Supplementary material for paper Estimation of clinical utility in estimated clinical trials

This repository is a supplement to our paper and contains all the R code for simulations and contains the estimators used in the real data example. In variance_estimation are two version of the clinical utility used to estimate the clinical utility and its asymptotic variances. The estimators in the script variance_estimate.R estimate the clinical utility of two DTRs where as the script variance_estimate_SOC uses only one DTR compares it to the standard of care (SOC).

Description

The R scripts in this repository are used to perform simulations and implement the estimators described in the paper.

Prerequisites

• R version 4.0 or higher
• Required R packages:
  • ggplot2
  • nnet
  • xtable