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allyhawkins committed Jan 3, 2025
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The goal of this module is to create a reference that can be used to define an ontology aware consensus cell type label for all cells across all ScPCA samples.
This module performs a series of steps to accomplish that goal:

1. The cell type annotations present in the `PanglaoDB` reference file were assigned to an ontology term identifier, when possible.
1. The cell type annotations present in the `PanglaoDB` reference file were assigned to an ontology term identifier, when possible.
See [`references/README.md`](./references/README.md) for a full description on how we completed assignments.
2. We looked at all possible combinations of cell type labels between the `PanglaoDB` reference (used with `CellAssign`) and the `BlueprintEncodeData` reference (used with `SingleR`).
We then explored using a set of rules used to define consensus cell types in [`exploratory-notebooks/01-reference-exploration.Rmd`](./exploratory-notebooks/01-reference-exploration.Rmd).
3. We created a [reference table](./references/consensus-cell-type-reference.tsv) containing all combinations for which we were able to identify a consensus cell type label.
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