diff --git a/Transport/Connection.php b/Transport/Connection.php
index b49bc95..260e226 100644
--- a/Transport/Connection.php
+++ b/Transport/Connection.php
@@ -13,6 +13,7 @@
 
 use Symfony\Component\Messenger\Exception\InvalidArgumentException;
 use Symfony\Component\Messenger\Exception\LogicException;
+use Symfony\Component\Messenger\Exception\TransportException;
 
 /**
  * An AMQP connection.
@@ -493,7 +494,7 @@ public function channel(): \AMQPChannel
                 $this->amqpChannel->confirmSelect();
                 $this->amqpChannel->setConfirmCallback(
                     static fn (): bool => false,
-                    static fn (): bool => false
+                    static fn () => throw new TransportException('Message publication failed due to a negative acknowledgment (nack) from the broker.'),
                 );
             }