcinoma 33/69 0.00933301654285633 0.1642610911542714 -1.3842173285411619 2.500309127546321 FH;EPAS1;SLC2A1;PIK3R2;PIK3CB;PIK3R1;HIF1A;CRKL;CDC42;RAP1B;PAK1;AKT3;PAK7;MAPK1;PAK6;TCEB2;TCEB1;RAC1;PAK3;HRAS;PAK2;MAPK3;EGLN1;ARNT2;CREBBP;JUN;MAP2K1;MAP2K2;PTPN11;PGF;RBX1;GRB2;KRAS
regulation of actin cytoskeleton 77/201 0.012110367109796913 0.19376587375675058 -1.4544351591156284 2.386880353708041 CHRM2;CYFIP2;ITGB1;CHRM3;CYFIP1;NCKAP1;CHRM1;ARPC1A;ITGB2;ARPC5L;ITGAE;PIK3CB;WASL;FGF1;CRKL;MYLK;PPP1CB;PPP1CC;FGF9;CFL2;TMSB4X;CFL1;PIP4K2A;ITGAV;PIP4K2B;PIP4K2C;RAC1;HRAS;MAP2K1;ARHGEF12;MAP2K2;ACTN1;F2R;RHOA;TIAM1;MRAS;ARHGEF4;MYH9;ARHGEF7;EZR;PFN1;ARHGEF6;PFN2;ROCK2;PDGFA;PIK3R2;PIK3R1;CDC42;GNA13;PAK1;GNA12;PAK7;MAPK1;PAK6;PIP5K1C;PAK3;WASF1;MYH10;PAK2;WASF2;MAPK3;GSN;RDX;ARPC4;ARPC5;BAIAP2;SSH2;PTK2;FGF14;ABI2;APC;ARPC2;ARPC3;KRAS;FGF13;FGFR3;FGFR2
gap junction 39/90 0.016645843839500768 0.22368937139880846 -1.2236573585901245 1.8324231309597108 GUCY1B3;ADCY3;PDGFA;ADCY2;ADCY1;HTR2A;GNAI1;GNAI2;TUBB8;TUBA1C;GJA1;GRM5;TUBA1B;TUBA3D;TUBA1A;TUBB3;GNA11;MAPK1;HRAS;PRKACB;MAPK3;GUCY1A3;MAP3K2;GUCY1A2;MAP2K1;MAP2K2;TUBB;CSNK1D;PRKCA;TUBA4A;TJP1;TUBB2B;ADCY9;TUBB2A;GNAQ;GNAS;GRB2;KRAS;PLCB1
long term depression 32/73 0.025287972129012504 0.2571714877401377 -0.9012876354496123 1.2239595588098044 GRIA1;GRIA2;GUCY1B3;CACNA1A;PPP2R2A;GNAI1;GNAI2;GNA13;PPP2CA;PPP2CB;GRM5;PPP2R1A;GNA11;GNA12;MAPK1;HRAS;GRIA3;MAPK3;GUCY1A3;GUCY1A2;MAP2K1;PLA2G12A;PLA2G2D;MAP2K2;PRKCA;GNAO1;PPP2R2C;PPP2R2B;GNAQ;GNAS;KRAS;PLCB1
amyotrophic lateral sclerosis 14/19 0.006608799988093523 0.13149048685266312 -0.5533391610883072 1.1226259847002138 GPX1;SSR4;SLC1A2;SOD1;PPP3CA;KARS;CAT;BAX;NEFL;NEFM;RAC1;NEFH;RAB5A;BCL2L1
tight junction 51/131 0.029961264789735157 0.2571714877401377 -0.8202247770028755 1.1138752121951587 PTEN;PPP2R2A;F11R;ACTB;ACTG1;PPP2R4;PPP2R1A;AKT3;HRAS;SPTAN1;MAGI1;PRKCI;CSNK2A1;ACTN1;PRKCE;MAGI2;PRKCA;ASH1L;RHOA;CLDN11;CLDN10;MRAS;CTTN;CLDN14;CSNK2B;EXOC4;MYH9;MLLT4;PRKCZ;GNAI1;GNAI2;CDC42;PPP2CA;PPP2CB;PARD6B;EPB41L1;EPB41L2;EPB41L3;CTNNA1;CTNNA2;MPDZ;MYH10;JAM3;PPP2R3A;TJP1;PPP2R2C;VAPA;PPP2R2B;RAB13;CTNNB1;KRAS
ubiquitin mediated proteolysis 21/39 0.013838688361875419 0.20296742930750614 -0.6907858790840165 1.101602983151436 UBE2D4;FBXW11;FBXW7;CUL3;UBE2D2;UBE2E3;UBE2D3;UBE2E1;UBE2E2;WWP1;ANAPC11;RBX1;CDC16;CDC27;ANAPC4;TCEB2;ANAPC5;TCEB1;UBA1;BTRC;SKP1
axon guidance 49/126 0.03334107205133142 0.2571714877401377 -0.6244897633833064 0.8480646856877945 ITGB1;GSK3B;ROBO1;PPP3CA;PPP3CB;CFL2;DPYSL2;CFL1;NCK2;RAC1;HRAS;EPHA4;ARHGEF12;SEMA6A;UNC5A;SEMA6D;UNC5D;RHOA;RASA1;EPHA3;NGEF;NFAT5;ROCK2;SEMA3B;SEMA3E;GNAI1;GNAI2;CDC42;EFNB2;ABLIM1;PAK1;EFNB3;PAK7;MAPK1;PAK6;PLXNA1;FYN;SLIT2;SRGAP3;LRRC4C;PAK3;PAK2;MAPK3;SEMA4D;SEMA4C;L1CAM;PTK2;CDK5;KRAS
phosphatidylinositol signaling system 31/72 0.03240895028773543 0.2571714877401377 -0.5800724272381018 0.7877454035701926 CDS1;INPP1;PTEN;PIK3R2;PIK3CB;PIK3R1;PIK3C2A;INPP5A;IMPA1;PIP4K2A;PIP4K2B;PIP4K2C;PIP5K1C;PLCG1;CDIPT;ITPK1;PRKCA;SYNJ2;DGKZ;INPP4A;ITPKB;SYNJ1;DGKQ;PI4KA;CALM3;PIK3C3;PI4KB;CALM1;PLCB1;CALM2;CDS2
neurodegenerative diseases 20/38 0.01906443506239845 0.22368937139880846 -0.5252725463666833 0.7865940226350759 APP;PRNP;CREBBP;HSPA5;APLP1;PARK7;GFAP;SOD1;PINK1;UCHL1;VAPB;BAX;APBA1;GRB2;APOE;MAPT;GAPDH;NEFH;BCL2L1;SNCA
erbb signaling pathway 35/85 0.03775780655748232 0.27689058142153705 -0.556433790732015 0.7145349171808564 CAMK2B;GSK3B;CAMK2D;CDKN1B;SHC3;CAMK2A;PIK3R2;PIK3CB;PIK3R1;ELK1;CRKL;MAPK9;MAPK8;PAK1;ERBB4;AKT3;NCK2;PAK7;MAPK1;PAK6;PLCG1;PAK3;CAMK2G;HRAS;PAK2;MAPK3;MAP2K4;JUN;MAP2K1;MAP2K2;PRKCA;PTK2;MAPK10;GRB2;KRAS
aminoacyl trna biosynthesis 20/38 0.01906443506239845 0.22368937139880846 -0.3743013667887609 0.5605151455500721 CARS;YARS;DARS;MTFMT;WARS;SARS;EPRS;HARS2;NARS;KARS;QARS;LARS;MARS;RARS;GARS;HARS;IARS;VARS2;AARS;FARSB
gnrh signaling pathway 38/96 0.047031969783498315 0.33110506727582817 -0.46751581959426297 0.5167543660653237 CAMK2B;CAMK2D;CAMK2A;ADCY3;ADCY2;ADCY1;CACNA1C;ELK1;CDC42;MAPK9;MAPK8;GNA11;MAPK1;CAMK2G;HRAS;PRKACB;MAP3K4;MAPK3;MAP3K2;MAP2K4;JUN;MAP2K1;PLA2G12A;PLA2G2D;MAP2K2;PRKCA;MAPK10;MAPK11;ADCY9;GNAQ;GNAS;CALM3;GRB2;KRAS;CALM1;PLCB1;CALM2;ATF4
apoptosis 22/81 0.599285629621707 0.9999999999717443 4.754537917049604 -0.00000000013434294483480935 DFFA;PIK3R2;CFLAR;PIK3CB;PIK3R1;NFKBIA;PPP3CA;PPP3CB;PRKAR1B;CASP10;PRKAR1A;PRKAR2B;PRKAR2A;AKT3;CAPN2;BAX;CYCS;CAPN1;PRKACB;BIRC2;BCL2L1;BIRC3
cell cycle 26/104 0.7410082054136558 0.9999999999717443 5.486279609603206 -0.00000000015501884132593684 YWHAE;GSK3B;CDKN1B;CCNH;YWHAB;ANAPC11;CCND3;CCND2;CCND1;YWHAQ;CDC27;BUB3;YWHAG;SKP1;YWHAH;CDKN2D;SMAD2;CREBBP;YWHAZ;CDC25B;RBX1;TFDP1;CDC16;MDM2;ANAPC4;ANAPC5
small cell lung cancer 21/85 0.7419167033277702 0.9999999999717443 5.650981283510195 -0.00000000015967260753369857 ITGB1;PIAS4;CDKN1B;MAX;PTEN;PIK3R2;PIK3CB;PIK3R1;PIAS2;PTK2;PIAS1;NFKBIA;RXRB;RXRA;CCND1;AKT3;CYCS;ITGAV;BIRC2;BCL2L1;BIRC3
melanoma 18/71 0.6961823541685862 0.9999999999717443 6.0251407187032635 -0.00000000017024475591878454 MAP2K1;MAP2K2;PTEN;PDGFA;PIK3R2;PIK3CB;PIK3R1;FGF1;FGF14;CCND1;FGF9;AKT3;MDM2;MAPK1;KRAS;FGF13;HRAS;MAPK3
b cell receptor signaling pathway 16/62 0.6666973665947505 0.9999999999717443 6.27596069294061 -0.00000000017733185766249004 GSK3B;NFAT5;JUN;CD81;PIK3R2;BCL10;PIK3CB;PIK3R1;LILRB3;NFKBIA;PPP3CA;PPP3CB;AKT3;KRAS;RAC1;HRAS
tryptophan metabolism 15/57 0.6387848285574219 0.9999999999717443 6.428951753626245 -0.00000000018165473193218632 ECHS1;WARS;MAOB;PRMT2;MAOA;HSD17B4;ACAT1;ALDH2;AFMID;CAT;LNX1;WBSCR22;ALDH7A1;LCMT1;ALDH9A1
acute myeloid leukemia 14/52 0.6079690453545595 0.9999999999717443 6.597028599411817 -0.0000000001864038660889272 TCF7L2;MAP2K1;MAP2K2;STAT3;PIK3CB;CCND1;AKT3;MAPK1;GRB2;KRAS;HRAS;MAPK3;PPARD;RUNX1T1
glycan structures biosynthesis 1 24/106 0.8624359614127401 0.9999999999717443 6.728625674140855 -0.00000000019012223764452016 GALNT11;ALG8;RPN2;RPN1;B3GALT6;HS6ST1;DDOST;HS6ST3;EXTL2;GANAB;WBSCR17;CHSY1;DAD1;MAN1A2;MGAT5;MGAT4B;MAN1C1;MGAT3;CHST1;B3GNT1;OGT;CHST2;GALNT9;B4GALT5
lysine degradation 13/47 0.5738307543354623 0.9999999999717443 6.936856929789909 -0.00000000019600596400838588 ECHS1;SHMT2;SETD7;HSD17B4;ACAT1;SPCS3;SPCS1;ALDH2;RDH11;NSD1;ALDH7A1;AASDHPPT;ALDH9A1
natural killer cell mediated cytotoxicity 28/129 0.9174175749374408 0.9999999999717443 7.176842505225891 -0.00000000020278693189305314 NFAT5;SHC3;ITGB2;PIK3R2;PIK3CB;PIK3R1;PPP3CA;PAK1;PPP3CB;MAPK1;FYN;PLCG1;RAC1;HRAS;MAPK3;MAP2K1;MAP2K2;IFNGR1;IFNGR2;HLA-B;HLA-C;PRKCA;PTPN11;HLA-A;HLA-G;HLA-E;GRB2;KRAS
jak stat signaling pathway 30/148 0.9649988873216578 0.9999999999717443 7.597777256803861 -0.00000000021468075103949604 PIK3R2;PIK3CB;PIK3R1;CSF2RA;CCND3;SPRED1;CCND2;CCND1;AKT3;SOCS7;JAK1;IL10;PIAS4;CREBBP;IFNGR1;IL11RA;STAT1;IFNGR2;STAT2;STAT3;LIFR;PTPN11;TYK2;PIAS2;PIAS1;LEP;SPRY2;GRB2;IL6ST;BCL2L1
toll like receptor signaling pathway 19/99 0.9567839882918044 0.9999999999717443 7.831563825860196 -0.00000000022128656146688335 MAP2K4;JUN;MAP2K1;MAP2K2;STAT1;PIK3R2;PIK3CB;PIK3R1;MAPK10;NFKBIA;MAPK11;MAPK9;MAPK8;TOLLIP;AKT3;SPP1;MAPK1;RAC1;MAPK3
neuroactive ligand receptor interaction 30/238 0.999999135497056 0.9999999999717443 8.284781042881882 -0.00000000023409254527578163 CHRM2;GABRB3;GRIA1;CHRM3;GABRB2;GRIA2;ADCYAP1R1;GABRB1;CHRM1;THRB;THRA;GRIK5;GRIK2;HTR2A;NR3C1;MCHR1;GRM3;GRIN2A;GRM5;ADORA1;GRIA3;GABRA2;GABBR2;GABRA1;GABBR1;F2R;GRIN2C;SSTR2;GABRG2;LEP
cell communication 13/137 0.9999968087568795 0.9999999999717443 8.392585318534506 -0.00000000023713863389882583 KRT10;ACTB;ACTG1;GJC1;GJA1;GJC2;KRT18;GJB6;SPP1;GJB7;TNR;VIM;INA
cytokine cytokine receptor interaction 18/247 0.9999999999717444 0.9999999999717443 8.541350249093332 -0.0000000002413420957721135 IL10;BMPR2;XCR1;TNFSF14;IFNGR1;IL11RA;TNFSF15;IFNGR2;TNFRSF9;IL18;LIFR;ACVR1B;CSF2RA;CXCL14;KITLG;LEP;CCR6;IL6ST
starch and sucrose metabolism 15/83 0.9630782956996035 0.9999999999717443 8.61575006011658 -0.0000000002434443168254307 DDX18;GPI;PYGB;DDX47;AGL;SMARCA5;DDX51;DDX41;SMARCA2;HK1;DDX19A;UGP2;RUVBL2;GUSB;PGM1
bladder cancer 11/40 0.5829565237934388 0.9999999999717443 8.766687101029861 -0.0000000002477091532647886 MAP2K1;MAP2K2;CCND1;DAPK1;MDM2;MAPK1;KRAS;FGFR3;HRAS;PGF;MAPK3
ecm receptor interaction 9/87 0.99969378815555 0.9999999999717443 8.80000659735337 -0.00000000024865061999291405 ITGB1;SV2B;SV2A;SDC3;DAG1;SPP1;TNR;ITGAV;CD47
hematopoietic cell lineage 6/88 0.9999923208938648 0.9999999999717443 8.843329608147911 -0.00000000024987474333587404 KITLG;TFRC;IL11RA;CD9;CD59;CSF2RA
glycine serine and threonine metabolism 11/44 0.6899801595043243 0.9999999999717443 8.992009305875243 -0.0000000002540757968931951 GATM;CHKB;MAOB;MAOA;PSAT1;RDH11;SHMT2;SARS;GARS;PHGDH;DLD
folate biosynthesis 11/41 0.6112389536119787 0.9999999999717443 8.99692055615796 -0.00000000025421456786049247 DHFR;QDPR;DDX18;DDX19A;ALPP;DDX47;RUVBL2;SMARCA5;DDX51;DDX41;SMARCA2
tyrosine metabolism 12/53 0.7968797782308118 0.9999999999717443 9.008356964506245 -0.00000000025453771193940127 SH3GLB1;ADH4;GOT1;MAOB;PRMT2;MAOA;GOT2;WBSCR22;MIF;COMT;LCMT1;ADH5
n glycan biosynthesis 11/41 0.6112389536119787 0.9999999999717443 9.23854149978613 -0.00000000026104174426902905 ALG8;GANAB;RPN2;DAD1;MAN1A2;MGAT5;MGAT4B;RPN1;MAN1C1;MGAT3;DDOST
type i diabetes mellitus 11/44 0.6899801595043243 0.9999999999717443 9.326099446332497 -0.0000000002635157580613151 PTPRN2;GAD1;HLA-B;CPE;GAD2;HLA-C;HLA-A;HLA-G;HLA-DPA1;HLA-E;HSPD1
metabolism of xenobiotics by cytochrome p450 11/70 0.9806046808333936 0.9999999999717443 10.007866114764722 -0.0000000002827795737097216 ADH4;GSTM3;GSTM2;CYP2B6;GSTA4;AKR1C1;GSTP1;MGST3;EPHX1;MGST1;ADH5
hedgehog signaling pathway 10/57 0.9451219301403918 0.9999999999717443 10.482728069299608 -0.00000000029619714540127666 GSK3B;CSNK1A1;FBXW11;STK36;BMP8B;CSNK1D;CSNK1E;BTRC;PRKACB;CSNK1G2
notch signaling pathway 10/43 0.7579395159923522 0.9999999999717443 10.549124461801052 -0.000000000298073224013052 NCOR2;ADAM17;CREBBP;NUMBL;SNW1;CTBP2;CTBP1;DTX3;DTX4;RBPJ
complement and coagulation cascades 4/69 0.9999800854014634 0.9999999999717443 10.747398748432525 -0.0000000003036756089378993 F2R;CD59;A2M;F3
glycan structures biosynthesis 2 8/60 0.9902371076864667 0.9999999999717443 11.821542918074647 -0.00000000033402633774571793 UGCG;FUT9;ST3GAL5;B3GNT1;B4GALNT1;B4GALT6;PIGG;PIGX
sphingolipid metabolism 9/36 0.6827303512228053 0.9999999999717443 11.866425677298096 -0.0000000003352945329208511 UGCG;ASAH1;SPTLC1;CERK;SPHK2;PPAP2B;PPAP2A;DEGS1;B4GALT6
basal cell carcinoma 6/55 0.9962129943281112 0.9999999999717443 12.019777295468518 -0.00000000033962759500587953 GSK3B;TCF7L2;FZD3;APC;STK36;CTNNB1
androgen and estrogen metabolism 7/54 0.9890207151131093 0.9999999999717443 12.117064358211588 -0.00000000034237651208914956 PRMT2;SRD5A1;AKR1D1;WBSCR22;HSD17B12;HSD17B7;LCMT1
taste transduction 8/49 0.9533686807517774 0.9999999999717443 12.173163671264996 -0.0000000003439616391930431 GNG3;KCNB1;PDE1A;GNB1;CACNA1B;GNAS;CACNA1A;PRKACB
arachidonic acid metabolism 7/51 0.9825969710401168 0.9999999999717443 12.575401900859179 -0.0000000003553271744420196 CBR1;PLA2G12A;PLA2G2D;CYP2B6;GPX1;GPX4;PTGDS
abc transporters general 8/44 0.911713887666622 0.9999999999717443 12.67969515624416 -0.00000000035827405662053457 ABCA2;ABCD3;ABCC8;ABCA3;ABCC5;ABCB9;ABCC10;ABCG1
porphyrin and chlorophyll metabolism 7/41 0.9278584703221741 0.9999999999717443 13.788709670081762 -0.00000000038961007249690844 COX15;UROD;FTH1;BLVRB;EPRS;GUSB;BLVRA
aminosugars metabolism 7/29 0.7062376021540098 0.9999999999717443 13.824097608179416 -0.00000000039060998455957657 MTMR1;CMAS;CYB5R3;GNPDA1;PHPT1;HK1;LHPP
limonene and pinene degradation 6/24 0.6732264292646165 0.9999999999717443 14.06067773619095 -0.00000000039729472903758214 SH3GLB1;DHRS7;ECHS1;ALDH2;ALDH7A1;ALDH9A1
galactose metabolism 7/32 0.7852064541423942 0.9999999999717443 14.64515651235389 -0.0000000004138096041638489 UGP2;RDH11;AKR1B1;PFKM;PFKP;PGM1;HK1
basal transcription factors 7/33 0.8076785286406082 0.9999999999717443 15.494693496825088 -0.0000000004378138927469057 GTF2A1;TAF13;TAF10;TAF7;GTF2H1;TAF6;GTF2I
selenoamino acid metabolism 6/26 0.7360341095319246 0.9999999999717443 16.12481904221695 -0.00000000045561855070956926 PRMT2;MARS;WBSCR22;MAT2B;LCMT1;PAPSS1
regulation of autophagy 6/29 0.8132674723710985 0.9999999999717443 16.165343379076603 -0.00000000045676359547442036 ATG3;GABARAPL1;ULK2;PIK3C3;ATG12;GABARAP
benzoate degradation via coa ligation 5/21 0.7066036560613663 0.9999999999717443 16.69967206292102 -0.0000000004718614430780654 SH3GLB1;DHRS7;ECHS1;ACYP2;ACAT1
linoleic acid metabolism 3/31 0.9882606886343842 0.9999999999717443 18.32630164159351 -0.0000000005178230510338333 PLA2G12A;PLA2G2D;RDH11
dna polymerase 5/24 0.7964624866134399 0.9999999999717443 18.591814010060393 -0.0000000005253252971179366 POLB;POLE4;RFC5;PRIM2;POLD2
o glycan biosynthesis 5/27 0.8631534028181777 0.9999999999717443 18.86721243837233 -0.0000000005331068810505478 GALNT11;WBSCR17;OGT;GALNT9;B4GALT5
pentose and glucuronate interconversions 5/25 0.821109698092644 0.9999999999717443 19.203268774190494 -0.0000000005426023985060534 UGP2;DCXR;RPE;AKR1B1;GUSB
gamma hexachlorocyclohexane degradation 5/23 0.7692221230759999 0.9999999999717443 19.23844129857929 -0.0000000005435962238968912 DHRS7;ALPP;PON2;CMBL;ACP1
glycan structures degradation 4/29 0.9521374691599758 0.9999999999717443 19.458273251820533 -0.0000000005498077364523622 MAN2B2;IDS;GUSB;GNS
glycosylphosphatidylinositol anchor biosynthesis 5/23 0.7692221230759999 0.9999999999717443 20.638138102706627 -0.0000000005831456803999165 PGAP1;GPAA1;PIGG;PIGW;PIGX
aminophosphonate metabolism 4/16 0.6704436000169323 0.9999999999717443 20.84459499865221 -0.0000000005889792709331464 PRMT2;WBSCR22;CHPT1;LCMT1
1 and 2 methylnaphthalene degradation 4/20 0.8065002959793232 0.9999999999717443 20.873148197168835 -0.0000000005897860624321522 SH3GLB1;ADH4;DHRS7;ADH5
naphthalene and anthracene degradation 4/18 0.7453430957389678 0.9999999999717443 21.031555212702802 -0.0000000005942619684656311 DHRS7;PRMT2;WBSCR22;LCMT1
pantothenate and coa biosynthesis 4/16 0.6704436000169323 0.9999999999717443 21.39913280546866 -0.0000000006046481420810261 PANK3;PPCS;BCAT1;PPCDC
methionine metabolism 4/17 0.7096541430377566 0.9999999999717443 21.73623343039287 -0.0000000006141731666886909 MTFMT;MARS;AMD1;MAT2B
ubiquinone biosynthesis 4/15 0.6277254542508556 0.9999999999717443 22.470422415795056 -0.0000000006349182132284431 NDUFA13;NDUFA12;NDUFB11;ND2
heparan sulfate biosynthesis 3/19 0.891816909183133 0.9999999999717443 25.21141991301201 -0.0000000007123671014243905 EXTL2;HS6ST1;HS6ST3
glycosphingolipid biosynthesis neo lactoseries 2/21 0.975376256049903 0.9999999999717443 26.62429732433014 -0.0000000007522889856197837 FUT9;B3GNT1
glycosaminoglycan degradation 3/17 0.8486733410092364 0.9999999999717443 26.829135196172825 -0.0000000007580768294433362 IDS;GUSB;GNS
nicotinate and nicotinamide metabolism 2/20 0.9696002643276386 0.9999999999717443 26.87712632729109 -0.0000000007594328539388527 NNT;NMNAT2
streptomycin biosynthesis 3/10 0.5691691402669102 0.9999999999717443 27.63748002505349 -0.0000000007809172035550662 IMPA1;PGM1;HK1
caprolactam degradation 3/14 0.7563314791094592 0.9999999999717443 27.849501224004484 -0.0000000007869080175377126 ECHS1;HSD17B4;SIRT2
keratan sulfate biosynthesis 3/16 0.82193887986762 0.9999999999717443 27.893238426952028 -0.000000000788143844182767 CHST1;B3GNT1;CHST2
bisphenol a degradation 3/14 0.7563314791094592 0.9999999999717443 27.916873753752395 -0.0000000007888116776210298 DHRS7;RDH11;PON2
sulfur metabolism 3/14 0.7563314791094592 0.9999999999717443 28.318460768135303 -0.0000000008001588123081157 SULT1A1;SUOX;PAPSS1
chondroitin sulfate biosynthesis 3/17 0.8486733410092364 0.9999999999717443 28.725832671744236 -0.0000000008116694032695496 CHSY1;B3GAT1;B3GALT6
renin angiotensin system 2/17 0.9433704070539156 0.9999999999717443 29.45423861617668 -0.0000000008322510457587864 NLN;AGT
alpha linolenic acid metabolism 2/15 0.9151087477981884 0.9999999999717443 30.084534103040937 -0.0000000008500605055419947 PLA2G12A;PLA2G2D
glycosphingolipid biosynthesis ganglioseries 2/16 0.9305881410277623 0.9999999999717443 30.34156166316926 -0.0000000008573230071633451 ST3GAL5;B4GALNT1
ethylbenzene degradation 2/10 0.7772914569248697 0.9999999999717443 34.57945989467559 -0.0000000009770679199737336 SH3GLB1;DHRS7
n glycan degradation 1/15 0.9812477410504318 0.9999999999717443 36.21756373184614 -0.0000000010233537414920641 MAN2B2
circadian rhythm 2/11 0.8151318781317332 0.9999999999717443 39.93761617665054 -0.0000000011284665430080272 CSNK1D;CSNK1E
c21 steroid hormone metabolism 1/11 0.9492547555561768 0.9999999999717443 40.242800876741484 -0.0000000011370897598261585 AKR1D1
glycosphingolipid biosynthesis globoseries 1/14 0.975946574048225 0.9999999999717443 41.252440157995984 -0.000000001165617855853795 FUT9
phenylpropanoid biosynthesis 1/7 0.8628066172942529 0.9999999999717443 47.26379823479233 -0.000000001335473173149167 PRDX6
tetrachloroethene degradation 1/7 0.8628066172942529 0.9999999999717443 50.64170332084885 -0.0000000014309183509036675 RDH11
atrazine degradation 1/9 0.9165522364484563 0.9999999999717443 53.12502385151389 -0.0000000015010863880249924 ADAR
nucleotide sugars metabolism 1/6 0.8241045557631035 0.9999999999717443 71.19905323296864 -0.000000002011781301915226 UGP2
cell adhesion molecules 38/133 0.49876901986733424 0.9818140766931915 3.2309216325928856 -0.05929813804525428 ITGB1;CNTNAP2;CNTNAP1;NLGN2;NRXN1;ITGB2;SDC3;NRXN3;NRXN2;F11R;PVR;GLG1;PTPRF;SPN;ALCAM;CDH2;ITGAV;NCAM1;NRCAM;NEO1;CD99;HLA-DPA1;JAM3;CADM1;NEGR1;HLA-B;HLA-C;HLA-A;L1CAM;HLA-G;HLA-E;CLDN11;CLDN10;MAG;NFASC;CLDN14;CNTN1;CNTN2
pyrimidine metabolism 25/84 0.4405795798261384 0.9815443803721564 3.2715114132122345 -0.060941876228953216 PRIM2;AK3;POLR2B;POLR2C;POLD2;POLR2E;POLR2F;POLR2G;POLR2H;POLR2I;POLR2J;POLR2L;RFC5;DUT;RRM1;PNPT1;ENTPD3;ENTPD4;POLR3GL;TXNRD1;ENTPD6;NME4;NME1;DCTD;POLE4
focal adhesion 54/192 0.5293145167983309 0.9818140766931915 3.767134464307581 -0.0691394236387824 ITGB1;GSK3B;PTEN;PIK3CB;ARHGAP5;ELK1;ACTB;ACTG1;CRKL;MYLK;PPP1CB;PPP1CC;CCND3;CCND2;CCND1;AKT3;CAPN2;TNR;ITGAV;RAC1;HRAS;MAP2K1;PDPK1;ACTN1;PRKCA;PGF;RHOA;TLN2;BIRC2;BIRC3;SHC3;ROCK2;PDGFA;PIK3R2;PIK3R1;CDC42;RAP1B;MAPK9;MAPK8;PAK1;PAK7;SPP1;MAPK1;PAK6;FYN;PIP5K1C;PAK3;PAK2;MAPK3;JUN;PTK2;MAPK10;CTNNB1;GRB2
thyroid cancer 16/29 0.02548497158795172 0.2571714877401377 0.060453620374347844 -0.0820967509278328 TCF7L2;MAP2K1;MAP2K2;TPM3;NCOA4;RXRB;RXRA;CCND1;TFG;TPR;CCDC6;CTNNB1;MAPK1;KRAS;HRAS;MAPK3
adherens junction 30/75 0.06579481053991348 0.3859962218341591 0.0870636517089227 -0.08287830151240706 WASL;ACVR1B;NLK;MLLT4;ACTB;PTPRF;ACTG1;CDC42;CTNNA1;MAPK1;FYN;CTNNA2;RAC1;WASF1;ACP1;WASF2;WASF3;MAPK3;SMAD2;TCF7L2;CREBBP;CSNK2A1;ACTN1;SORBS1;BAIAP2;RHOA;TJP1;CSNK2B;CTNNB1;SSX2IP
glycerophospholipid metabolism 18/62 0.49845725298987925 0.9818140766931915 4.64171431360185 -0.08519086732342221 CDS1;SH3GLB1;PLA2G12A;PLA2G2D;CHKB;AGPAT1;DGKZ;AGPAT3;AGPAT4;GNPAT;PTDSS1;DGKQ;PPAP2B;PPAP2A;CHPT1;GPD1L;CDIPT;CDS2
adipocytokine signaling pathway 20/71 0.5411134399956794 0.9818140766931915 4.828131327566481 -0.08861223840111918 ADIPOQ;STAT3;ACSL6;SLC2A1;IRS2;PTPN11;ACSL3;TYK2;CPT1C;ACACB;CAMKK2;MAPK10;NFKBIA;RXRB;MAPK9;MAPK8;RXRA;LEP;AKT3;JAK1
glycerolipid metabolism 16/55 0.5009118356591006 0.9818140766931915 5.14430284683489 -0.09441503541310053 AGK;AKR1B1;AGPAT1;DGKZ;LIPA;ADH5;AGPAT3;AGPAT4;ADH4;ALDH2;DGKQ;PPAP2B;PPAP2A;ALDH7A1;MGLL;ALDH9A1
ppar signaling pathway 19/67 0.5319170878894247 0.9818140766931915 5.1544526841187075 -0.09460131862291941 PDPK1;ADIPOQ;ACSL6;DBI;ACSL3;SORBS1;CPT1C;RXRB;RXRA;FABP5;SCP2;SCD;FABP7;UBC;ME1;ACADM;ANGPTL4;ACAA1;PPARD
mapk signaling pathway 81/248 0.12924981834033047 0.5809193000540741 0.23259297750052899 -0.1263313476250367 ATF2;PTPRR;ARRB1;FGF1;ELK1;CRKL;ELK4;PPP3CA;PPP3CB;FGF9;RPS6KA2;AKT3;STMN1;RAC1;HRAS;PRKACB;MAP3K4;MAP3K5;MAP2K4;MAP2K1;MEF2C;PLA2G12A;DUSP3;MAP2K2;DUSP1;CACNA2D1;PRKCA;DUSP8;MAPK8IP2;MAPK8IP3;CDC25B;CACNB2;PPM1A;CACNB3;PPM1B;MRAS;RASA1;RASA2;RAPGEF2;MAPT;ATF4;MAX;SRF;CACNA1B;CACNA1A;PDGFA;CACNA1C;ACVR1B;NLK;STK4;CACNA1E;RASGRP1;CDC42;RAP1B;MAPK9;MAPK8;PAK1;MKNK1;GNA12;MKNK2;MAPK1;PAK2;CACNG4;MAP4K4;MAPK3;MAP3K2;NTRK2;JUN;PLA2G2D;JUND;MAPK10;MAPK11;FGF14;TAOK1;GRB2;KRAS;FGF13;MAP3K13;FGFR3;PTPN5;FGFR2
histidine metabolism 12/40 0.4775401944739591 0.9818140766931915 7.052743710833357 -0.12944126095289069 PRPS1;ALDH2;MAOB;PRMT2;MAOA;WBSCR22;HARS;ALDH7A1;HARS2;LCMT1;CNDP1;ALDH9A1
leukocyte transendothelial migration 33/110 0.4056827302047678 0.9465295074484319 2.5068421021625116 -0.1377588286789724 ITGB1;ROCK2;ITGB2;PIK3R2;PIK3CB;PIK3R1;THY1;ARHGAP5;F11R;MLLT4;GNAI1;GNAI2;CDC42;RAP1B;RASSF5;CTNNA1;CTNNA2;PLCG1;RAC1;CD99;JAM3;ACTN1;PRKCA;PTPN11;PTK2;RHOA;CLDN11;CLDN10;MAPK11;CLDN14;CTNNB1;EZR;RAPGEF4
glutathione metabolism 11/37 0.49346578106188377 0.9818140766931915 8.047468423768377 -0.14769776174499122 GSTM3;GSTM2;GPX1;GPX4;GSTA4;GSS;GSTP1;MGST3;GSR;IDH2;MGST1
bile acid biosynthesis 11/38 0.5239391197930161 0.9818140766931915 8.204294100702308 -0.15057603355018065 HADHB;ADH4;ALDH2;RDH11;SRD5A1;AKR1D1;ACAA1;ALDH7A1;LIPA;ADH5;ALDH9A1
chronic myeloid leukemia 23/75 0.3976972621816192 0.9458745695130404 2.871793402798752 -0.15980183153533853 MAP2K1;CDKN1B;MAP2K2;SHC3;CTBP2;CTBP1;PIK3R2;PTPN11;PIK3CB;PIK3R1;ACVR1B;CRKL;BCR;NFKBIA;CCND1;AKT3;MDM2;MAPK1;GRB2;KRAS;HRAS;BCL2L1;MAPK3
calcium signaling pathway 51/169 0.35469500919410935 0.90472929881396 2.146349249913433 -0.2148914080589807 CHRM2;CHRM3;RYR2;CHRM1;ATP2A2;HTR2A;SLC8A1;MYLK;PPP3CA;GRM5;PPP3CB;PRKACB;SPHK2;F2R;PRKCA;ITPKB;ADCY9;VDAC3;VDAC2;VDAC1;PLCB1;SLC25A5;SLC25A4;PPID;SLC25A6;CAMK2B;CAMK2D;PDE1A;CAMK2A;CACNA1B;ADCY3;CACNA1A;ADCY2;ADCY1;CACNA1C;CACNA1E;GRIN2A;ERBB4;GNA11;PLCG1;CAMK2G;ATP2B4;ATP2B3;ATP2B2;ATP2B1;GRIN2C;GNAQ;GNAS;CALM3;CALM1;CALM2
phenylalanine metabolism 7/24 0.5376413041674282 0.9818140766931915 12.141297219615433 -0.2228331109348007 SH3GLB1;GOT1;MAOB;MAOA;GOT2;MIF;PRDX6
nitrogen metabolism 7/24 0.5376413041674282 0.9818140766931915 12.813495777566416 -0.23517018605327383 GLUD1;GLUD2;CA2;ASNS;GLUL;ASRGL1;GLS
purine metabolism 47/139 0.15455204968658304 0.6230344267071429 0.49776009584220043 -0.23551693258294076 GUCY1B3;PRIM2;PRPS1;GDA;PDE1A;AK1;ADCY3;ADCY2;ADCY1;AK5;PAPSS1;ATIC;GUK1;POLR2B;POLR2C;POLD2;PDE4B;POLR2E;PDE4A;POLR2F;POLR2G;POLR2H;PDE8B;POLR2I;ADSS;POLR2J;POLR2L;GUCY1A3;RFC5;GUCY1A2;ADSL;RRM1;PNPT1;ENTPD3;ENTPD4;POLR3GL;ENTPD6;PDE2A;PDE4C;AMPD2;NME4;PAICS;NME1;POLE4;ADCY9;HPRT1;GART
melanogenesis 32/100 0.29265200020422283 0.8537006574215422 1.511671882869616 -0.23910819348323253 CAMK2B;GSK3B;CAMK2D;CAMK2A;ADCY3;ADCY2;ADCY1;GNAI1;GNAI2;MAPK1;CAMK2G;HRAS;PRKACB;MAPK3;TCF7L2;CREBBP;FZD3;MAP2K1;MAP2K2;PRKCA;GNAO1;KITLG;ADCY9;CREB1;GNAQ;GNAS;CTNNB1;CALM3;KRAS;CALM1;PLCB1;CALM2
fc epsilon ri signaling pathway 23/74 0.3766312496915532 0.9092553308202304 2.8392573416257316 -0.2700966550117311 MAP2K4;MAP2K1;PLA2G12A;PLA2G2D;MAP2K2;PRKCE;PIK3R2;PRKCA;PIK3CB;PIK3R1;MAPK10;MAPK11;MAPK9;MAPK8;AKT3;MAPK1;FYN;GRB2;KRAS;PLCG1;RAC1;HRAS;MAPK3
3 chloroacrylic acid degradation 5/15 0.4568528711671643 0.9818140766931915 14.933800423575207 -0.27408481534315915 ADH4;ALDH2;ALDH7A1;ADH5;ALDH9A1
glioma 25/62 0.08260125118791302 0.4543068815335216 0.3634760398283295 -0.28677618326306936 CAMK2B;CAMK2D;SHC3;CAMK2A;PTEN;PDGFA;PIK3R2;PIK3CB;PIK3R1;CCND1;AKT3;MAPK1;PLCG1;CAMK2G;HRAS;MAPK3;MAP2K1;MAP2K2;PRKCA;MDM2;CALM3;GRB2;KRAS;CALM1;CALM2
colorectal cancer 27/84 0.30670434385869383 0.8537006574215422 1.8829329106914043 -0.2978322821423934 GSK3B;PIK3R2;PIK3CB;PIK3R1;ACVR1B;MAPK9;MAPK8;CCND1;AKT3;MAPK1;RAC1;RALGDS;APPL1;MAPK3;SMAD2;TCF7L2;FZD3;JUN;MAP2K1;MAPK10;APC;MSH3;BAX;CTNNB1;CYCS;GRB2;KRAS
dorso ventral axis formation 9/28 0.42712690739562986 0.963773534636293 8.122624793078591 -0.29971620058706244 CPEB1;MAP2K1;ERBB4;MAPK1;SPIRE1;GRB2;KRAS;FMN2;MAPK3
alzheimers disease 9/28 0.42712690739562986 0.963773534636293 8.836446577690532 -0.32605546389545415 BACE1;APP;GSK3B;APOE;MAPT;NAE1;A2M;GAPDH;SNCA
cyanoamino acid metabolism 2/6 0.5531901248552847 0.9934843058625522 50.307041755377774 -0.3288578328222091 SHMT2;ASRGL1
riboflavin metabolism 5/16 0.5037987921897109 0.9818140766931915 17.96188899429068 -0.3296602933331474 MTMR1;RFK;PHPT1;ACP1;LHPP
prostate cancer 29/86 0.2278002061332695 0.756468609046329 1.2577203882412622 -0.3510225178965083 GSK3B;CDKN1B;GSTP1;PTEN;PDGFA;PIK3R2;PIK3CB;PIK3R1;HSP90B1;CCND1;AKT3;MAPK1;HRAS;MAPK3;TCF7L2;CREBBP;MAP2K1;MAP2K2;PDPK1;SRD5A1;NFKBIA;CREB1;MDM2;CTNNB1;GRB2;KRAS;FGFR2;ATF4;CREB5
glycolysis and gluconeogenesis 25/63 0.09234176114950249 0.47800441065624816 0.5408457039757738 -0.3992173163523425 GPI;ENO1;PDHB;ENO2;ADH5;HK1;ADH4;LDHB;LDHA;ALDH2;PGK1;PGM1;PDHA1;TPI1;PGAM1;ACYP2;ALDOC;ALDOA;ALDH7A1;DLD;GAPDH;PFKM;LDHAL6A;PFKP;ALDH9A1
pancreatic cancer 27/73 0.13532779148986954 0.5809193000540741 0.7591145501098311 -0.4123080806123233 RALA;RALB;PIK3R2;PIK3CB;PIK3R1;ACVR1B;CDC42;MAPK9;MAPK8;CCND1;AKT3;MAPK1;RAC1;RALGDS;JAK1;MAPK3;SMAD2;MAP2K1;RALBP1;STAT1;STAT3;PGF;MAPK10;RAD51;KRAS;ARHGEF6;BCL2L1
ascorbate and aldarate metabolism 3/9 0.5105214795372185 0.9818140766931915 22.89640304095863 -0.42022500780155086 ALDH2;ALDH7A1;ALDH9A1
vegf signaling pathway 22/68 0.3221216033382684 0.858211112113798 2.8793739307281565 -0.4402711268129625 NFAT5;MAP2K1;PLA2G12A;PLA2G2D;MAP2K2;SPHK2;PIK3R2;PRKCA;PIK3CB;PIK3R1;PTK2;CDC42;MAPK11;PPP3CA;PPP3CB;AKT3;MAPK1;KRAS;PLCG1;RAC1;HRAS;MAPK3
endometrial cancer 22/52 0.07247600076755181 0.41147664951900387 0.5179556598989256 -0.45994618258418085 GSK3B;TCF7L2;MAP2K1;MAP2K2;PDPK1;PTEN;PIK3R2;PIK3CB;PIK3R1;FOXO3;ELK1;APC;CCND1;AKT3;CTNNA1;CTNNB1;MAPK1;GRB2;KRAS;CTNNA2;HRAS;MAPK3
thiamine metabolism 3/8 0.4478928116740251 0.9818140766931915 26.821783255758824 -0.492268766309717 MTMR1;PHPT1;LHPP
synthesis and degradation of ketone bodies 3/9 0.5105214795372185 0.9818140766931915 29.307613558985395 -0.5378920048899452 HMGCS1;OXCT1;ACAT1
pyruvate metabolism 19/41 0.05183114471026066 0.34078199888160826 0.5041819555215044 -0.5427580793829355 PDHA1;MDH1;MDH2;GLO1;AKR1B1;ACYP2;PDHB;ACACB;ACACA;ACAT1;LDHB;LDHA;ALDH2;ME1;ME2;ALDH7A1;DLD;LDHAL6A;ALDH9A1
fructose and mannose metabolism 13/40 0.3771343133515728 0.9092553308202304 5.824565836445063 -0.5540870587019844 MTMR1;PFKFB3;TPI1;SORD;AKR1B1;HK1;RDH11;ALDOC;ALDOA;PHPT1;PFKM;PFKP;LHPP
fatty acid metabolism 15/45 0.3312029938411782 0.858211112113798 4.068029823288084 -0.6220227442827655 ACADVL;ECHS1;ACSL6;HSD17B4;ACSL3;CPT1C;ADH5;ACAT1;HADHB;ADH4;ALDH2;ACADM;ACAA1;ALDH7A1;ALDH9A1
butanoate metabolism 19/45 0.09165957163469017 0.47800441065624816 0.8775727809379084 -0.6477674647954434 ECHS1;PDHA1;HMGCS1;GAD1;GAD2;HSD17B4;ABAT;DDHD1;PDHB;PRDX6;AACS;ACAT1;ALDH5A1;ALDH2;OXCT1;PPME1;RDH11;ALDH7A1;ALDH9A1
alkaloid biosynthesis i 2/5 0.47685709202200977 0.9818140766931915 38.965966085753905 -0.7151548377746992 GOT1;GOT2
vitamin b6 metabolism 2/5 0.47685709202200977 0.9818140766931915 39.469894123647286 -0.7244035902218129 PDXK;PSAT1
non small cell lung cancer 20/53 0.16172307512783188 0.6230344267071429 1.6207952186520567 -0.7668849339884475 MAP2K1;MAP2K2;PDPK1;PIK3R2;PRKCA;PIK3CB;PIK3R1;FOXO3;STK4;RXRB;RXRA;CCND1;RASSF5;AKT3;MAPK1;GRB2;KRAS;PLCG1;HRAS;MAPK3
arginine and proline metabolism 12/34 0.3006068804357477 0.8537006574215422 4.9418933281194315 -0.781682321053924 ALDH4A1;GLUD1;GATM;GLUD2;OAT;GOT1;P4HA1;RARS;GOT2;ASL;CKB;EPRS
ether lipid metabolism 11/30 0.27816974509356107 0.8537006574215422 5.036360541509508 -0.79662464087416 PLA2G12A;PLA2G2D;PPAP2B;PPAP2A;ENPP2;CHPT1;AGPAT1;AGPAT3;PAFAH1B2;AGPAT4;PAFAH1B1
glutamate metabolism 16/30 0.03135673512326205 0.2571714877401377 0.5935241270538227 -0.8060129753465195 GOT1;GAD1;GPT2;GSS;GOT2;GSR;GAD2;ABAT;EPRS;GLS;ALDH4A1;GLUD1;GLUD2;ALDH5A1;QARS;GLUL
alkaloid biosynthesis ii 5/14 0.408728650943641 0.9465295074484319 14.766349689818972 -0.8114571856674913 SH3GLB1;PPME1;DDHD1;LIPA;PRDX6
olfactory transduction 11/31 0.307767451538983 0.8537006574215422 5.705435237514244 -0.9024553066951992 CAMK2B;CAMK2D;ADRBK2;CAMK2A;ADCY3;CALM3;CALM1;CALM2;CAMK2G;PRKACB;CNGB1
alanine and aspartate metabolism 17/33 0.03360763760240436 0.2571714877401377 0.6896716061402245 -0.936582420054991 DARS;ADSL;PDHA1;GOT1;GAD1;GPT2;GOT2;ASNS;GAD2;ABAT;PDHB;ASRGL1;NARS;ASL;ADSS;DLD;AARS
type ii diabetes mellitus 17/42 0.1326722437529175 0.5809193000540741 1.8883778095638057 -1.0256600008780057 ABCC8;PRKCE;ADIPOQ;CACNA1B;CACNA1A;IRS2;PIK3R2;CACNA1C;PIK3CB;PIK3R1;CACNA1E;PRKCZ;MAPK10;MAPK9;MAPK8;MAPK1;MAPK3
beta alanine metabolism 9/24 0.28957959883995027 0.8537006574215422 6.573401044885978 -1.0397455074045625 ECHS1;ALDH2;GAD1;GAD2;ABAT;ACADM;ALDH7A1;CNDP1;ALDH9A1
snare interactions in vesicular transport 13/35 0.24154539500737182 0.7872590652092119 4.507801880675281 -1.0782567616623677 SNAP25;STX12;STX16;GOSR1;STX7;VAMP7;STX6;VAMP1;SEC22B;VAMP4;VAMP2;VAMP3;VTI1B
urea cycle and metabolism of amino groups 10/28 0.3152871746159105 0.8537006574215422 6.889664249289831 -1.0897703337753961 GATM;ALDH2;MAOB;MAOA;AMD1;ASL;SAT2;ALDH7A1;SAT1;ALDH9A1
inositol phosphate metabolism 19/46 0.10405330109783892 0.48193107876893815 1.4998754390396762 -1.0948403241004836 INPP1;ITPK1;PTEN;PIK3CB;SYNJ2;INPP4A;ITPKB;INPP5A;IMPA1;SYNJ1;PI4KA;PIP4K2A;PIK3C3;PIP4K2B;PI4KB;PIP4K2C;PIP5K1C;PLCG1;PLCB1
valine leucine and isoleucine degradation 17/44 0.16679922238974929 0.6230344267071429 2.3982004004312776 -1.1347169183441586 ECHS1;HMGCS1;HSD17B4;ABAT;MUT;ACAT1;HADHB;ALDH6A1;ALDH2;OXCT1;DBT;ACADM;ACAA1;BCAT1;ALDH7A1;DLD;ALDH9A1
propanoate metabolism 16/33 0.05486459358881923 0.34486315970114945 1.2256710967718603 -1.3048587392052409 ECHS1;ABAT;ACACB;MUT;ACACA;ACAT1;LDHB;ALDH6A1;LDHA;SUCLA2;ALDH2;SUCLG1;ACADM;ALDH7A1;LDHAL6A;ALDH9A1
biosynthesis of steroids 8/22 0.3315815660439674 0.858211112113798 9.32648962525381 -1.426068372954081 FDPS;IDI1;SQLE;CYP51A1;PMVK;HSD17B7;LSS;FDFT1
polyunsaturated fatty acid biosynthesis 5/13 0.36004848738987494 0.9052647682945427 16.152755763300824 -1.6076485102642435 ELOVL5;SCD;FASN;HSD17B12;ACAA1
huntingtons disease 14/31 0.09872882261831983 0.48193107876893815 2.4835879164627532 -1.8129053444152015 CREBBP;DCTN1;CLTC;CLTB;CLTA;NCOR1;RASA1;BAX;CALM3;GRB2;CALM1;CALM2;GAPDH;UBE2K
dentatorubropallidoluysian atrophy 6/15 0.3066259238996773 0.8537006574215422 11.778294385097054 -1.8630277672348337 MAGI1;RERE;MAGI2;WWP1;BAIAP2;GAPDH
methane metabolism 4/10 0.370859467328862 0.9092553308202304 19.640605919917505 -1.8683977262645055 SHMT2;CAT;PRDX6;ADH5
citrate cycle 14/28 0.0596558709863958 0.36204942391743655 2.04101574405849 -2.0736200445958732 FH;MDH1;MDH2;IDH2;SDHC;SDHB;CS;ACLY;SUCLA2;IDH3B;SUCLG1;ACO2;DLD;IDH3A
carbon fixation 12/22 0.05227905664661036 0.34078199888160826 2.489846559346864 -2.6803504602053825 TPI1;GOT1;MDH1;MDH2;GPT2;RPE;GOT2;ME1;PGK1;ALDOC;ALDOA;TKT
one carbon pool by folate 7/16 0.22599356375652183 0.756468609046329 9.607447777253922 -2.681383351069576 DHFR;MTFMT;ATIC;MTHFD1;MTHFD2;SHMT2;GART
rna polymerase 10/23 0.16991848001103899 0.6230344267071429 5.950840688384653 -2.815661112501913 POLR2B;POLR3GL;POLR2C;POLR2E;POLR2F;POLR2G;POLR2H;POLR2I;POLR2J;POLR2L
phenylalanine tyrosine and tryptophan biosynthesis 4/9 0.3150292770830582 0.8537006574215422 18.792412615403798 -2.972483567750711 YARS;GOT1;GOT2;FARSB
prion disease 6/13 0.22374402944868962 0.756468609046329 11.62286195605757 -3.243873842805385 PRNP;HSPA5;APLP1;GFAP;HSPD1;NFE2L2
cysteine metabolism 8/17 0.16428380818736638 0.6230344267071429 7.390002090016023 -3.4966053698564417 CARS;LDHB;LDHA;GOT1;GOT2;CDO1;SULT4A1;LDHAL6A
fatty acid elongation in mitochondria 5/10 0.2183496910521878 0.756468609046329 12.66872953919591 -3.535769462731626 HADHB;ECHS1;MECR;PPT1;HSD17B4
parkinsons disease 9/17 0.09673655614297783 0.48193107876893815 5.083693877884401 -3.710863521076279 PINK1;UCHL1;UBB;UBA1;PARK7;UBE2G2;STX1A;SNCA;UBE2L3
taurine and hypotaurine metabolism 3/6 0.314928070875697 0.8537006574215422 25.37760957748496 -4.014094890404588 GAD1;GAD2;CDO1
glyoxylate and dicarboxylate metabolism 7/14 0.15868115614835748 0.6230344267071429 9.034598567645602 -4.274751952885907 CS;MDH1;MTHFD1;MDH2;MTHFD2;AFMID;ACO2
fatty acid biosynthesis 3/6 0.314928070875697 0.8537006574215422 29.346280815734495 -4.641838133538362 FASN;ACACB;ACACA
valine leucine and isoleucine biosynthesis 6/12 0.18541177496982708 0.6659688243814197 11.950875280974744 -4.85817922890413 PDHA1;LARS;IARS;PDHB;BCAT1;VARS2
reductive carboxylate cycle 7/12 0.1023585569340885 0.48193107876893815 8.809544714355102 -6.4305638583012374 ACLY;FH;SUCLA2;MDH1;MDH2;IDH2;ACO2
protein export 7/8 0.02940862953394762 0.2571714877401377 5.5569181134031655 -7.5463623097749615 SEC61A2;OXA1L;SRP19;SRP72;SRPR;SRP68;SRP9
terpenoid biosynthesis 4/6 0.15788391927061396 0.6230344267071429 18.255208153842688 -8.637515670639687 FDPS;IDI1;SQLE;FDFT1