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pb-StarPhase v0.10.1

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@holtjma holtjma released this 16 May 16:55
· 31 commits to main since this release

Changes

  • Updated the crate for CYP2D6 generation, improving alignment offset seeding and reducing over-splitting for shorter reads (e.g., targeted sequencing)
  • Added a secondary penalty for using a non-unique chain pair during the CYP2D6 chaining step. This tends to reduce errors caused by ambiguous chains in WGS datasets.

Fixed

  • Fixed an issue with CYP2D6 where an "UNKNOWN" cluster could erroneously generate an extra allele when two defined alleles came from the same HPC-cluster
  • Fixed an issue with CYP2D6 where alleles excluding from normalization could form their own unpenalized haplotype (e.g., a *68 allele by itself)
  • Fixed a panic caused by typing an empty CYP2D6 sequence
  • Fixed a panic caused by no usable reads in the CYP2D6 search region