Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Added antismash params: pfam2go, rre, tfbs #403

Merged
merged 2 commits into from
Jul 19, 2024
Merged
Show file tree
Hide file tree
Changes from all commits
Commits
File filter

Filter by extension

Filter by extension

Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
1 change: 1 addition & 0 deletions CHANGELOG.md
Original file line number Diff line number Diff line change
Expand Up @@ -17,6 +17,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
- [#381](https://github.com/nf-core/funcscan/pull/381) Added support for supplying pre-annotated sequences to the pipeline. (by @jfy133, @jasmezz)
- [#382](https://github.com/nf-core/funcscan/pull/382) Optimised BGC screening run time and prevent crashes due to too-short contigs by adding contig length filtering for BGC workflow only. (by @jfy133, @darcy220606)
- [#366](https://github.com/nf-core/funcscan/pull/366) Added nf-test on pipeline level. (by @jfy133, @Darcy220606, @jasmezz)
- [#403](https://github.com/nf-core/funcscan/pull/403) Added antiSMASH parameters `--pfam2go`, `--rre`, and `--tfbs`. (reported by @Darcy220606, added by @jasmezz)

### `Fixed`

Expand Down
3 changes: 3 additions & 0 deletions conf/modules.config
Original file line number Diff line number Diff line change
Expand Up @@ -412,6 +412,9 @@ process {
params.bgc_antismash_smcogtrees ? '--smcog-trees' : '',
params.bgc_antismash_ccmibig ? '--cc-mibig' : '',
params.bgc_antismash_cbsubclusters ? '--cb-subclusters' : '',
params.bgc_antismash_pfam2go ? '--pfam2go' : '',
params.bgc_antismash_rre ? '--rre' : '',
params.bgc_antismash_tfbs ? '--tfbs' : '',
"--allow-long-headers",
"--minlength ${params.bgc_antismash_contigminlength}",
"--hmmdetection-strictness ${params.bgc_antismash_hmmdetectionstrictness}",
Expand Down
3 changes: 3 additions & 0 deletions nextflow.config
Original file line number Diff line number Diff line change
Expand Up @@ -204,7 +204,10 @@ params {
bgc_antismash_ccmibig = false
bgc_antismash_contigminlength = 3000
bgc_antismash_hmmdetectionstrictness = 'relaxed'
bgc_antismash_pfam2go = false
bgc_antismash_rre = false
bgc_antismash_taxon = 'bacteria'
bgc_antismash_tfbs = false

bgc_skip_deepbgc = false
bgc_deepbgc_db = null
Expand Down
21 changes: 21 additions & 0 deletions nextflow_schema.json
Original file line number Diff line number Diff line change
Expand Up @@ -1176,13 +1176,34 @@
"fa_icon": "fas fa-search",
"enum": ["relaxed", "strict", "loose"]
},
"bgc_antismash_pfam2go": {
"type": "boolean",
"default": "false",
"description": "Run Pfam to Gene Ontology mapping module.",
"help_text": "This maps the proteins to Pfam database to annotate BGC modules with functional information based on the protein families they contain. For more information see the antiSMASH [documentation](https://docs.antismash.secondarymetabolites.org/).\n\n> Modifies tool parameter(s):\n> - antiSMASH: `--pfam2go`",
"fa_icon": "fas fa-search"
},
"bgc_antismash_rre": {
"type": "boolean",
"default": "false",
"description": "Run RREFinder precision mode on all RiPP gene clusters.",
"help_text": "This enables the prediction of regulatory elements on the BGC that help in the control of protein expression. For more information see the antiSMASH [documentation](https://docs.antismash.secondarymetabolites.org/).\n\n> Modifies tool parameter(s):\n> - antiSMASH: `--rre`",
"fa_icon": "fas fa-search"
},
"bgc_antismash_taxon": {
"type": "string",
"default": "bacteria",
"description": "Specify which taxonomic classification of input sequence to use.",
"help_text": "This specifies which set of secondary metabolites to screen for, based on the taxon type the secondary metabolites are from.\n\nThis will run different pipelines depending on whether the input sequences are from bacteria or fungi.\n\nFor more information see the antiSMASH [documentation](https://docs.antismash.secondarymetabolites.org/).\n\n> Modifies tool parameter(s):\n> - antiSMASH: `--taxon`",
"fa_icon": "fas fa-bacteria",
"enum": ["bacteria", "fungi"]
},
"bgc_antismash_tfbs": {
"type": "boolean",
"default": "false",
"description": "Run TFBS finder on all gene clusters.",
"help_text": "This enables the prediction of transcription factor binding sites which control the gene expression. For more information see the antiSMASH [documentation](https://docs.antismash.secondarymetabolites.org/).\n\n> Modifies tool parameter(s):\n> - antiSMASH: `--tfbs`",
"fa_icon": "fas fa-search"
}
},
"fa_icon": "fa fa-sliders"
Expand Down
Loading