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added logo to README
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jr-leary7 committed Sep 29, 2024
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3 changes: 1 addition & 2 deletions README.Rmd
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---
title: "<img src='man/figures/scLANE_logo.png' align='right' height='20%' width='20%'/>"
output:
github_document:
toc: true
Expand All @@ -22,8 +23,6 @@ knitr::opts_chunk$set(warning = FALSE,
fig.height = 4)
```

# `scLANE`

<!-- badges: start -->
[![R-CMD-check](https://github.com/jr-leary7/scLANE/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/jr-leary7/scLANE/actions/workflows/R-CMD-check.yaml)
[![Bioc-check](https://github.com/jr-leary7/scLANE/actions/workflows/bioc-check.yaml/badge.svg)](https://github.com/jr-leary7/scLANE/actions/workflows/bioc-check.yaml)
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32 changes: 15 additions & 17 deletions README.md
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<img src='man/figures/scLANE_logo.png' align='right' height='20%' width='20%'/>
================

- [`scLANE`](#sclane)
- [Installation](#installation)
- [Model structure](#model-structure)
- [Installation](#installation)
- [Model structure](#model-structure)
- [Usage](#usage)
- [Libraries](#libraries)
- [Input data](#input-data)
Expand All @@ -13,9 +14,6 @@
- [References](#references)

<!-- README.md is generated from README.Rmd. Please edit that file -->

# `scLANE`

<!-- badges: start -->

[![R-CMD-check](https://github.com/jr-leary7/scLANE/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/jr-leary7/scLANE/actions/workflows/R-CMD-check.yaml)
Expand Down Expand Up @@ -173,7 +171,7 @@ scLANE_models_glm <- testDynamic(sim_data,
#> Registered S3 method overwritten by 'bit':
#> method from
#> print.ri gamlss
#> scLANE testing in GLM mode completed for 100 genes across 1 lineage in 16.068 secs
#> scLANE testing in GLM mode completed for 100 genes across 1 lineage in 26.604 secs
```

After the function finishes running, we use `getResultsDE()` to generate
Expand All @@ -194,10 +192,10 @@ select(scLANE_res_glm, Gene, Lineage, Test_Stat, P_Val, P_Val_Adj, Gene_Dynamic_
| Gene | Lineage | LRT stat. | P-value | Adj. p-value | Predicted dynamic status |
|:-------|:--------|----------:|--------:|-------------:|-------------------------:|
| MFSD2B | A | 217.016 | 0.000 | 0.000 | 1 |
| LGR4 | A | 6.685 | 0.035 | 1.000 | 0 |
| UAP1L1 | A | 9.882 | 0.007 | 0.365 | 0 |
| NLGN4Y | A | 6.471 | 0.039 | 1.000 | 0 |
| UAP1L1 | A | 9.882 | 0.007 | 0.357 | 0 |
| TMCO3 | A | 167.764 | 0.000 | 0.000 | 1 |
| MRTO4 | A | 4.771 | 0.092 | 1.000 | 0 |
| ZBTB43 | A | 4.538 | 0.103 | 1.000 | 0 |

### GEE mode

Expand All @@ -220,7 +218,7 @@ scLANE_models_gee <- testDynamic(sim_data,
cor.structure = "ar1",
n.cores = 6L,
verbose = FALSE)
#> scLANE testing in GEE mode completed for 100 genes across 1 lineage in 46.169 secs
#> scLANE testing in GEE mode completed for 100 genes across 1 lineage in 1.499 mins
```

We again generate the table of DE test results. The variance of the
Expand All @@ -239,10 +237,10 @@ select(scLANE_res_gee, Gene, Lineage, Test_Stat, P_Val, P_Val_Adj, Gene_Dynamic_
| Gene | Lineage | Wald stat. | P-value | Adj. p-value | Predicted dynamic status |
|:------|:--------|-----------:|--------:|-------------:|-------------------------:|
| BAD | A | 159682.044 | 0 | 0 | 1 |
| RPL29 | A | 32.647 | 0 | 0 | 1 |
| TBCC | A | 31.307 | 0 | 0 | 1 |
| HOXC8 | A | NA | NA | NA | 0 |
| DDX41 | A | 4216.586 | 0 | 0 | 1 |
| PFDN2 | A | 2362.431 | 0 | 0 | 1 |
| NPC2 | A | 3698.406 | 0 | 0 | 1 |
| MPG | A | 2270.035 | 0 | 0 | 1 |

### GLMM mode

Expand All @@ -266,7 +264,7 @@ scLANE_models_glmm <- testDynamic(sim_data,
id.vec = sim_data$subject,
n.cores = 6L,
verbose = FALSE)
#> scLANE testing in GLMM mode completed for 100 genes across 1 lineage in 2.248 mins
#> scLANE testing in GLMM mode completed for 100 genes across 1 lineage in 3.386 mins
```

**Note:** The GLMM mode is still under development, as we are working on
Expand All @@ -289,8 +287,8 @@ select(scLANE_res_glmm, Gene, Lineage, Test_Stat, P_Val, P_Val_Adj, Gene_Dynamic
| Gene | Lineage | LRT stat. | P-value | Adj. p-value | Predicted dynamic status |
|:--------|:--------|----------:|--------:|-------------:|-------------------------:|
| VDAC1 | A | 151.417 | 0 | 0 | 1 |
| KLHDC10 | A | 122.491 | 0 | 0 | 1 |
| ZNF575 | A | NA | NA | NA | 0 |
| KLHDC10 | A | 121.011 | 0 | 0 | 1 |
| NOP14 | A | NA | NA | NA | 0 |
| BCAT1 | A | NA | NA | NA | 0 |
| TSPAN1 | A | 78.597 | 0 | 0 | 1 |

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