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Modified Base Estimation Upgrade
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@marcus1487 marcus1487 released this 15 Dec 01:08
· 74 commits to master since this release
1.1
b912c4a

The primary update in this version of Tombo is a major shift in the alternative base model estimation method. This method still uses the same practical sample type, but produces a much better model. On an E. coli test dataset AUC is improved from 0.77 to 0.89. This model is now included as the default 5-methyl cytosine model in Tombo.

Additional changes in this version:

  • Full package documentation
  • Better signal normalization
  • Filter reads to even read depth
  • Minor bug fixes
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