TISCH

Tumor Immune Single-cell Hub (TISCH) is a scRNA-seq database, which focuses on tumor microenvironment (TME). TISCH provides detailed cell-type annotation for all curated datasets, enabling the exploration of TME across different cancer types.

Release 1 - July 11th, 2020

Data statistics

• 28 cancer types.
• 79 datasets: 15 datasets with ICB treatment (10 for human and 5 for mouse), 61 non-ICB datasets and 3 PBMC datasets.
• 2,045,746 cells: 378,392 malignant cells and 1,667,354 non-malignant cells.

Features

• Gene module: Search a gene across species and cancer types.
• Single-dataset exploration: 1. Overview of dataset; 2. Gene expression visualization at both single-cell level (UMAP plot) and cluster level (violin plot); 3. Functional enrichment analysis (GSEA); 4. Download files (cluster-level expression matrices, DE gene table and meta information).
• Multiple-dataset comparison: Compare expression of genes across multiple datasets.