Multimodal CRISPR CAD

This repository contains all the code to reproduce results and create figures for the manuscript:

Wünnemann, F. et al. CRISPR perturbations at many coronary artery disease loci impair vascular endothelial cell functions. Preprint at https://doi.org/10.1101/2021.02.10.430527

Data availability

All raw sequencing data for the pooled CRISPR experiments, as well as the RNA-seq validation experiments is publicly available at NCBI Geo under the accession: GSE165925

Repository structure

• data - Contains all processed data and tables to produce figures and results.
• figures - Contains all final figures.
• plots - Contains subplots made to create figures.
• references - Contains reference tables (Gene-sets, genome annotations, etc.)
• scripts - Contains all scripts to process data and create figures