diff --git a/.github/ISSUE_TEMPLATE.md b/.github/ISSUE_TEMPLATE.md
index fc426618de5..27903e875cf 100644
--- a/.github/ISSUE_TEMPLATE.md
+++ b/.github/ISSUE_TEMPLATE.md
@@ -25,4 +25,4 @@ If this is a **feature request**, show what you expect to happen if the feature
 
 
 #### Current Version:
-v4.5.0
+v4.6.0
diff --git a/RELEASE-NOTES.txt b/RELEASE-NOTES.txt
index 1293acb9a89..b486ef4a48a 100644
--- a/RELEASE-NOTES.txt
+++ b/RELEASE-NOTES.txt
@@ -1,5 +1,21 @@
 Stan Math Library Release Notes
 
+======================================================================
+v4.6.0 (20 April 2023)
+======================================================================
+
+- Updated to Eigen 3.4 (#2583)
+- operands_and_partials expanded to accept 8 parameters. (#2833)
+- Added new multidimensional integration routine `hcubature`. (#2838)
+- Added eigenvalues and eigenvectors overloads which accept matrices with complex values. (#2846)
+- Allowed Sundials to be linked to separately installed version. (#2861)
+- Fixed `is_nan` to compile under the Microsoft compiler suite. (#2870)
+- Fixed `csr_to_dense_matrix` to work in case of matrix with empty first row. (#2877)
+- Fixed a bug where `eigenvalues_sym` would return a matrix with a dynamic number of rows equal to 1, rather than a vector. (#2884)
+- Updated `eigenvalues_sym` return type for RcppEigen compatibility. (#2887)
+- Various testing improvements. (#2832, #2864, #2869, #2878, #2880)
+- Fixed an issue with building TBB on gcc 13. (#2890)
+
 ======================================================================
 v4.5.0 (21 November 2022)
 ======================================================================
diff --git a/doxygen/doxygen.cfg b/doxygen/doxygen.cfg
index 41ea76ecfed..068bb646eea 100644
--- a/doxygen/doxygen.cfg
+++ b/doxygen/doxygen.cfg
@@ -38,7 +38,7 @@ PROJECT_NAME           = "Stan Math Library"
 # could be handy for archiving the generated documentation or if some version
 # control system is used.
 
-PROJECT_NUMBER         = 4.5.0
+PROJECT_NUMBER         = 4.6.0
 
 # Using the PROJECT_BRIEF tag one can provide an optional one line description
 # for a project that appears at the top of each page and should give viewer a
diff --git a/stan/math/version.hpp b/stan/math/version.hpp
index 6108cc3aff4..47663c056c7 100644
--- a/stan/math/version.hpp
+++ b/stan/math/version.hpp
@@ -12,7 +12,7 @@
 #endif
 
 #define STAN_MATH_MAJOR 4
-#define STAN_MATH_MINOR 5
+#define STAN_MATH_MINOR 6
 #define STAN_MATH_PATCH 0
 
 namespace stan {