Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Add protein-translation exercise #61

Merged
merged 6 commits into from
Jul 4, 2024
Merged
Show file tree
Hide file tree
Changes from all commits
Commits
File filter

Filter by extension

Filter by extension

Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
7 changes: 7 additions & 0 deletions concepts/dictionaries/.meta/config.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,7 @@
{
"blurb": "<todo>",
"authors": [
"misicnenad"
],
"contributors": []
}
1 change: 1 addition & 0 deletions concepts/dictionaries/about.md
Original file line number Diff line number Diff line change
@@ -0,0 +1 @@
# Dictionaries
1 change: 1 addition & 0 deletions concepts/dictionaries/introduction.md
Original file line number Diff line number Diff line change
@@ -0,0 +1 @@
# Introduction
1 change: 1 addition & 0 deletions concepts/dictionaries/links.json
Original file line number Diff line number Diff line change
@@ -0,0 +1 @@
[]
24 changes: 23 additions & 1 deletion config.json
Original file line number Diff line number Diff line change
Expand Up @@ -226,9 +226,26 @@
"slug": "sublist",
"name": "Sublist",
"uuid": "e62b1bb4-fb37-4dfe-ad81-e0fa5c494ba3",
"practices": ["arrays", "enums", "generics"],
"practices": [
"arrays",
"enums",
"generics"
],
"prerequisites": [],
"difficulty": 3
},
{
"slug": "protein-translation",
"name": "Protein Translation",
"uuid": "d42e7a29-64b9-478b-8b2a-44fd002391fa",
"practices": [
"dictionaries",
"strings",
"felts",
"type-conversion"
],
"prerequisites": [],
"difficulty": 8
}
],
"foregone": [
Expand Down Expand Up @@ -257,6 +274,11 @@
"slug": "generics",
"name": "Generic Types"
},
{
"uuid": "7e7b772a-2b3e-47d7-96ef-807a4d5b3545",
"slug": "dictionaries",
"name": "Dictionaries"
},
{
"uuid": "de254443-42ee-4787-bc1e-3d0d2039c4f5",
"slug": "booleans",
Expand Down
45 changes: 45 additions & 0 deletions exercises/practice/protein-translation/.docs/instructions.md
Original file line number Diff line number Diff line change
@@ -0,0 +1,45 @@
# Instructions

Translate RNA sequences into proteins.

RNA can be broken into three nucleotide sequences called codons, and then translated to a polypeptide like so:

RNA: `"AUGUUUUCU"` => translates to

Codons: `"AUG", "UUU", "UCU"`
=> which become a polypeptide with the following sequence =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

There are 64 codons which in turn correspond to 20 amino acids; however, all of the codon sequences and resulting amino acids are not important in this exercise.
If it works for one codon, the program should work for all of them.
However, feel free to expand the list in the test suite to include them all.

There are also three terminating codons (also known as 'STOP' codons); if any of these codons are encountered (by the ribosome), all translation ends and the protein is terminated.

All subsequent codons after are ignored, like this:

RNA: `"AUGUUUUCUUAAAUG"` =>

Codons: `"AUG", "UUU", "UCU", "UAA", "AUG"` =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

Note the stop codon `"UAA"` terminates the translation and the final methionine is not translated into the protein sequence.

Below are the codons and resulting Amino Acids needed for the exercise.

| Codon | Protein |
| :----------------- | :------------ |
| AUG | Methionine |
| UUU, UUC | Phenylalanine |
| UUA, UUG | Leucine |
| UCU, UCC, UCA, UCG | Serine |
| UAU, UAC | Tyrosine |
| UGU, UGC | Cysteine |
| UGG | Tryptophan |
| UAA, UAG, UGA | STOP |

Learn more about [protein translation on Wikipedia][protein-translation].

[protein-translation]: https://en.wikipedia.org/wiki/Translation_(biology)
19 changes: 19 additions & 0 deletions exercises/practice/protein-translation/.meta/config.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,19 @@
{
"authors": [
"misicnenad"
],
"files": {
"solution": [
"src/lib.cairo",
"Scarb.toml"
],
"test": [
"src/tests.cairo"
],
"example": [
".meta/example.cairo"
]
},
"blurb": "Translate RNA sequences into proteins.",
"source": "Tyler Long"
}
109 changes: 109 additions & 0 deletions exercises/practice/protein-translation/.meta/example.cairo
Original file line number Diff line number Diff line change
@@ -0,0 +1,109 @@
use core::dict::Felt252DictEntryTrait;
use core::num::traits::zero::Zero;

#[derive(Destruct)]
struct CodonsInfo {
actual_codons: Felt252Dict<Nullable<ByteArray>>,
}

enum TranslateResult {
Invalid,
Stopped,
Ok
}

fn parse(pairs: Array<(felt252, ByteArray)>) -> CodonsInfo {
let mut pairs = pairs;
let mut actual_codons: Felt252Dict<Nullable<ByteArray>> = Default::default();
while let Option::Some((codon, name)) = pairs
.pop_front() {
actual_codons.insert(codon, NullableTrait::new(name));
};
CodonsInfo { actual_codons, }
}

#[generate_trait]
impl CodonsInfoImpl of CodonsInfoTrait {
fn name_for(ref self: CodonsInfo, codon: felt252) -> ByteArray {
let (entry, _name) = self.actual_codons.entry(codon);
let name = _name.deref_or("");
let res = name.clone();
self.actual_codons = entry.finalize(NullableTrait::new(name));
res
}

fn of_rna(ref self: CodonsInfo, strand: ByteArray) -> Option<Array<ByteArray>> {
let mut result: Array<ByteArray> = array![];

let mut codon_index = 0;
let translate_result = loop {
if codon_index == strand.len() {
break TranslateResult::Ok;
}

if let Option::Some(codon) = strand.codon_chunk(codon_index) {
let name = self.name_for(codon);
if name == "" {
break TranslateResult::Invalid;
} else if name == "stop codon" {
break TranslateResult::Stopped;
}

result.append(name);
codon_index += 3;
} else {
break TranslateResult::Invalid;
}
};

match translate_result {
TranslateResult::Invalid => Option::None,
_ => Option::Some(result)
}
}
}

const TWO_POW_8: u32 = 0x100;
const TWO_POW_16: u32 = 0x10000;

#[generate_trait]
impl CodonChunk of CodonChunkTrait {
/// Given a ByteArray, extracts a codon from a given index `from`.
/// Needs to extract 3 ByteArray characters and convert them to the appropriate
/// felt252 value. It does this by taking the characters' byte value and moving
/// their bits to the left depending on their position in the codon.
///
/// Example:
/// 1. Method call: "AUG".codon_chunk(0)
/// 2. Chars and their byte (hex) values:
/// - "A" = 0x41
/// - "U" = 0x55
/// - "G" = 0x47
/// 3. "A" is the leftmost character, so we "move" it 2 bytes to the left by
/// multiplying it by 2^16 (hex value: 0x10000)
/// 4. "U" is the middle character, so we "move" it 1 byte to the left by
/// multiplying it by 2^8 (hex value: 0x100)
/// 5. "G" is the rightmost character, so we leave it in place
/// 6. Codon = "A" * 2^16 + "U" * 2^8 + "G"
/// = 0x41 * 0x10000 + 0x55 * 0x100 * 0x47
/// = 0x415547
/// 7. (41)(55)(47) are hex values for (A)(U)(G)
///
/// Returns:
/// - Option::Some(codon) -> if the extraction was successful
/// - Option::None -> if the ByteArray was too short from the given index
fn codon_chunk(self: @ByteArray, from: usize) -> Option<felt252> {
if let Option::Some(char) = self.at(from + 2) {
let codon = char.into()
+ self[from
+ 1].into() * TWO_POW_8
+ self[from].into() * TWO_POW_16;
Option::Some(codon.into())
} else {
Option::None
}
}
}

#[cfg(test)]
mod tests;
105 changes: 105 additions & 0 deletions exercises/practice/protein-translation/.meta/tests.toml
Original file line number Diff line number Diff line change
@@ -0,0 +1,105 @@
# This is an auto-generated file.
#
# Regenerating this file via `configlet sync` will:
# - Recreate every `description` key/value pair
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion)
# - Preserve any other key/value pair
#
# As user-added comments (using the # character) will be removed when this file
# is regenerated, comments can be added via a `comment` key.

[2c44f7bf-ba20-43f7-a3bf-f2219c0c3f98]
description = "Empty RNA sequence results in no proteins"

[96d3d44f-34a2-4db4-84cd-fff523e069be]
description = "Methionine RNA sequence"

[1b4c56d8-d69f-44eb-be0e-7b17546143d9]
description = "Phenylalanine RNA sequence 1"

[81b53646-bd57-4732-b2cb-6b1880e36d11]
description = "Phenylalanine RNA sequence 2"

[42f69d4f-19d2-4d2c-a8b0-f0ae9ee1b6b4]
description = "Leucine RNA sequence 1"

[ac5edadd-08ed-40a3-b2b9-d82bb50424c4]
description = "Leucine RNA sequence 2"

[8bc36e22-f984-44c3-9f6b-ee5d4e73f120]
description = "Serine RNA sequence 1"

[5c3fa5da-4268-44e5-9f4b-f016ccf90131]
description = "Serine RNA sequence 2"

[00579891-b594-42b4-96dc-7ff8bf519606]
description = "Serine RNA sequence 3"

[08c61c3b-fa34-4950-8c4a-133945570ef6]
description = "Serine RNA sequence 4"

[54e1e7d8-63c0-456d-91d2-062c72f8eef5]
description = "Tyrosine RNA sequence 1"

[47bcfba2-9d72-46ad-bbce-22f7666b7eb1]
description = "Tyrosine RNA sequence 2"

[3a691829-fe72-43a7-8c8e-1bd083163f72]
description = "Cysteine RNA sequence 1"

[1b6f8a26-ca2f-43b8-8262-3ee446021767]
description = "Cysteine RNA sequence 2"

[1e91c1eb-02c0-48a0-9e35-168ad0cb5f39]
description = "Tryptophan RNA sequence"

[e547af0b-aeab-49c7-9f13-801773a73557]
description = "STOP codon RNA sequence 1"

[67640947-ff02-4f23-a2ef-816f8a2ba72e]
description = "STOP codon RNA sequence 2"

[9c2ad527-ebc9-4ace-808b-2b6447cb54cb]
description = "STOP codon RNA sequence 3"

[f4d9d8ee-00a8-47bf-a1e3-1641d4428e54]
description = "Sequence of two protein codons translates into proteins"

[dd22eef3-b4f1-4ad6-bb0b-27093c090a9d]
description = "Sequence of two different protein codons translates into proteins"

[d0f295df-fb70-425c-946c-ec2ec185388e]
description = "Translate RNA strand into correct protein list"

[e30e8505-97ec-4e5f-a73e-5726a1faa1f4]
description = "Translation stops if STOP codon at beginning of sequence"

[5358a20b-6f4c-4893-bce4-f929001710f3]
description = "Translation stops if STOP codon at end of two-codon sequence"

[ba16703a-1a55-482f-bb07-b21eef5093a3]
description = "Translation stops if STOP codon at end of three-codon sequence"

[4089bb5a-d5b4-4e71-b79e-b8d1f14a2911]
description = "Translation stops if STOP codon in middle of three-codon sequence"

[2c2a2a60-401f-4a80-b977-e0715b23b93d]
description = "Translation stops if STOP codon in middle of six-codon sequence"

[f6f92714-769f-4187-9524-e353e8a41a80]
description = "Sequence of two non-STOP codons does not translate to a STOP codon"

[1e75ea2a-f907-4994-ae5c-118632a1cb0f]
description = "Non-existing codon can't translate"
include = false

[9eac93f3-627a-4c90-8653-6d0a0595bc6f]
description = "Unknown amino acids, not part of a codon, can't translate"
reimplements = "1e75ea2a-f907-4994-ae5c-118632a1cb0f"

[9d73899f-e68e-4291-b1e2-7bf87c00f024]
description = "Incomplete RNA sequence can't translate"

[43945cf7-9968-402d-ab9f-b8a28750b050]
description = "Incomplete RNA sequence can translate if valid until a STOP codon"
4 changes: 4 additions & 0 deletions exercises/practice/protein-translation/Scarb.toml
Original file line number Diff line number Diff line change
@@ -0,0 +1,4 @@
[package]
name = "protein_translation"
version = "0.1.0"
edition = "2023_11"
Loading
Loading