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User defined rules #21

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dansuissa wants to merge 2 commits into Adibvafa:main from dansuissa:user-defined-rules

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dansuissa commented Feb 13, 2025

Fixes #7: Add user-defined rules for DNA sequence complexity

Added new CodonComplexity module with configurable rules
Implemented Twist's synthesis requirements:
- Repeat sequence detection (≥20bp or Tm ≥60°C)
- GC content checks (25-65% globally, max 52% deviation)
- Homopolymer identification
- HIS tag pattern validation
Added sequence regeneration capability when complexity checks fail
Updated prediction function to support complexity checking

Note:
Would you like me to add any additional test cases or documentation?

dansuissa added 2 commits

February 13, 2025 10:34


          Create CodonComplexity.py

763c8d9

Add CodonComplexity module for sequence complexity checks


          Update CodonPrediction.py

818a004

Update CodonPrediction with complexity checking functionality and updated docstrings

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