This package includes examplar of mr.ios as well as simulations.
Here we tested the associations of the following phenotypes using IWV Radial MR, adding IOS as an extra weight;
- BMI - CHD
- SBP - CHD
- EDU - BMI
- Sleep - Schizophrenia
- Urate - CHD
- Urate - eGFR
- CRP - CHD
This simulation is designed to see whether decreased level of heterogeneity in MR analysis is because IOS score accounts for pleiotropic effect in MR model or just by chance.