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Release v1.0.0

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@franla23 franla23 released this 22 Sep 11:24
· 1724 commits to master since this release

Major changes

  • Added a model for epitopes
  • Optionally, output a table with all annotated epitopes obtained from a set of input neoantigens (option --with-all-neoepitopes)
  • Additional command line tool neofox-epitope that accepts epitopes as input. The epitopes may be associated with a particular HLA allele or alternatively paired with each of the HLA alleles defined in a given patient
  • MHC-II weak binder threshold changed from 10 to 5
  • Output JSON file with reference resources metadata with the aim of documenting the reference data versions

Minor changes

  • Neoantigen model is simplified by removing the Mutation entity
  • Annotations are renamed with the aim of making them more self explanatory
  • Always output tabular and JSON data as opposed to choosing output format
  • Input parameters --candidate-file and --json-file are simplified into --input-file. The format of the input is inferred from the file - extension, being valid extensions *.txt and *.tsv for tabular format; and *.json for JSON format.
  • Recognition potential is now also annotated when mutation not in anchor positions
  • Dask cluster is now closed in a cleaner way
  • Some of the binaries are now optionally read from the PATH
  • All temporary files from MHC prediction are removed now, this caused troubles for large datasets
  • Now all relevant peptides of length 8-14 are considerd while MHC-I prediction (previously: 8-11)