2024/12/23: If I get ALS, here's what I would do: I would start learning AI drug discovery from scratch, racing against time to eradicate ALS before I die. If the Grim Reaper wants my life, well, it depends on whether I agree or not !
“Study hard what interests you the most in the most undisciplined, irreverent and original manner possible.” — Richard P. Feynman
To accomplish something, a good plan only accounts for 5%; the remaining 95% depends on how you execute it and how you adjust on the fly according to the actual situation.
2024/12/23 - 12/25: study https://www.als.org/
2024/12/26 7:00 - 12/29 11:25: study https://en.wikipedia.org/wiki/ALS
2024/12/29 14:22 - 12/31 23:56: study the paper "RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice"
2025/1/1 0:42 - 1/2 23:50: Intrathecal administration of a novel siRNA modality extends survival and improves motor function in the SOD1G93A ALS mouse model
(why so slow)2025/1/2 23:50 - 1/10 12:00: study the news: SNUG01 is an innovative gene therapy drug developed by Shenji Changhua based on the endogenous neuroprotective molecule SG001 and using adeno-associated virus (AAV) as a vector.
2025/1/10 12:00 - : Khan Academy: High school biology
- 1/10 17:19 - 1/11 17:10: Unit 1: Ecology and natural systems
- Unit 2: From cells to organisms
- [ ]
2025/1/11 18:38 - : Khan Academy: High school chemistry
- 1/11 18:39 - 1/12 00:57: Unit 1: Atoms, isotopes, and ions
- Unit 2: Atomic models and periodicity
- [ ]
Khan Academy: High school biology, AP®︎/College Biology, High school chemistry, AP®︎/College Chemistry
https://ocw.mit.edu/courses/7-016-introductory-biology-fall-2018/
https://ocw.mit.edu/courses/7-013-introductory-biology-spring-2018/
https://ocw.mit.edu/courses/7-01sc-fundamentals-of-biology-fall-2011/
这个女孩应该是SOD1基因突变型ALS患者, 她的母亲说一个月打一针要十万元, 我猜这药物应该就是中美瑞康的李龙承博士团队开发的RAG-17 (https://www.askhelpu.com/?guanxian_118/), 我读的第一篇关于ALS的论文就是关于RAG-17的论文, 这药只能延缓病情发展, 根本无法根治。 都说AI发展迅速, 但是病人死得更快, 全世界每天都有多少病人死去? 大力推进AI制药, 要争分夺秒救人 !
If I get ALS, here's what I would do: I would start learning AI drug discovery from scratch, racing against time to eradicate ALS before I die. If the Grim Reaper wants my life, well, it depends on whether I agree or not !
2025/1/1 - 1/20 goals: I will continue to study based on the official website: first study the drug pipeline (clinical stage), then the drug pipeline (preclinical stage), followed by preclinical basic research, and then the monthly work updates. I aim to learn all the knowledge on the official website within 20 days (by January 20, 2025) and keep up with the work progress of Cai Lei's team.
打败死神, 获得永生, 征服宇宙。 有AI的帮助, 人类可以早日实现这些目标。反正我有太多的东西要学, 有太多的事情要做。当然人生短短几十年, 想怎么活, 是个人选择问题, 自己想清楚了, 临死的时候不后悔就够了
Running shirtless in the cold winter wind was incredibly refreshing. Kolmogorov, in his sixties or seventies, could still ski shirtless in the dead of winter, compete with young people, swim in cold water, boxing, and hike for dozens of kilometers. Kolmogorov also advised his students to swim several kilometers before studying mathematics. In terms of academic achievement, I can't compare to Kolmogorov, but in physical fitness, I'd really like to arm wrestle him. I remember an American statistician once said: 'I came to the Soviet Union to find out one thing - is Kolmogorov a person or an entire research institute?' Kolmogorov's productivity is astonishing, but from my analysis, he spent at least a quarter of his life on physical exercise. I firmly believe that physical exercise and high productivity do not conflict; on the contrary, physical exercise aids in the generation and development of brain neurons, thereby promoting more efficient learning and work.
The dearest possession of any person is life. It is given only once, and it must not be lived only to feel tortured by regrets for wasted years or to know the burning shame of a mean and petty past; so live that when dying you have a right to say: all my life, all my strength was given to the finest cause in the world – the fight for the liberation of humankind.
Either die amid endless internal competition or perish while venturing into the unknown. Two ways to die—choose one.