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Clinical references

cesine edited this page Oct 23, 2011 · 17 revisions

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Touch Tablets in Clinical Settings

the face of mobile and participatory healthcare: an overview, with example from eCAALYX. Biomed Eng Online. 2011 Apr 5;10(1):24. [Epub] PubMed PMID: 21466669.

ABSTRACT: The latest generation of smartphones are increasingly viewed as handheld computers rather than as phones, due to their powerful on-board computing capability, capacious memories, large screens and open operating systems that encourage application development. This paper provides a brief state-of-the-art overview of health and healthcare smartphone apps (applications) on the market today, including emerging trends and market uptake. Platforms available today include Android, Apple iOS, RIM BlackBerry, Symbian, and Windows (Windows Mobile 6.x and the emerging Windows Phone 7 platform). The paper covers apps targeting both laypersons/patients and healthcare professionals in various scenarios, e.g., health, fitness and lifestyle education and management apps; ambient assisted living apps; continuing professional education tools; and apps for public health surveillance. Among the surveyed apps are those assisting in chronic disease management, whether as standalone apps or part of a BAN (Body Area Network) and remote server configuration. We describe in detail the development of a smartphone app within eCAALYX (Enhanced Complete Ambient Assisted Living Experiment, 2009-2012), an EU-funded project for older people with multiple chronic conditions. The eCAALYX Android smartphone app receives input from a BAN (a patient-wearable smart garment with wireless health sensors) and the GPS (Global Positioning System) location sensor in the smartphone, and communicates over the Internet with a remote server accessible by healthcare professionals who are in charge of the remote monitoring and management of the older patient with multiple chronic conditions. Finally, we briefly discuss barriers to adoption of health and healthcare smartphone apps (e.g., cost, network bandwidth and battery power efficiency, usability, privacy issues, etc.), as well as some workarounds to mitigate those barriers.

  • Kubben PL. Neurosurgical apps for iPhone, iPod Touch, iPad and Android. Surg
Neurol Int. 2010 Dec 22;1:89. PubMed PMID: 21206897; PubMed Central PMCID: PMC3011112.

The second project we are collaborating on is NeuroMind. Within six months after its release, it became the #1 ranked neurosurgical app in the App Store with over 30,000 downloads. It has been mentioned in several magazines and weblogs, for example the widely cited “Top 10 Free Medical iPhone apps” on iMedicalApps. com. From user evaluations, we learned that residents and neurosurgeons value the “Scores” the most for use in daily practice, followed by some anatomical illustrations for explanation to patients and students. Therefore, this part will be improved in the next major update, that will run on iPhone, iPod Touch, iPad and Android as well. An illustration of the new layout is visible in Figure 2. A first version for Android is already available in the Android Market, and the major upgrade is expected within two-three months. A web-based version is being developed to access the content from desktop computers and other mobile devices.

  • Sadasivam RS, Gathibandhe V, Tanik MM, Willig JH. Development of a
Point-of-Care HIV/Aids Medication Dosing Support System Using the Android Mobile Platform. J Med Syst. 2010 Nov 6. [Epub] PubMed PMID: 21057886.

Division of Health Informatics and Implementation Science, Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA, [email protected].

Medication dosing errors can greatly reduce HIV treatment effectiveness as incorrect dosing leads to drug resistance and non-adherence. In order to dose correctly, HIV therapy providers must balance several patient characteristics such as renal functions and weight. In developing countries and other resource-limited settings, dosing errors are more likely because treatment is provided by mid-level providers with only basic training in HIV therapy. These providers also typically lack electronic tools informing medical decisions. Widespread adoption of mobile phones in developing nations offers an opportunity to implement a point-of-care system to help providers reduce dosing errors. We discuss the development of the mHIV-Dr system prototype using the new Android mobile platform. mHIV-Dr is being designed to provide dosing recommendations for front-line providers in developing countries. We also discuss the additional challenges in the implementation of the mHIV-Dr system in a resource limited setting.

  • Wilhite SE. Android ('an, droid). HDA Now. 2010 Fall:20. PubMed PMID:
21322178.
  • Gamble KH. Wireless Tech Trends 2010. Trend: smartphones. Healthc Inform. 2010
Feb;27(2):24, 26-7. PubMed PMID: 20218065.

THE LANDSCAPE: Physician use of handhelds is by no means a new concept. But as the devices--particularly the RIM BlackBerry, Apple iPhone and Google Android--become more sophisticated and more applications become available, the game is changing, quickly. And with so many hospitals upgrading their infrastructures to offer ubiquitous wireless coverage, clinicians are using smartphones in the hospital setting to access online tools such as drug references, and communicate with colleagues. For ClOs, it's a no-brainer--physicians and nurses are already carrying these devices, so why not capitalize on the trend by enabling users to access clinical information and link to patient records. A number of organizations have adopted this thinking and are on the road to enabling EMR access via mobile devices. And while there are certainly sticking points, it's an area that many say is poised for significant growth in the next few years. THE FUTURE: Many innovative organizations are looking to provide access to electronic records and other clinical data through smartphones. Plans are already being formulated to leverage the devices to facilitate patient handoff and sign-out, as well as to link charge capture with quality measures. Cutting-edge organizations are looking to create actionable information for clinicians through software that can analyze data, track patients'progress, and send out alerts when conditions worsen.

  • Shih G, Lakhani P, Nagy P. Is android or iPhone the platform for innovation in
imaging informatics. J Digit Imaging. 2010 Feb;23(1):2-7. PubMed PMID: 19789925; PubMed Central PMCID: PMC2809941.

It is clear that ubiquitous mobile computing platforms will be a disruptive technology in the delivery of healthcare in the near future. While radiologists are fairly sedentary, their customers, the referring physicians, and the patients are not. The need for closer collaboration and interaction with referring physicians is seen as a key to maintaining relationships and integrating tightly with the patient management team. While today, patients have to settle for their images on a CD, in short time, they will be taking them home on their cell phone. As PACS vendors are moving ever outward in the enterprise, they are already actively developing clients on mobile platforms. Two major contenders are the Apple's iPhone and the Android platform developed by Google. These two designs represent two entirely different architectures and business models.

  • Doukas C, Pliakas T, Maglogiannis I. Mobile healthcare information management
utilizing Cloud Computing and Android OS. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1037-40. PubMed PMID: 21097207.

Cloud Computing provides functionality for managing information data in a distributed, ubiquitous and pervasive manner supporting several platforms, systems and applications. This work presents the implementation of a mobile system that enables electronic healthcare data storage, update and retrieval using Cloud Computing. The mobile application is developed using Google's Android operating system and provides management of patient health records and medical images (supporting DICOM format and JPEG2000 coding). The developed system has been evaluated using the Amazon's S3 cloud service. This article summarizes the implementation details and presents initial results of the system in practice.

  • Sposaro F, Danielson J, Tyson G. iWander: An Android application for dementia
patients. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:3875-8. PubMed PMID: 21097072.

Non-pharmacological management of dementia puts a burden on those who are taking care of a patient that suffer from this chronic condition. Caregivers frequently need to assist their patients with activities of daily living. However, they are also encouraged to promote functional independence. With the use of a discrete monitoring device, functional independence is increased among dementia patients while decreasing the stress put on caregivers. This paper describes a tool which improves the quality of treatment for dementia patients using mobile applications. Our application, iWander, runs on several Android based devices with GPS and communication capabilities. This allows for caregivers to cost effectively monitor their patients remotely. The data uncollected from the device is evaluated using Bayesian network techniques which estimate the probability of wandering behavior. Upon evaluation several courses of action can be taken based on the situation's severity, dynamic settings and probability. These actions include issuing audible prompts to the patient, offering directions to navigate them home, sending notifications to the caregiver containing the location of the patient, establishing a line of communication between the patient-caregiver and performing a party call between the caregiver-patient and patient's local 911. As patients use this monitoring system more, it will better learn and identify normal behavioral patterns which increases the accuracy of the Bayesian network for all patients. Normal behavior classifications are also used to alert the caregiver or help patients navigate home if they begin to wander while driving allowing for functional independence.

  • Aanensen DM, Huntley DM, Feil EJ, al-Own F, Spratt BG. EpiCollect: linking
smartphones to web applications for epidemiology, ecology and community data collection. PLoS One. 2009 Sep 16;4(9):e6968. PubMed PMID: 19756138; PubMed Central PMCID: PMC2735776.

BACKGROUND: Epidemiologists and ecologists often collect data in the field and, on returning to their laboratory, enter their data into a database for further analysis. The recent introduction of mobile phones that utilise the open source Android operating system, and which include (among other features) both GPS and Google Maps, provide new opportunities for developing mobile phone applications, which in conjunction with web applications, allow two-way communication between field workers and their project databases. METHODOLOGY: Here we describe a generic framework, consisting of mobile phone software, EpiCollect, and a web application located within www.spatialepidemiology.net. Data collected by multiple field workers can be submitted by phone, together with GPS data, to a common web database and can be displayed and analysed, along with previously collected data, using Google Maps (or Google Earth). Similarly, data from the web database can be requested and displayed on the mobile phone, again using Google Maps. Data filtering options allow the display of data submitted by the individual field workers or, for example, those data within certain values of a measured variable or a time period. CONCLUSIONS: Data collection frameworks utilising mobile phones with data submission to and from central databases are widely applicable and can give a field worker similar display and analysis tools on their mobile phone that they would have if viewing the data in their laboratory via the web. We demonstrate their utility for epidemiological data collection and display, and briefly discuss their application in ecological and community data collection. Furthermore, such frameworks offer great potential for recruiting 'citizen scientists' to contribute data easily to central databases through their mobile phone.

  • Alac M. Moving android: on social robots and body-in-interaction. Soc Stud
Sci. 2009 Aug;39(4):491-528. PubMed PMID: 19848108.

Social robotics studies embodied technologies designed for social interaction. This paper examines the implied idea of embodiment using as data a sequence in which practitioners of social robotics are involved in designing a robot's movement. The moments of learning and work in the laboratory enact the social body as material, dynamic, and multiparty: the body-in-interaction. In describing subject-object reconfigurations, the paper explores how the well-known ideas of extending the body with instruments can be applied to a technology designed to function as our surrogate.

  • Sposaro F, Tyson G. iFall: an Android application for fall monitoring and
response. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6119-22. PubMed PMID: 19965264.

Injuries due to falls are among the leading causes of hospitalization in elderly persons, often resulting in a rapid decline in quality of life or death. Rapid response can improve the patients outcome, but this is often lacking when the injured person lives alone and the nature of the injury complicates calling for help. This paper presents an alert system for fall detection using common commercially available electronic devices to both detect the fall and alert authorities. We use an Android-based smart phone with an integrated tri-axial accelerometer. Data from the accelerometer is evaluated with several threshold based algorithms and position data to determine a fall. The threshold is adaptive based on user provided parameters such as: height, weight, and level of activity. The algorithm adapts to unique movements that a phone experiences as opposed to similar systems which require users to mount accelerometers to their chest or trunk. If a fall is suspected a notification is raised requiring the user's response. If the user does not respond, the system alerts pre-specified social contacts with an informational message via SMS. If a contact responds the system commits an audible notification, automatically connects, and enables the speakerphone. If a social contact confirms a fall, an appropriate emergency service is alerted. Our system provides a realizable, cost effective solution to fall detection using a simple graphical interface while not overwhelming the user with uncomfortable sensors.

Clinical Screening and Assessment Tools

Academy of Aphasia Annual Meeting Oct 2011

Aphasia: acquired language impairment

The Bilingual Aphasia Test is a comprehensive language test designed to assess the differential loss or sparing of various language functions in previously bilingual individuals. The individual is tested, separately, in each language he or she previously used, and then in the two languages simultaneously. The testing is multimodal -- sampling hearing, speaking, reading, and writing; and multidimensional -- testing various linguistic levels (phonological, morphological, syntactic, lexical, and semantic), tasks (comprehension, repetition, judgment, lexical access and propositionizing), and units (words, sentences, and paragraphs).

The BAT is structured as follows:

  • To test a bilingual aphasic, you will need the following testing elements: the stimulus books for each of the languages in which the individual was formerly fluent, the single-language tests for each of these languages, as well as the bilingual test that links them. For example, if you are testing an English-French bilingual aphasic, you will need an English stimulus book, a French stimulus book, an English single-language test, a French single-language test, and an English-French bilingual test.
  • Zanetti, Dario (2009) Bilingual aphasia: adaptation of the Bilingual Aphasia Test (BAT) to sardinian and study of a clinical case. Doctoral Thesis. Universita' degli studi di Sassari.
According to the Associazione Italiana Afasici, there are about 150,000 aphasics in Italy, and every year 20,000 new cases. This pathological process is devastating; in fact, they have lost that feature which makes us unique, namely language. Since, the first case of aphasia described by the French physician Paul Broca in 1861, science has made great strides. Many new theories have been proposed and have tried to explain how our brain processes language. Particularly, research on bilinguals has become interesting and important for our understanding of the neuroscientific bases of language. In this doctoral thesis, we are going to introduce and discuss, with the help of a clinical case study, one of the most plausible theories which tries to explain how our brain processes language. In addition, we are going to introduce Paradis’ Bilingual Aphasia Test, which we have adapted to Sardinian. It is very important that all languages of an aphasic patient are assessed with an equivalent instrument, not a simple translation of a standardized test from another language. The assessment of only one language is not enough, and in the worst case can even cause negative social and/or clinical results. The assessment of both languages through a standardized bilingual test allows us to compare the two languages and to ascertain which one is impaired and which recovers first and best. Based on these results, the clinician together with the patient’s family can decide which language should be treated. Deterioration of language during normal aging has been reported by several authors and has been compared with certain aphasic disorders. This paper examines the utility of the Bilingual Aphasia Test (BAT) for assessing the effect of age on the capacities of bilingual elderly people at various linguistic levels and skills with a view to determining whether the deterioration affects both languages in the same way. Our study confirms BAT as a suitable tool for assessment of bilingualism in the elderly. Results on bilingual elderly subjects speaking Galician and Spanish show that deterioration affects both languages, and support a non-modular explanation of language decline in the elderly.
  • Hambleton, R.K. 1994. Guidelines for adapting educational and psychological tests: A progress report. European Journal of Psychological Assessment, 10: 229-240.
  • Goldblum, M. C., & Paradis, M. (1989). The bilingual aphasia test, French adaptation.
Hillsdale, NJ: Lawrence Erlbaum Associates.
  • Hummel, K., & Libben, G. (1989). The bilingual aphasia test, English adaptation.
Hillsdale, NJ: Lawrence Erlbaum Associates.
  • Paradis, M., Libben, G., & Hummel, K. (1987). The bilingual aphasia test. Hillsdale, NJ:
Lawrence Erlbaum Associates.

Cognitive impairment screening in the context of dementia or stroke

OBJECTIVES: To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia. DESIGN: Validation study. SETTING: A community clinic and an academic center. PARTICIPANTS: Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC). MEASUREMENTS: The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD. RESULTS: Using a cutoff score 26, the MMSE had a sensitivity of 18% to detect MCI, whereas the MoCA detected 90% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78%, whereas the MoCA detected 100%. Specificity was excellent for both MMSE and MoCA (100% and 87%, respectively). CONCLUSION: MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE. Sarah T. Pendlebury, MRCP, DPhil; Fiona C. Cuthbertson, MCSP; Sarah J.V. Welch, RGN; Ziyah Mehta, DPhil; Peter M. Rothwell, FRCP, FMedSci From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK.

Correspondence to Sarah T. Pendlebury, MRCP, DPhil, Stroke Prevention Research Unit, Level 6 West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK. E-mail [email protected]

Background and Purpose— The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.

Methods— In a population-based study (Oxford Vascular Study) of transient ischemic attack and stroke, the MMSE and MoCA were administered to consecutive patients at 6-month or 5-year follow-up. Accepted cutoffs of MMSE <27 and MoCA <26 were taken to indicate cognitive impairment.

Results— Of 493 patients, 413 (84%) were testable. Untestable patients were older (75.5 versus 69.9 years, P<0.001) and often had dysphasia (24%) or dementia (15%). Although MMSE and MoCA scores were highly correlated (r2=0.80, P<0.001), MMSE scores were skewed toward higher values, whereas MoCA scores were normally distributed: median and interquartile range 28 (26 to 29) and 23 (20 to 26), respectively. Two hundred ninety-one of 413 (70%) patients had MoCA <26 of whom 162 had MMSE 27, whereas only 5 patients had MoCA 26 and MMSE <27 (P<0.0001). In patients with MMSE 27, MoCA <26 was associated with higher Rankin scores (P=0.0003) and deficits in delayed recall, abstraction, visuospatial/executive function, and sustained attention.

Conclusion— The MoCA picked up substantially more cognitive abnormalities after transient ischemic attack and stroke than the MMSE, demonstrating deficits in executive function, attention, and delayed recall.

Key Words: cognitive impairment • dementia • stroke • vascular cognitive impairment

The majority of patient with post-stroke Vascular Cognitive Impairment (VCI) have Vascular Cognitive Impairment No Dementia (VCIND). The Mini-Mental State Examination (MMSE) has been criticized as a poor screening test for VCIND due to insensitivity to visuospatial and executive function impairments. The Montreal Cognitive Assessment (MoCA) was designed to be more sensitive to such deficits and may therefore be a superior screening instrument for VCIND. Stable patients within 14days of their index stroke without significant physical disability, aphasia, dysarthria, active psychiatric illness or pre-existing dementia were eligible. Cognitive and neurological measures were administered after informed consent. 100 patients were recruited. Of the 57 patients with unimpaired MMSE scores, 18 (32%) patients had an impaired MoCA score. By comparison, only 2 out of the 41 (4.9%) patients with unimpaired MoCA scores had impaired MMSE scores. Moreover, MMSE domain subtest scores could not differentiate between groups of differing screening test results, whilst MoCA domain subtest scores (Visuospatial/Executive Function, Attention and Recall) could. The MoCA is more sensitive than the MMSE in screening for cognitive impairment after acute stroke. Longitudinal studies are required to establish the prognostic value of MoCA and MMSE evaluation in the acute post-stroke period for cognitive impairment as defined by the standard method of formal neuropsychological evaluation 3–6months after stroke.
  • Wong A, Xiong YY, Kwan PW, Chan AY, Lam WW, Wang K, et al. The validity, reliability and clinical utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in patients with cerebral small vessel disease. Dement Geriatr Cogn Disord. 2009;28:81–87