A comprehensive characterization of the transcriptional regulatory network of Streptomyces albidoflavus J1074. iModulons are independently-modulated groups of genes that are computed through Independent Component Analysis (ICA) of a gene expression dataset (see here for more details).
This repository presents a computational workflow to compute and characterize all iModulons for S. albidoflavus:
- Process all available RNA-seq data.
- Inspect data to identify high-quality datasets.
- Compute iModulons.
- Characterize iModulons using PyModulon.
A pre-print is currently being prepared highlighting the results of this study.