From 99b711a5c33d0e273112a5d840d290bd86d91e80 Mon Sep 17 00:00:00 2001 From: dtaliun Date: Fri, 14 Dec 2018 09:37:13 -0500 Subject: [PATCH] Update README.md --- README.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/README.md b/README.md index d8c6742..0b13930 100644 --- a/README.md +++ b/README.md @@ -31,7 +31,7 @@ The compiled `metal` executable will be installed into `build/bin` directory. - 2017-12-21 - Correction for sample overlap in sample size weighted meta-analysis (developed by Sebanti Sengupta). First, METAL estimates the number of individuals that are common among two or more studies based on Z-statistics from each study. Then, METAL adjusts for sample overlap when calculating overall Z-statistics by correcting the weights with the estimated number of individuals in common. - To enable correction for sample overlap in your sample size weighted meta-analysis, use `OVERLAP ON` command (valid only with `SCHEME SAMPLESIZE`). By default, METAL uses Z-statistics <1 for esimating the number of individuals that are common among studies. To change this threshold, use `ZCUTOFF [number]` command. The `N` column in the result file will store sample size corrected for overlap between studies. + To enable correction for sample overlap in your sample size weighted meta-analysis, use `OVERLAP ON` command (valid only with `SCHEME SAMPLESIZE`) before any `PROCESS` commands. By default, METAL uses Z-statistics <1 for esimating the number of individuals that are common among studies. To change this threshold, use `ZCUTOFF [number]` command. The `N` column in the result file will store sample size corrected for overlap between studies. More information on this specific method can be found on our wiki: https://genome.sph.umich.edu/wiki/METAL_Documentation#Sample_Overlap_Correction