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# mpld
A database of Mitochondrial Proteins Linked with Diseases
# mitoPADdb
A database of Mitochondrial Proteins Associated with Diseases

The mitoPADdb is a manually curated database that provides comprehensive information on *813 mitochondrial
protein-encoding (MPE) genes* associated with *1793 disease terms*. It contains information on mutations
and expressional variations of MPE genes at both the mRNA and protein levels. The database classifies the
diseases linked with mitochondrial proteins into *14 broad categories*.

## About mitoPADdb
mitoPADdb is available at: [http://bicresources.jcbose.ac.in/ssaha4/mitopaddb](http://bicresources.jcbose.ac.in/ssaha4/mitopaddb).

The data statistics of mitoPADdb is available in the [Statistics](http://bicresources.jcbose.ac.in/ssaha4/mitopaddb/statistics.html)
page. Please refer to the [Help](http://bicresources.jcbose.ac.in/ssaha4/mitopaddb/help.html) page for
understanding the data and usage of mitoPADdb. It allows users to access the data using two ways -

1. **Search option**: The search option allows the users top search the database with Gene symbol, UniProt
accession, or both.

The search option provides information about *18356 mutations*, *1286 expressional variations* (mRNA
and protein levels) with experimental samples and techniques, and associated diseases with source
identifiers.

3. **Browse options**: The browse options allow users to access these data along with disease-gene-pathway
links and differential genes’ expression heatmap across *317 disease studies*, in following ways.

* Gene symbol
* Pathway name
* Disease category name
* Disease category-wise MPE gene expression heatmap
* Disease category-pairwise comparison of MPE gene expression heatmap

## Team
* **Jagannath Das** *([[email protected]](mailto:[email protected]))*<br/>
Senior Research Fellow,<br/>
Department of Biological Sciences,<br/>
Bose Institute, Kolkata, India.<br/>
* **Sudipto Bhattacharjee** *([[email protected]](mailto:[email protected]))*<br/>
Ph.D. Scholar,<br/>
Department of Computer Science and Engineering,<br/>
University of Calcutta, Kolkata, India.<br/>
* **Dr. Sudipto Saha** *([[email protected]](mailto:[email protected]))*<br/>
Associate Professor,<br/>
Department of Biological Sciences,<br/>
Bose Institute, Kolkata, India.

*Please contact Dr. Sudipto Saha regarding any further queries.*

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